Cell secretomes for wound healing and tissue regeneration: Next generation acellular based tissue engineered products

Cell secretomes for wound healing and tissue regeneration: Next generation acellular based tissue engineered products

Wound represents a significant socioeconomic burden for both affected individuals and as a whole healthcare system. Accordingly, stem cells have garnered attention due to their differentiation capacity and ability to aid tissue regeneration by releasing biologically active molecules, found in the ce...

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Bibliographic Details
Published in:Journal of Tissue Engineering Vol. 13; p. 20417314221114273
Main Authors: Md Fadilah, Nur Izzah, Mohd Abdul Kader Jailani, Muhammad Syahiran, Badrul Hisham, Muhd Aliff Iqmal, Sunthar Raj, Nithiaraj, Shamsuddin, Sharen Aini, Ng, Min Hwei, Fauzi, Mh Busra, Maarof, Manira
Format: Book Review Journal Article
Language:English
Published: London, England SAGE Publications 2022
Sage Publications Ltd
SAGE Publishing
Subjects:
Biological activity
Biomaterials
Biomedical materials
Chemokines
Exosomes
Extracellular matrix
Growth factors
Metabolites
Proteins
Regeneration (physiology)
Review
Skin
Stem cells
Tissue engineering
Wound healing
conditioned medium
tissue regeneration
wound healing
Secretomes
secreted protein
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Summary:Wound represents a significant socioeconomic burden for both affected individuals and as a whole healthcare system. Accordingly, stem cells have garnered attention due to their differentiation capacity and ability to aid tissue regeneration by releasing biologically active molecules, found in the cells’ cultivated medium which known as conditioned medium (CM) or secretomes. This acellular approach provides a huge advantage over conventional treatment options, which are mainly used cellular treatment at wound closure. Interestingly, the secretomes contained the cell-secreted proteins such as growth factors, cytokines, chemokines, extracellular matrix (ECM), and small molecules including metabolites, microvesicles, and exosomes. This review aims to provide a general view on secretomes and how it is proven to have great potential in accelerating wound healing. Utilizing the use of secretomes with its secreted proteins and suitable biomaterials for fabrications of acellular skin substitutes can be promising in treating skin loss and accelerate the healing process.
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ISSN:2041-7314
2041-7314
DOI:10.1177/20417314221114273