Bacterial Persister Cells and Development of Antibiotic Resistance in Chronic Infections: An Update

The global issue of antimicrobial resistance poses significant challenges to public health. The World Health Organization (WHO) has highlighted it as a major global health threat, causing an estimated 700,000 deaths worldwide. Understanding the multifaceted nature of antibiotic resistance is crucial...

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Bibliographic Details
Published in:	British journal of biomedical science Vol. 81; p. 12958
Main Authors:	Kunnath, Anil Philip, Suodha Suoodh, Mohamed, Chellappan, Dinesh Kumar, Chellian, Jestin, Palaniveloo, Kishneth
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 07-08-2024
Subjects:	Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use antibiotic resistance antibiotic tolerance Bacteria - drug effects Bacteria - growth & development Bacterial Infections - drug therapy Bacterial Infections - microbiology bacterial persister cells biofilms Chronic Disease chronic infections Drug Resistance, Bacterial Health Archive Humans antibiotic tolerance bacterial persister cells chronic infections antibiotic resistance biofilms
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Summary:	The global issue of antimicrobial resistance poses significant challenges to public health. The World Health Organization (WHO) has highlighted it as a major global health threat, causing an estimated 700,000 deaths worldwide. Understanding the multifaceted nature of antibiotic resistance is crucial for developing effective strategies. Several physiological and biochemical mechanisms are involved in the development of antibiotic resistance. Bacterial cells may escape the bactericidal actions of the drugs by entering a physiologically dormant state known as bacterial persistence. Recent findings in this field suggest that bacterial persistence can be one of the main sources of chronic infections. The antibiotic tolerance developed by the persister cells could tolerate high levels of antibiotics and may give rise to persister offspring. These persister offspring could be attributed to antibiotic resistance mechanisms, especially in chronic infections. This review attempts to shed light on persister-induced antibiotic resistance and the current therapeutic strategies.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	2474-0896 0967-4845 2474-0896
DOI:	10.3389/bjbs.2024.12958