Search Results - "Supinski, Gerald S"

Diaphragm weakness in mechanically ventilated critically ill patients by Supinski, Gerald S, Callahan, Leigh Ann

“…Studies indicate that mechanically ventilated patients develop significant diaphragm muscle weakness, but the etiology of weakness and its clinical impact…”
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A randomized controlled trial to determine whether beta-hydroxy-beta-methylbutyrate and/or eicosapentaenoic acid improves diaphragm and quadriceps strength in critically Ill mechanically ventilated patients by Supinski, Gerald S, Netzel, Paul F, Westgate, Philip M, Schroder, Elizabeth A, Wang, Lin, Callahan, Leigh Ann

“…Intensive care unit acquired weakness is a serious problem, contributing to respiratory failure and reductions in ambulation. Currently, there is no…”
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Free radical-mediated skeletal muscle dysfunction in inflammatory conditions by Supinski, Gerald S, Callahan, Leigh A

“…Department of Medicine, Medical College of Georgia, Augusta, Georgia Loss of functional capacity of skeletal muscle is a major cause of morbidity in patients…”
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Calpain Activation Contributes to Endotoxin-Induced Diaphragmatic Dysfunction by Supinski, Gerald S, Callahan, Leigh Ann

“…Calpain activation occurs in skeletal muscle in response to infection, but it is unknown if calpain inhibition improves muscle functional capacity. We…”
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Neutral sphingomyelinase 2 is required for cytokine-induced skeletal muscle calpain activation by Supinski, Gerald S, Alimov, Alexander P, Wang, Lin, Song, Xiao-Hong, Callahan, Leigh A

“…Calpain contributes to infection-induced diaphragm dysfunction but the upstream mechanism(s) responsible for calpain activation are poorly understood. It is…”
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Mitochondria and Critical Illness by Supinski, Gerald S, Schroder, Elizabeth A, Callahan, Leigh Ann

“…Classically, mitochondria have largely been believed to influence the development of illness by modulating cell metabolism and determining the rate of…”
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Caspase activation contributes to endotoxin-induced diaphragm weakness by Supinski, Gerald S, Callahan, Leigh A

“…Division of Pulmonary and Critical Care Medicine, Department of Medicine, Medical College of Georgia, Augusta, Georgia Submitted 6 October 2005 ; accepted in…”
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Diaphragm Dysfunction in Critical Illness by Supinski, Gerald S., Morris, Peter E., Dhar, Sanjay, Callahan, Leigh Ann

“…The diaphragm is the major muscle of inspiration, and its function is critical for optimal respiration. Diaphragmatic failure has long been recognized as a…”
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Sepsis-induced myopathy by Callahan, Leigh Ann, Supinski, Gerald S

“…Sepsis is a major cause of morbidity and mortality in critically ill patients, and despite advances in management, mortality remains high. In survivors, sepsis…”
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Diaphragmatic free radical generation increases in an animal model of heart failure by Supinski, Gerald S, Callahan, Leigh A

“…Pulmonary and Critical Care Division, Department of Medicine Medical College of Georgia, Augusta, Georgia Submitted 11 October 2004 ; accepted in final form 15…”
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Correlation of maximal inspiratory pressure to transdiaphragmatic twitch pressure in intensive care unit patients by Supinski, Gerald S, Westgate, Phillip, Callahan, Leigh A

“…Respiratory muscle weakness contributes to respiratory failure in ICU patients. Unfortunately, assessment of weakness is difficult since the most objective…”
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MitoTEMPOL, a mitochondrial targeted antioxidant, prevents sepsis-induced diaphragm dysfunction by Supinski, Gerald S, Wang, Lin, Schroder, Elizabeth A, Callahan, Leigh Ann P

“…Clinical studies indicate that sepsis-induced diaphragm dysfunction is a major contributor to respiratory failure in mechanically ventilated patients…”
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Skeletal muscle-specific calpastatin overexpression mitigates muscle weakness in aging and extends life span by Schroder, Elizabeth A, Wang, Lin, Wen, Yuan, Callahan, Leigh Ann P, Supinski, Gerald S

“…Calpain activation has been postulated as a potential contributor to the loss of muscle mass and function associated with both aging and disease, but…”
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SS31, a mitochondrially targeted antioxidant, prevents sepsis-induced reductions in diaphragm strength and endurance by Supinski, Gerald S, Wang, Lin, Schroder, Elizabeth A, Callahan, Leigh Ann P

“…Sepsis-induced diaphragm dysfunction contributes to respiratory failure and mortality in critical illness. There are no treatments for this form of diaphragm…”
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Hyperglycemia-induced diaphragm weakness is mediated by oxidative stress by Callahan, Leigh A, Supinski, Gerald S

“…A major consequence of ICU-acquired weakness (ICUAW) is diaphragm weakness, which prolongs the duration of mechanical ventilation. Hyperglycemia (HG) is a risk…”
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Mitoquinone mesylate (MitoQ) prevents sepsis-induced diaphragm dysfunction by Supinski, Gerald S, Schroder, Elizabeth A, Wang, Lin, Morris, Andrew J, Callahan, Leigh Ann P

“…Sepsis-induced diaphragm dysfunction is a major contributor to respiratory failure in mechanically ventilated patients. There are no pharmacological treatments…”
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Does Standard Physical Therapy Increase Quadriceps Strength in Chronically Ventilated Patients? A Pilot Study by Supinski, Gerald S., Valentine, Emily N., Netzel, Paul F., Schroder, Elizabeth A., Wang, Lin, Callahan, Leigh Ann

“…OBJECTIVES:Physical therapy is standard care for mechanically ventilated patients, but there is no evidence, using nonvolitional, objective measurements, that…”
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Calcium-dependent phospholipase A2 modulates infection-induced diaphragm dysfunction by Supinski, Gerald S, Alimov, Alexander P, Wang, Lin, Song, Xiao-Hong, Callahan, Leigh A

“…Calpain activation contributes to the development of infection-induced diaphragm weakness, but the mechanisms by which infections activate calpain are poorly…”
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Magnetic twitch assessment of diaphragm and quadriceps weakness in critically ill mechanically ventilated patients by Supinski, Gerald S., Netzel, Paul F., Westgate, Philip M., Schroder, Elizabeth A., Wang, Lin, Callahan, Leigh Ann

“…•This study employed magnetic stimulation techniques to assess limb and diaphragm strength in critically ill mechanically ventilated patients.•Leg muscle…”
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Early Mobilization in the ICU: Help or Hype? by Callahan, Leigh A., Supinski, Gerald S.

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