Search Results - "Supplee, Julianna"

False positive plasma genotyping due to clonal hematopoiesis by Hu, Yuebi, Ulrich, Bryan, Supplee, Julianna, Kuang, Yanan, Lizotte, Patrick H, Feeney, Nora, Guibert, Nicolas, Awad, Mark M, Wong, Kwok-Kin, Janne, Pasi A, Paweletz, Cloud Peter, Oxnard, Geoffrey R

“…Plasma cell-free DNA (cfDNA) genotyping is increasingly used in cancer care, but assay accuracy is debated. Because most cfDNA is derived from peripheral blood…”
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Sensitivity of next-generation sequencing assays detecting oncogenic fusions in plasma cell-free DNA by Supplee, Julianna G., Milan, Marina S.D., Lim, Lee P., Potts, Kristy T., Sholl, Lynette M., Oxnard, Geoffrey R., Paweletz, Cloud P.

“…•Next-generation sequencing (NGS) of cell-free DNA could expand access to precision medicine.•Technical differences between plasma NGS assays are poorly…”
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Salivary HPV DNA informs locoregional disease status in advanced HPV-associated oropharyngeal cancer by Hanna, Glenn J., Lau, Christie J., Mahmood, Umair, Supplee, Julianna G., Mogili, Abhishek R., Haddad, Robert I., Jänne, Pasi A., Paweletz, Cloud P.

“…•Salivary HPV DNA levels align with local disease burden in HPV oropharyngeal cancer.•The rise and fall of salivary HPV DNA often predicts treatment response…”
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Plasma IL-6 changes correlate to PD-1 inhibitor responses in NSCLC by Keegan, Alissa, Ricciuti, Biagio, Garden, Padric, Cohen, Limor, Nishihara, Reiko, Adeni, Anika, Paweletz, Cloud, Supplee, Julianna, Jänne, Pasi A, Severgnini, Mariano, Awad, Mark M, Walt, David R

“…BackgroundBlood-based biomarkers of anti-solid tumor immune checkpoint blockade (ICB) response are lacking. We hypothesized that changes in systemic cytokine…”
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ACLY alternative splicing correlates with cancer phenotypes by Supplee, Julianna G., Affronti, Hayley C., Duan, Richard, Brooks, Rebekah C., Stine, Zachary E., Nguyen, Phuong T.T., Pinheiro, Laura V., Noji, Michael C., Drummond, Jack M., Huang, Kevin, Schultz, Kollin, Dang, Chi V., Marmorstein, Ronen, Wellen, Kathryn E.

“…ATP-citrate lyase (ACLY) links carbohydrate and lipid metabolism and provides nucleocytosolic acetyl-CoA for protein acetylation. ACLY has two major splice…”
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Protein biomarkers and alternatively methylated cell-free DNA detect early stage pancreatic cancer by Ben-Ami, Roni, Wang, Qiao-Li, Zhang, Jinming, Supplee, Julianna G, Fahrmann, Johannes F, Lehmann-Werman, Roni, Brais, Lauren K, Nowak, Jonathan, Yuan, Chen, Loftus, Maureen, Babic, Ana, Irajizad, Ehsan, Davidi, Tal, Zick, Aviad, Hubert, Ayala, Neiman, Daniel, Piyanzin, Sheina, Gal-Rosenberg, Ofer, Horn, Amit, Shemer, Ruth, Glaser, Benjamin, Boos, Natalia, Jajoo, Kunal, Lee, Linda, Clancy, Thomas E, Rubinson, Douglas A, Ng, Kimmie, Chabot, John A, Kastrinos, Fay, Kluger, Michael, Aguirre, Andrew J, Jänne, Pasi A, Bardeesy, Nabeel, Stanger, Ben, O'Hara, Mark H, Till, Jacob, Maitra, Anirban, Carpenter, Erica L, Bullock, Andrea J, Genkinger, Jeanine, Hanash, Samir M, Paweletz, Cloud P, Dor, Yuval, Wolpin, Brian M

“…Pancreatic ductal adenocarcinoma (PDAC) is commonly diagnosed at an advanced stage. Liquid biopsy approaches may facilitate detection of early stage PDAC when…”
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Plasma ctDNA Response Is an Early Marker of Treatment Effect in Advanced NSCLC by Cheng, Michael L, Lau, Christie J, Milan, Marina S D, Supplee, Julianna G, Riess, Jonathan W, Bradbury, Penelope A, Jänne, Pasi A, Oxnard, Geoffrey R, Paweletz, Cloud P

“…Plasma circulating tumor DNA (ctDNA) analysis is routine for genotyping of advanced non-small-cell lung cancer (NSCLC); however, early response assessment…”
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Molecular mechanism of N-terminal acetylation by the ternary NatC complex by Deng, Sunbin, Gottlieb, Leah, Pan, Buyan, Supplee, Julianna, Wei, Xuepeng, Petersson, E James, Marmorstein, Ronen

“…Protein N-terminal acetylation is predominantly a ribosome-associated modification, with NatA-E serving as the major enzymes. NatC is the most unusual of these…”
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Denaturation-Enhanced Droplet Digital PCR for Liquid Biopsies by Fitarelli-Kiehl, Mariana, Yu, Fangyan, Ashtaputre, Ravina, Leong, Ka Wai, Ladas, Ioannis, Supplee, Julianna, Paweletz, Cloud, Mitra, Devarati, Schoenfeld, Jonathan D, Parangi, Sareh, Makrigiorgos, G Mike

“…Although interest in droplet-digital PCR technology (ddPCR) for cell-free circulating DNA (cfDNA) analysis is burgeoning, the technology is compromised by…”
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Liquid biopsy of fine-needle aspiration supernatant for lung cancer genotyping by Guibert, Nicolas, Tsukada, Hisashi, Hwang, David H., Chambers, Emily, Cibas, Edmund S., Bale, Tejus, Supplee, Julianna, Ulrich, Bryan, Sholl, Lynette M., Paweletz, Cloud P., Oxnard, Geoffrey R.

“…•FNA supernatant, usually discarded, is a rich source of cell-free DNA.•Driver and resistance mutations were detected by NGS and ddPCR in supernatant.•This…”
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Abstract 2581: Plasma HPV cell free DNA as an earlier predictor of treatment response in advanced oropharyngeal cancer by Hanna, Glenn J., Supplee, Julianna G., Kuang, Yanan, Geary, Kate, Janne, Pasi A., Haddad, Robert I., Paweletz, Cloud P.

“…Abstract Purpose: Human papillomavirus (HPV) is associated with the majority of oropharyngeal squamous cell carcinomas (OPSCC), with a rising incidence of…”
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Abstract 1374: Building an effective concordance study: Plasma Next Generation Sequencing (NGS) for oncogenic fusion detection in non-small cell lung carcinoma (NSCLC) by Supplee, Julianna G., Milan, Marina S., Potts, Kristy T., Sholl, Lynette M., Shaffer, Tristan S., Lim, Lee P., Janne, Pasi A., Oxnard, Geoffrey R., Paweletz, Cloud P.

“…Abstract Background: Non-invasive genotyping of cell-free DNA (cfDNA) is increasingly used in cancer care as tumor biopsies may be inadequate or unavailable…”
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Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions by Gong, Binsheng, Li, Dan, Kusko, Rebecca, Novoradovskaya, Natalia, Zhang, Yifan, Wang, Shangzi, Pabón-Peña, Carlos, Zhang, Zhihong, Lai, Kevin, Cai, Wanshi, LoCoco, Jennifer S, Lader, Eric, Richmond, Todd A, Mittal, Vinay K, Liu, Liang-Chun, Johann, Jr, Donald J, Willey, James C, Bushel, Pierre R, Yu, Ying, Xu, Chang, Chen, Guangchun, Burgess, Daniel, Cawley, Simon, Giorda, Kristina, Haseley, Nathan, Qiu, Fujun, Wilkins, Katherine, Arib, Hanane, Attwooll, Claire, Babson, Kevin, Bao, Longlong, Bao, Wenjun, Lucas, Anne Bergstrom, Best, Hunter, Bhandari, Ambica, Bisgin, Halil, Blackburn, James, Blomquist, Thomas M, Boardman, Lisa, Burgher, Blake, Butler, Daniel J, Chang, Chia-Jung, Chaubey, Alka, Chen, Tao, Chierici, Marco, Chin, Christopher R, Close, Devin, Conroy, Jeffrey, Cooley Coleman, Jessica, Craig, Daniel J, Crawford, Erin, Del Pozo, Angela, Deveson, Ira W, Duncan, Daniel, Eterovic, Agda Karina, Fan, Xiaohui, Foox, Jonathan, Furlanello, Cesare, Ghosal, Abhisek, Glenn, Sean, Guan, Meijian, Haag, Christine, Hang, Xinyi, Happe, Scott, Hennigan, Brittany, Hipp, Jennifer, Hong, Huixiao, Horvath, Kyle, Hu, Jianhong, Hung, Li-Yuan, Jarosz, Mirna, Kerkhof, Jennifer, Kipp, Benjamin, Kreil, David Philip, Łabaj, Paweł, Lapunzina, Pablo, Li, Peng, Li, Quan-Zhen, Li, Weihua, Li, Zhiguang, Liang, Yu, Liu, Shaoqing, Liu, Zhichao, Ma, Charles, Marella, Narasimha, Martín-Arenas, Rubén, Megherbi, Dalila B, Meng, Qingchang, Mieczkowski, Piotr A, Morrison, Tom, Muzny, Donna, Ning, Baitang, Parsons, Barbara L, Paweletz, Cloud P, Pirooznia, Mehdi, Qu, Wubin, Raymond, Amelia, Rindler, Paul, Ringler, Rebecca, Sadikovic, Bekim

“…Targeted sequencing using oncopanels requires comprehensive assessments of accuracy and detection sensitivity to ensure analytical validity. By employing…”
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Abstract 4578: Development of a rapid clinical grade assay to detect and monitor secondary KIT mutations in circulating free DNA (cfDNA) for personalization of targeted therapy for gastrointestinal stromal tumors (GIST) by Marino-Enriquez, Adrian, George, Suzanne, Supplee, Julianna, Heavey, Grace, Janne, Pasi A., Raut, Chandrajit, Fletcher, Jonathan, Demetri, George D., Paweletz, Cloud P., Kuang, Yanan

“…Abstract Introduction: Genotype-directed therapies are revolutionizing care for gastrointestinal stromal tumors (GIST). Somatic mutations in KIT exons (ex) 11…”
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Abstract 3711: Molecular and cancer-related roles of ATP-citrate lyase exon 14 by Supplee, Julianna G., Affronti, Hayley C., Duan, Richard, Brooks, Rebekah C., Nguyen, Phuong, Schultz, Kollin, Marmorstein, Ronen, Wellen, Kathryn E.

“…Abstract Introduction: ATP-citrate lyase (ACLY) links carbohydrate and lipid metabolism as well as provides acetyl-CoA necessary for histone acetylation,…”
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