Search Results - "Suomalainen, Maarit"

Virus Infection Variability by Single-Cell Profiling by Suomalainen, Maarit, Greber, Urs F

“…Cell-to-cell variability of infection has long been known, yet it has remained one of the least understood phenomena in infection research. It impacts on…”
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The UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections by Prasad, Vibhu, Suomalainen, Maarit, Jasiqi, Yllza, Hemmi, Silvio, Hearing, Patrick, Hosie, Louise, Burgert, Hans-Gerhard, Greber, Urs F.

“…Persistent viruses cause chronic disease, and threaten the lives of immunosuppressed individuals. Here, we elucidate a mechanism supporting the persistence of…”
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Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control by Schmid, Markus, Ernst, Patrick, Honegger, Annemarie, Suomalainen, Maarit, Zimmermann, Martina, Braun, Lukas, Stauffer, Sarah, Thom, Cristian, Dreier, Birgit, Eibauer, Matthias, Kipar, Anja, Vogel, Viola, Greber, Urs F., Medalia, Ohad, Plückthun, Andreas

“…Most systemic viral gene therapies have been limited by sequestration and degradation of virions, innate and adaptive immunity, and silencing of therapeutic…”
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The adenovirus major core protein VII is dispensable for virion assembly but is essential for lytic infection by Ostapchuk, Philomena, Suomalainen, Maarit, Zheng, Yueting, Boucke, Karin, Greber, Urs F, Hearing, Patrick

“…The Adenovirus (Ad) genome within the capsid is tightly associated with a virus-encoded, histone-like core protein-protein VII. Two other Ad core proteins, V…”
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Drifting motions of the adenovirus receptor CAR and immobile integrins initiate virus uncoating and membrane lytic protein exposure by Burckhardt, Christoph J, Suomalainen, Maarit, Schoenenberger, Philipp, Boucke, Karin, Hemmi, Silvio, Greber, Urs F

“…Viral particle binding to plasma membrane receptors elicits virus motions, recruits signaling proteins, and triggers membrane bending and fission, finally…”
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Tracking Viral Genomes in Host Cells at Single-Molecule Resolution by Wang, I-Hsuan, Suomalainen, Maarit, Andriasyan, Vardan, Kilcher, Samuel, Mercer, Jason, Neef, Anne, Luedtke, Nathan W., Greber, Urs F.

“…Viral DNA trafficking in cells has large impacts on physiology and disease development. Current methods lack the resolution and accuracy to visualize and…”
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Fluorescence Tracking of Genome Release during Mechanical Unpacking of Single Viruses by Ortega-Esteban, Alvaro, Bodensiek, Kai, San Martín, Carmen, Suomalainen, Maarit, Greber, Urs F, de Pablo, Pedro J, Schaap, Iwan A. T

“…Viruses package their genome in a robust protein coat to protect it during transmission between cells and organisms. In a reaction termed uncoating, the virus…”
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The E3 Ubiquitin Ligase Mind Bomb 1 Controls Adenovirus Genome Release at the Nuclear Pore Complex by Bauer, Michael, Flatt, Justin W., Seiler, Daria, Cardel, Bettina, Emmenlauer, Mario, Boucke, Karin, Suomalainen, Maarit, Hemmi, Silvio, Greber, Urs F.

“…Adenoviruses (AdVs) cause respiratory, ocular, and gastrointestinal tract infection and inflammation in immunocompetent people and life-threatening disease…”
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Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor by Stichling, Nicole, Suomalainen, Maarit, Flatt, Justin W, Schmid, Markus, Pacesa, Martin, Hemmi, Silvio, Jungraithmayr, Wolfgang, Maler, Mareike D, Freudenberg, Marina A, Plückthun, Andreas, May, Tobias, Köster, Mario, Fejer, György, Greber, Urs F

“…Macrophages are a diverse group of phagocytic cells acting in host protection against stress, injury, and pathogens. Here, we show that the scavenger receptor…”
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Dynamic competition for hexon binding between core protein VII and lytic protein VI promotes adenovirus maturation and entry by Hernando-Pérez, Mercedes, Martín-González, Natalia, Pérez-Illana, Marta, Suomalainen, Maarit, Condezo, Gabriela N., Ostapchuk, Philomena, Gallardo, José, Menéndez, Margarita, Greber, Urs F., Hearing, Patrick, de Pablo, Pedro J., San Martín, Carmen

“…Adenovirus minor coat protein VI contains a membrane-disrupting peptide that is inactive when VI is bound to hexon trimers. Protein VI must be released during…”
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A Direct and Versatile Assay Measuring Membrane Penetration of Adenovirus in Single Cells by Suomalainen, Maarit, Luisoni, Stefania, Boucke, Karin, Bianchi, Sarah, Engel, Daniel A, Greber, Urs F

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Preexisting cell state rather than stochastic noise confers high or low infection susceptibility of human lung epithelial cells to adenovirus by Petkidis, Anthony, Suomalainen, Maarit, Andriasyan, Vardan, Singh, Abhyudai, Greber, Urs F

“…Viruses display large variability across all stages of their life cycle, including entry, gene expression, replication, assembly, and egress. We previously…”
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Plaque2.0-A High-Throughput Analysis Framework to Score Virus-Cell Transmission and Clonal Cell Expansion by Yakimovich, Artur, Andriasyan, Vardan, Witte, Robert, Wang, I-Hsuan, Prasad, Vibhu, Suomalainen, Maarit, Greber, Urs F

“…Classical plaque assay measures the propagation of infectious agents across a monolayer of cells. It is dependent on cell lysis, and limited by user-specific…”
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Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages by Maler, Mareike D, Nielsen, Peter J, Stichling, Nicole, Cohen, Idan, Ruzsics, Zsolt, Wood, Connor, Engelhard, Peggy, Suomalainen, Maarit, Gyory, Ildiko, Huber, Michael, Müller-Quernheim, Joachim, Schamel, Wolfgang W A, Gordon, Siamon, Jakob, Thilo, Martin, Stefan F, Jahnen-Dechent, Willi, Greber, Urs F, Freudenberg, Marina A, Fejer, György

“…The scavenger receptor MARCO is expressed in several subsets of naive tissue-resident macrophages and has been shown to participate in the recognition of…”
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Lipid Rafts and Assembly of Enveloped Viruses by Suomalainen, Maarit

“…The plasma membrane, late secretory pathway and endosomal compartments contain detergent‐insoluble raft microdomains that are enriched in sphingolipids and…”
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Sequence-Specific Features of Short Double-Strand, Blunt-End RNAs Have RIG-I- and Type 1 Interferon-Dependent or -Independent Anti-Viral Effects by Kannan, Abhilash, Suomalainen, Maarit, Volle, Romain, Bauer, Michael, Amsler, Marco, Trinh, Hung V, Vavassori, Stefano, Schmid, Jana Pachlopnik, Vilhena, Guilherme, Marín-González, Alberto, Perez, Ruben, Franceschini, Andrea, Mering, Christian von, Hemmi, Silvio, Greber, Urs F

“…Pathogen-associated molecular patterns, including cytoplasmic DNA and double-strand (ds)RNA trigger the induction of interferon (IFN) and antiviral states…”
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Single entity resolution valving of nanoscopic species in liquids by Eberle, Patric, Höller, Christian, Müller, Philipp, Suomalainen, Maarit, Greber, Urs F., Eghlidi, Hadi, Poulikakos, Dimos

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Microtubule-Dependent Plus- And Minus End-Directed Motilities Are Competing Processes for Nuclear Targeting of Adenovirus by Suomalainen, Maarit, Nakano, Michel Y., Keller, Stephan, Boucke, Karin, Stidwill, Robert P., Greber, Urs F.

“…Adenovirus (Ad) enters target cells by receptor-mediated endocytosis, escapes to the cytosol, and then delivers its DNA genome into the nucleus. Here we…”
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Erratum for Maler et al., "Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages" by Maler, Mareike D, Nielsen, Peter J, Stichling, Nicole, Cohen, Idan, Ruzsics, Zsolt, Wood, Connor, Engelhard, Peggy, Suomalainen, Maarit, Gyory, Ildiko, Huber, Michael, Müller-Quernheim, Joachim, Schamel, Wolfgang W, Gordon, Siamon, Jakob, Thilo, Martin, Stefan F, Jahnen-Dechent, Willi, Greber, Urs F, Freudenberg, Marina A, Fejer, György

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The role of the nuclear pore complex in adenovirus DNA entry by Greber, Urs F., Suomalainen, Maarit, Stidwill, Robert P., Boucke, Karin, Ebersold, Melanie W., Helenius, Ari

“…Adenovirus targets its genome to the cell nucleus by a multistep process involving endocytosis, membrane penetration and cytoplasmic transport, and finally…”
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