Search Results - "Sur, Inderpreet"

Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing by Joost, Simon, Jacob, Tina, Sun, Xiaoyan, Annusver, Karl, La Manno, Gioele, Sur, Inderpreet, Kasper, Maria

“…Epithelial tissues, such as the skin, rely on cellular plasticity of stem cells (SCs) from different niches to restore tissue function after injury. How these…”
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Transcription Factor Binding in Human Cells Occurs in Dense Clusters Formed around Cohesin Anchor Sites by Yan, Jian, Enge, Martin, Whitington, Thomas, Dave, Kashyap, Liu, Jianping, Sur, Inderpreet, Schmierer, Bernhard, Jolma, Arttu, Kivioja, Teemu, Taipale, Minna, Taipale, Jussi

“…During cell division, transcription factors (TFs) are removed from chromatin twice, during DNA synthesis and during condensation of chromosomes. How TFs can…”
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Mice Lacking a Myc Enhancer That Includes Human SNP rs6983267 Are Resistant to Intestinal Tumors by Sur, Inderpreet Kaur, Hallikas, Outi, Vähärautio, Anna, Yan, Jian, Turunen, Mikko, Enge, Martin, Taipale, Minna, Karhu, Auli, Aaltonen, Lauri A., Taipale, Jussi

“…Multiple cancer-associated single-nucleotide polymorphisms (SNPs) have been mapped to conserved sequences within a 500-kilobase region upstream of the MYC…”
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Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth by Dave, Kashyap, Sur, Inderpreet, Yan, Jian, Zhang, Jilin, Kaasinen, Eevi, Zhong, Fan, Blaas, Leander, Li, Xiaoze, Kharazi, Shabnam, Gustafsson, Charlotte, De Paepe, Ayla, Månsson, Robert, Taipale, Jussi

“…The gene desert upstream of the oncogene on chromosome 8q24 contains susceptibility loci for several major forms of human cancer. The region shows high…”
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A protein activity assay to measure global transcription factor activity reveals determinants of chromatin accessibility by Wei, Bei, Jolma, Arttu, Sahu, Biswajyoti, Orre, Lukas M, Zhong, Fan, Zhu, Fangjie, Kivioja, Teemu, Sur, Inderpreet, Lehtiö, Janne, Taipale, Minna, Taipale, Jussi

“…A method to analyze global transcription factor activity in cells reveals that a small number of factors determines the landscape of accessible chromatin. No…”
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Severe liver disease resembling PSC in mice with K5-Cre mediated deletion of Krüppel-like factor 5 (Klf5) by Bergström, Åsa, Gerling, Marco, Van Hul, Noémi, Fernández Moro, Carlos, Rozell, Björn, Toftgård, Rune, Sur, Inderpreet

“…Chronic cholestatic liver diseases including primary sclerosing cholangitis (PSC) present a complex spectrum with regards to the cause, age of manifestation…”
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Kruppel-Like Factors 4 and 5: Unity in Diversity by Sur, Inderpreet

“…Kruppel-like factors (Klf) 4 and 5 belong to a family of zinc finger-containing transcription factors that share homology with the Drosophila gene Kruppel…”
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Tumor Necrosis Factor Receptor 1-Mediated Signaling Is Required for Skin Cancer Development Induced by NF-κB Inhibition by Lind, Maria H., Rozell, Björn, Robert P. A. Wallin, van Hogerlinden, Max, Ljunggren, Hans-Gustaf, Toftgård, Rune, Sur, Inderpreet, Goeddel, David V.

“…NF-κB signaling plays an important role in skin development and epidermal growth control. Moreover, inhibition of NF-κB signaling in murine epidermal…”
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Epidermal and craniofacial defects in mice overexpressing Klf5 in the basal layer of the epidermis by Sur, Inderpreet, Rozell, Björn, Jaks, Viljar, Bergström, Asa, Toftgård, Rune

“…Krüppel-like factor5 (Klf5) is a zinc-finger transcription factor normally expressed in the skin. Here, we show that overexpression of Klf5 in the basal layer…”
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The role of enhancers in cancer by Sur, Inderpreet, Taipale, Jussi

“…Key Points Enhancer malfunction is a key process that drives the aberrant regulation of oncogenes in cancer. Enhancer variants contribute more than any other…”
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Lessons from Functional Analysis of Genome-Wide Association Studies by SUR, Inderpreet, TUUPANEN, Sari, WHITINGTON, Thomas, AALTONEN, Lauri A, TAIPALE, Jussi

“…Most cancer-associated single-nucleotide polymorphisms (SNP) identified using genome-wide association studies are located outside of protein-coding regions,…”
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The Two-Faced NF-κB in the Skin by Sur, Inderpreet, Ulvmar, Maria, Toftgård, Rune

“…The role of the transcription factor NF-κ B, particularly its coupling to inflammation and cancer, has generated considerable interest in recent years. NF-κ B…”
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Timed NF-[kappa]B Inhibition in Skin Reveals Dual Independent Effects on Development of HED/EDA and Chronic Inflammation by Ulvmar, Maria H, Sur, Inderpreet, Mémet, Sylvie, Toftgård, Rune

“…We have shown earlier that inhibiting NF-kappaB activity in murine basal keratinocytes leads to hyperproliferation, inflammation, and cancer in a tumor…”
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The Two-Faced NF- mu B in the Skin by Sur, Inderpreet, Ulvmar, Maria, Toftgard, Rune

“…The role of the transcription factor NF- mu B, particularly its coupling to inflammation and cancer, has generated considerable interest in recent years. NF-…”
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Timed NF-κB Inhibition in Skin Reveals Dual Independent Effects on Development of HED/EDA and Chronic Inflammation by Ulvmar, Maria H., Sur, Inderpreet, Mémet, Sylvie, Toftgård, Rune

“…We have shown earlier that inhibiting NF-κB activity in murine basal keratinocytes leads to hyperproliferation, inflammation, and cancer in a tumor necrosis…”
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Inhibition of NF-kappaB signaling interferes with phorbol ester-induced growth arrest of keratinocytes in a TNFR1-independent manner by Sur, Inderpreet, Ulvmar, Maria, Jungedal, Roger, Toftgård, Rune

“…A skin-specific block in NF-kappaB signaling leads to hyperproliferation of the keratinocytes, inflammation, and spontaneous development of squamous cell…”
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Inhibition of NF-κB signaling interferes with phorbol ester-induced growth arrest of keratinocytes in a TNFR1-independent manner by Sur, Inderpreet, Ulvmar, Maria, Jungedal, Roger, Toftgård, Rune

“…A skin-specific block in NF-κB signaling leads to hyperproliferation of the keratinocytes, inflammation, and spontaneous development of squamous cell carcinoma…”
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Human Krüppel-like factor5/KLF5: Synergy with NF-κB/Rel factors and expression in human skin and hair follicles by Sur, Inderpreet, Birgitte Undén, A., Toftgård, Rune

“…In this report we describe the identification of Krüppel-like factor 5 (KLF5/BTEB2) in a yeast one-hybrid screen using a keratinocyte-specific, NF-κB binding…”
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Human Kruppel-like factor5/KLF5: Synergy with NK-(kappa)B/Rel factors and expression in human skin and hair follicles by Sur, Inderpreet, Unden, A Birgitte, Toftgard, Rune

“…In this report we describe the identification of Kruppel-like factor 5 (KLF5/BTEB2) in a yeast one-hybrid screen using a keratinocyte-specific, NF-kappaB…”
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Timed NF-kappaB inhibition in skin reveals dual independent effects on development of HED/EDA and chronic inflammation by Ulvmar, Maria H, Sur, Inderpreet, Mémet, Sylvie, Toftgård, Rune

“…We have shown earlier that inhibiting NF-kappaB activity in murine basal keratinocytes leads to hyperproliferation, inflammation, and cancer in a tumor…”
Get full text