Search Results - "Surani, M Azim"

Regulatory Principles of Pluripotency: From the Ground State Up by Hackett, Jamie A., Surani, M. Azim

“…Pluripotency is the remarkable capacity of a single cell to engender all the specialized cell types of an adult organism. This property can be captured…”
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On the origin of the human germline by Kobayashi, Toshihiro, Surani, M Azim

“…In mice, primordial germ cells (PGCs), the precursors of eggs and sperm, originate from pregastrulation postimplantation embryos. By contrast, the origin of…”
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DNA methylation dynamics during the mammalian life cycle by Hackett, Jamie A., Surani, M. Azim

“…DNA methylation is dynamically remodelled during the mammalian life cycle through distinct phases of reprogramming and de novo methylation. These events enable…”
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SOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate by Irie, Naoko, Weinberger, Leehee, Tang, Walfred W.C., Kobayashi, Toshihiro, Viukov, Sergey, Manor, Yair S., Dietmann, Sabine, Hanna, Jacob H., Surani, M. Azim

“…Specification of primordial germ cells (PGCs) marks the beginning of the totipotent state. However, without a tractable experimental model, the mechanism of…”
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How to make a primordial germ cell by Magnúsdóttir, Erna, Surani, M Azim

“…Primordial germ cells (PGCs) are the precursors of sperm and eggs, which generate a new organism that is capable of creating endless new generations through…”
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A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development by Tang, Walfred W.C., Dietmann, Sabine, Irie, Naoko, Leitch, Harry G., Floros, Vasileios I., Bradshaw, Charles R., Hackett, Jamie A., Chinnery, Patrick F., Surani, M. Azim

“…Resetting of the epigenome in human primordial germ cells (hPGCs) is critical for development. We show that the transcriptional program of hPGCs is distinct…”
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Development and applications of single-cell transcriptome analysis by Tang, Fuchou, Lao, Kaiqin, Surani, M Azim

“…Dissecting the relationship between genotype and phenotype is one of the central goals in developmental biology and medicine. Transcriptome analysis is a…”
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Specification and epigenetic programming of the human germ line by Tang, Walfred W. C., Kobayashi, Toshihiro, Irie, Naoko, Dietmann, Sabine, Surani, M. Azim

“…Key Points Regulation of pluripotency and early post-implantation embryonic development have diverged between humans and mice, which might affect the mechanism…”
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Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos by Floros, Vasileios I., Pyle, Angela, Dietmann, Sabine, Wei, Wei, Tang, Walfred C. W., Irie, Naoko, Payne, Brendan, Capalbo, Antonio, Noli, Laila, Coxhead, Jonathan, Hudson, Gavin, Crosier, Moira, Strahl, Henrik, Khalaf, Yacoub, Saitou, Mitinori, Ilic, Dusko, Surani, M. Azim, Chinnery, Patrick F.

“…Mitochondrial DNA (mtDNA) mutations cause inherited diseases and are implicated in the pathogenesis of common late-onset disorders, but how they arise is not…”
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Germline and Pluripotent Stem Cells by Reik, Wolf, Surani, M Azim

“…Epigenetic mechanisms play an essential role in the germline and imprinting cycle. Germ cells show extensive epigenetic programming in preparation for the…”
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Pluripotency and X chromosome dynamics revealed in pig pre-gastrulating embryos by single cell analysis by Ramos-Ibeas, Priscila, Sang, Fei, Zhu, Qifan, Tang, Walfred W. C., Withey, Sarah, Klisch, Doris, Wood, Liam, Loose, Matt, Surani, M. Azim, Alberio, Ramiro

“…High-resolution molecular programmes delineating the cellular foundations of mammalian embryogenesis have emerged recently. Similar analysis of human embryos…”
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Epigenetic reversion of post-implantation epiblast to pluripotent embryonic stem cells by Surani, M. Azim, Bao, Siqin, Tang, Fuchou, Li, Xihe, Hayashi, Katsuhiko, Gillich, Astrid, Lao, Kaiqin

“…The pluripotent state, which is first established in the primitive ectoderm cells of blastocysts, is lost progressively and irreversibly during subsequent…”
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A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons by Sybirna, Anastasiya, Tang, Walfred W. C., Pierson Smela, Merrick, Dietmann, Sabine, Gruhn, Wolfram H., Brosh, Ran, Surani, M. Azim

“…PRDM14 is a crucial regulator of mouse primordial germ cells (mPGCs), epigenetic reprogramming and pluripotency, but its role in the evolutionarily divergent…”
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A tripartite transcription factor network regulates primordial germ cell specification in mice by Magnúsdóttir, Erna, Dietmann, Sabine, Murakami, Kazuhiro, Günesdogan, Ufuk, Tang, Fuchou, Bao, Siqin, Diamanti, Evangelia, Lao, Kaiqin, Gottgens, Berthold, Azim Surani, M.

“…Transitions in cell states are controlled by combinatorial actions of transcription factors. BLIMP1, the key regulator of primordial germ cell (PGC)…”
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Sequential enhancer state remodelling defines human germline competence and specification by Tang, Walfred W. C., Castillo-Venzor, Aracely, Gruhn, Wolfram H., Kobayashi, Toshihiro, Penfold, Christopher A., Morgan, Michael D., Sun, Dawei, Irie, Naoko, Surani, M. Azim

“…Germline–soma segregation is a fundamental event during mammalian embryonic development. Here we establish the epigenetic principles of human primordial germ…”
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Germline DNA Demethylation Dynamics and Imprint Erasure Through 5-Hydroxymethylcytosine by Hackett, Jamie A., Sengupta, Roopsha, Zylicz, Jan J., Murakami, Kazuhiro, Lee, Caroline, Down, Thomas A., Surani, M. Azim

“…Mouse primordial germ cells (PGCs) undergo sequential epigenetic changes and genome-wide DNA demethylation to reset the epigenome for totipotency. Here, we…”
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Metabolic regulation of pluripotency and germ cell fate through α‐ketoglutarate by Tischler, Julia, Gruhn, Wolfram H, Reid, John, Allgeyer, Edward, Buettner, Florian, Marr, Carsten, Theis, Fabian, Simons, Ben D, Wernisch, Lorenz, Surani, M Azim

“…An intricate link is becoming apparent between metabolism and cellular identities. Here, we explore the basis for such a link in an in vitro model for early…”
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Genome-Wide Reprogramming in the Mouse Germ Line Entails the Base Excision Repair Pathway by Hajkova, Petra, Jeffries, Sean J, Lee, Caroline, Miller, Nigel, Jackson, Stephen P, Surani, M. Azim

“…Genome-wide active DNA demethylation in primordial germ cells (PGCs), which reprograms the epigenome for totipotency, is linked to changes in nuclear…”
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Tracing the Derivation of Embryonic Stem Cells from the Inner Cell Mass by Single-Cell RNA-Seq Analysis by Tang, Fuchou, Barbacioru, Catalin, Bao, Siqin, Lee, Caroline, Nordman, Ellen, Wang, Xiaohui, Lao, Kaiqin, Surani, M. Azim

“…During the transition from the inner cell mass (ICM) cells of blastocysts to pluripotent embryonic stem cells (ESCs) in vitro, a normal developmental program…”
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Tracing the transitions from pluripotency to germ cell fate with CRISPR screening by Hackett, Jamie A., Huang, Yun, Günesdogan, Ufuk, Gretarsson, Kristjan A., Kobayashi, Toshihiro, Surani, M. Azim

“…Early mammalian development entails transit through naive pluripotency towards post-implantation epiblast, which subsequently gives rise to primordial germ…”
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