Search Results - "Suratt, Benjamin T."

Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice by Ather, Jennifer L, Ckless, Karina, Martin, Rebecca, Foley, Kathryn L, Suratt, Benjamin T, Boyson, Jonathan E, Fitzgerald, Katherine A, Flavell, Richard A, Eisenbarth, Stephanie C, Poynter, Matthew E

“…IL-1β is a cytokine critical to several inflammatory diseases in which pathogenic Th17 responses are implicated. Activation of the NLRP3 inflammasome by…”
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Isolation and Characterization of Mouse Neutrophils by Ubags, Niki D J, Suratt, Benjamin T

“…Isolation of murine neutrophils from several anatomical compartments allows for functional characterization and analysis of these cells. Here we describe the…”
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Immunomodulatory and clinical effects of receptor-interacting protein kinase 1 (RIPK1) inhibitor eclitasertib (SAR443122) in patients with severe COVID-19: a phase 1b, randomized, double-blinded, placebo-controlled study by Clot, Pierre-Francois, Farenc, Christine, Suratt, Benjamin T, Krahnke, Tillmann, Tardat, Agnes, Florian, Peter, Pomponio, Robert, Patel, Naimish, Wiekowski, Maria, Lin, Yong, Terrier, Benjamin, Staudinger, Heribert

“…Targeting receptor-interacting serine/threonine protein kinase 1 could mitigate the devastating sequelae of the hyperinflammatory state observed in severe…”
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Future Research Directions in Pneumonia. NHLBI Working Group Report by Dela Cruz, Charles S, Wunderink, Richard G, Christiani, David C, Cormier, Stephania A, Crothers, Kristina, Doerschuk, Claire M, Evans, Scott E, Goldstein, Daniel R, Khatri, Purvesh, Kobzik, Lester, Kolls, Jay K, Levy, Bruce D, Metersky, Mark L, Niederman, Michael S, Nusrat, Roomi, Orihuela, Carlos J, Peyrani, Paula, Prince, Alice S, Ramírez, Julio A, Ridge, Karen M, Sethi, Sanjay, Suratt, Benjamin T, Sznajder, Jacob I, Tsalik, Ephraim L, Walkey, Allan J, Yende, Sachin, Aggarwal, Neil R, Caler, Elisabet V, Mizgerd, Joseph P

“…Pneumonia is a complex pulmonary disease in need of new clinical approaches. Although triggered by a pathogen, pneumonia often results from dysregulations of…”
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Myeloid derived hypoxia inducible factor 1-alpha is required for protection against pulmonary Aspergillus fumigatus infection by Shepardson, Kelly M, Jhingran, Anupam, Caffrey, Alayna, Obar, Joshua J, Suratt, Benjamin T, Berwin, Brent L, Hohl, Tobias M, Cramer, Robert A

“…Hypoxia inducible factor 1α (HIF1α) is the mammalian transcriptional factor that controls metabolism, survival, and innate immunity in response to inflammation…”
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Extreme Obesity and Outcomes in Critically Ill Patients by Martino, Jenny L., MD, MSPH, Stapleton, Renee D., MD, PhD, FCCP, Wang, Miao, MSc, Day, Andrew G., MSc, Cahill, Naomi E., RD, MSc, Dixon, Anne E., MD, FCCP, Suratt, Benjamin T., MD, FCCP, Heyland, Daren K., MD

“…Background Recent literature suggests that obese critically ill patients do not have worse outcomes than patients who are normal weight. However, outcomes in…”
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Retraction Note: Obesity-induced adipokine imbalance impairs mouse pulmonary vascular endothelial function and primes the lung for injury by Shah, Dilip, Romero, Freddy, Duong, Michelle, Wang, Nadan, Paudyal, Bishnuhari, Suratt, Benjamin T., Kallen, Caleb B., Sun, Jianxin, Zhu, Ying, Walsh, Kenneth, Summer, Ross

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Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics by Chamberlain, Nicolas, Korwin-Mihavics, Bethany R, Nakada, Emily M, Bruno, Sierra R, Heppner, David E, Chapman, David G, Hoffman, Sidra M, van der Vliet, Albert, Suratt, Benjamin T, Dienz, Oliver, Alcorn, John F, Anathy, Vikas

“…Protein disulfide isomerases (PDI) are a family of redox chaperones that catalyze formation or isomerization of disulfide bonds in proteins. Previous studies…”
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Obesity and Nutrition in Acute Respiratory Distress Syndrome by Stapleton, Renee D., MD, PhD, Suratt, Benjamin T., MD

“…This article discusses obesity, its contribution to clinical outcomes, and the current literature on nutrition. More than one third of Americans are obese…”
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In ARDS, Heterogeneity = Opportunity by Suratt, Benjamin T., MD, FCCP, Parsons, Polly E., MD, FCCP

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Weight Loss Decreases Inherent and Allergic Methacholine Hyperresponsiveness in Mouse Models of Diet-Induced Obese Asthma by Ather, Jennifer L, Chung, Michael, Hoyt, Laura R, Randall, Matthew J, Georgsdottir, Anna, Daphtary, Nirav A, Aliyeva, Minara I, Suratt, Benjamin T, Bates, Jason H T, Irvin, Charles G, Russell, Sheila R, Forgione, Patrick M, Dixon, Anne E, Poynter, Matthew E

“…Obese asthma presents with inherent hyperresponsiveness to methacholine or augmented allergen-driven allergic asthma, with an even greater magnitude of…”
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Crosstalk between CXCR4/Stromal Derived Factor-1 and VLA-4/VCAM-1 Pathways Regulates Neutrophil Retention in the Bone Marrow by Petty, Joseph M, Lenox, Christopher C, Weiss, Daniel J, Poynter, Matthew E, Suratt, Benjamin T

“…Neutrophil retention in and release from the bone marrow is a critical process that remains incompletely understood. Previous work has implicated the…”
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Extremes of Interferon-Stimulated Gene Expression Associate with Worse Outcomes in the Acute Respiratory Distress Syndrome by Nick, Jerry A, Caceres, Silvia M, Kret, Jennifer E, Poch, Katie R, Strand, Matthew, Faino, Anna V, Nichols, David P, Saavedra, Milene T, Taylor-Cousar, Jennifer L, Geraci, Mark W, Burnham, Ellen L, Fessler, Michael B, Suratt, Benjamin T, Abraham, Edward, Moss, Marc, Malcolm, Kenneth C

“…Acute Respiratory Distress Syndrome (ARDS) severity may be influenced by heterogeneity of neutrophil activation. Interferon-stimulated genes (ISG) are a broad…”
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Pulmonary Stromal-Derived Factor-1 Expression and Effect on Neutrophil Recruitment during Acute Lung Injury by Petty, Joseph M, Sueblinvong, Viranuj, Lenox, Christopher C, Jones, Christine C, Cosgrove, Gregory P, Cool, Carlyne D, Rai, Pradeep R, Brown, Kevin K, Weiss, Daniel J, Poynter, Matthew E, Suratt, Benjamin T

“…The severe and protracted inflammation that characterizes acute lung injury (ALI) is driven by the ongoing recruitment of neutrophils to the lung. Although…”
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Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis by Suratt, Benjamin T., Petty, Joseph M., Young, Scott K., Malcolm, Kenneth C., Lieber, Jonathan G., Nick, Jerry A., Gonzalo, Jose-Angel, Henson, Peter M., Worthen, G. Scott

“…The bone marrow is the primary site for neutrophil production and release into the circulation. Because the CXC chemokine receptor-4/stromal derived factor-1…”
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Storage conditions of high‐fat diets affect pulmonary inflammation by Kokoszynska, Marta, Ubags, Niki D., Bivona, Joseph J., Ventrone, Sebastian, Reed, Leah F., Dixon, Anne E., Wargo, Matthew J., Poynter, Matthew E., Suratt, Benjamin T.

“…Obesity alters the risks and outcomes of inflammatory lung diseases. It is important to accurately recapitulate the obese state in animal models to understand…”
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Human Pulmonary Chimerism after Hematopoietic Stem Cell Transplantation by Suratt, Benjamin T, Cool, Carlyne D, Serls, Amanda E, Chen, Lin, Varella-Garcia, Marileila, Shpall, Elizabeth J, Brown, Kevin K, Worthen, G. Scott

“…Many of the body's tissues once thought to be only locally regenerative may, in fact, be actively replaced by circulating stem cells after hematopoietic stem…”
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Greasing the Way: The ABCs of HSPC Efflux from the Marrow by Suratt, Benjamin T., Fessler, Michael B.

“…In this issue of Cell Stem Cell, Westerterp et al. demonstrate that cholesterol flux through splenic phagocytes regulates hematopoietic stem and multipotential…”
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The endogenous Th17 response in NO2-promoted allergic airway disease is dispensable for airway hyperresponsiveness and distinct from Th17 adoptive transfer by Martin, Rebecca A, Ather, Jennifer L, Daggett, Rebecca, Hoyt, Laura, Alcorn, John F, Suratt, Benjamin T, Weiss, Daniel J, Lundblad, Lennart K A, Poynter, Matthew E

“…Severe, glucocorticoid-resistant asthma comprises 5-7% of patients with asthma. IL-17 is a biomarker of severe asthma, and the adoptive transfer of Th17 cells…”
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Mouse Modeling of Obese Lung Disease. Insights and Caveats by Suratt, Benjamin T

“…As the obesity epidemic has worsened, its impact on lung health and disease has become progressively evident. The interactions between obesity and the…”
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