Search Results - "Sunter, David"

Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen by Liakath-Ali, Kifayathullah, Vancollie, Valerie E., Heath, Emma, Smedley, Damian P., Estabel, Jeanne, Sunter, David, DiTommaso, Tia, White, Jacqueline K., Ramirez-Solis, Ramiro, Smyth, Ian, Steel, Karen P., Watt, Fiona M.

“…Permanent stop-and-shop large-scale mouse mutant resources provide an excellent platform to decipher tissue phenogenomics. Here we analyse skin from 538…”
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Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength by Bassett, J H Duncan, Gogakos, Apostolos, White, Jacqueline K, Evans, Holly, Jacques, Richard M, van der Spek, Anne H, Ramirez-Solis, Ramiro, Ryder, Edward, Sunter, David, Boyde, Alan, Campbell, Michael J, Croucher, Peter I, Williams, Graham R

“…Osteoporosis is a common polygenic disease and global healthcare priority but its genetic basis remains largely unknown. We report a high-throughput…”
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Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen by Adissu, Hibret A, Estabel, Jeanne, Sunter, David, Tuck, Elizabeth, Hooks, Yvette, Carragher, Damian M, Clarke, Kay, Karp, Natasha A, Newbigging, Susan, Jones, Nora, Morikawa, Lily, White, Jacqueline K, McKerlie, Colin

“…The Mouse Genetics Project (MGP) at the Wellcome Trust Sanger Institute aims to generate and phenotype over 800 genetically modified mouse lines over the next…”
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Diurnal variation in orexin A immunoreactivity and prepro-orexin mRNA in the rat central nervous system by Taheri, Shahrad, Sunter, David, Dakin, Catherine, Moyes, Sasha, Seal, Leighton, Gardiner, James, Rossi, Michela, Ghatei, Mohammad, Bloom, Stephen

“…Orexins are a family of neuropeptides originally believed to be important mediators of food intake. The wide distribution of orexins and their receptors,…”
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Intracerebroventricular injection of neuropeptide FF, an opioid modulating neuropeptide, acutely reduces food intake and stimulates water intake in the rat by Sunter, David, Hewson, Adrian K, Lynam, Sarah, Dickson, Suzanne L

“…Neuropeptide FF (NPFF) is a mammalian peptide that is found in high concentrations in the central nervous system (CNS) and has also been detected in plasma…”
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Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes by Pugh, Perdita L, Vidgeon-Hart, Martin P, Ashmeade, Tracey, Culbert, Ainsley A, Seymour, Zoe, Perren, Marion J, Joyce, Flora, Bate, Simon T, Babin, Anna, Virley, David J, Richardson, Jill C, Upton, Neil, Sunter, David

“…Data indicates anti-oxidant, anti-inflammatory and pro-cognitive properties of noradrenaline and analyses of post-mortem brain of Alzheimer's disease (AD)…”
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Cocaine- and amphetamine-regulated transcript, glucagon-like peptide-1 and corticotrophin releasing factor inhibit feeding via agouti-related protein independent pathways in the rat by Edwards, C.M.B, Abbott, Caroline R, Sunter, David, Kim, Min-Seon, Dakin, Catherine L, Murphy, Kevin G, Abusnana, Salah, Taheri, Shahrad, Rossi, Michela, Bloom, Stephen R

“…The melanocortin-4 receptor (MC4-R) appears to be an important downstream mediator of the action of leptin. We examined to what extent the anorectic effects of…”
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The role of sphingosine-1-phosphate transporter Spns2 in immune system function by Nijnik, Anastasia, Clare, Simon, Hale, Christine, Chen, Jing, Raisen, Claire, Mottram, Lynda, Lucas, Mark, Estabel, Jeanne, Ryder, Edward, Adissu, Hibret, Adams, Niels C, Ramirez-Solis, Ramiro, White, Jacqueline K, Steel, Karen P, Dougan, Gordon, Hancock, Robert E W

“…Sphingosine-1-phosphate (S1P) is lipid messenger involved in the regulation of embryonic development, immune system functions, and many other physiological…”
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SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models by HIRST, Warren D, STEAN, Tania O, HEIDBREDER, Christian A, ATKINS, Alan R, LACROIX, Laurent P, DAWSON, Lee A, FOLEY, Andrew G, REGAN, Ciaran M, UPTON, Neil, ROGERS, Derek C, SUNTER, David, PUGH, Pippa, MOSS, Stephen F, BROMIDGE, Steven M, RILEY, Graham, SMITH, Douglas R, BARTLETT, Sarah

“…SB-399885 (N-[3,5-dichloro-2-(methoxy)phenyl]-4-(methoxy)-3-(1-piperazinyl)benzenesulfonamide) has high affinity for human recombinant and native 5-HT(6)…”
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Non-cognitive behaviours in an APP/PS1 transgenic model of Alzheimer's disease by Pugh, Perdita L., Richardson, Jill C., Bate, Simon T., Upton, Neil, Sunter, David

“…Alzheimer's disease (AD) is characterised by progressive cognitive impairment with neuropsychiatric symptoms such as anomalous motor behaviour, depression,…”
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Experimental and husbandry procedures as potential modifiers of the results of phenotyping tests by Gerdin, Anna-Karin, Igosheva, Natalia, Roberson, Laura-Anne, Ismail, Ozama, Karp, Natasha, Sanderson, Mark, Cambridge, Emma, Shannon, Carl, Sunter, David, Ramirez-Solis, Ramiro, Bussell, James, White, Jacqueline K

“…Abstract To maximize the sensitivity of detecting affects of genetic variants in mice, variables have been minimized through the use of inbred mouse lines, by…”
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Intracerebroventricular interleukin-6 treatment decreases body fat in rats by Wallenius, Kristina, Wallenius, Ville, Sunter, David, Dickson, Suzanne L, Jansson, John-Olov

“…Recently we found that interleukin-6 (IL-6) knockout mice develop mature-onset obesity and that a single intracerebroventricular (ICV) injection of IL-6…”
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Intracerebroventricular injection of apelin-13 reduces food intake in the rat by Sunter, David, Hewson, Adrian K., Dickson, Suzanne L.

“…Apelin is a peptide recently identified as a ligand for the APJ receptor, a receptor located in tissues such as the small intestine and in the hypothalamus…”
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Repeated Intracerebroventricular Administration of Glucagon-Like Peptide-1-(7–36) Amide or Exendin-(9–39) Alters Body Weight in the RatThis work was supported by the United Kingdom Medical Research Council by Meeran, Karim, O’Shea, Donal, Edwards, C. Mark B., Turton, Mandy D., Heath, Melanie M., Gunn, Irene, Abusnana, Salahedeen, Rossi, Michela, Small, Caroline J., Goldstone, Anthony P., Taylor, Gillian M., Sunter, David, Steere, Joanna, Choi, Sang Jeon, Ghatei, Mohammad A., Bloom, Stephen R.

“…Abstract Central nervous system glucagon-like peptide-1-(7–36) amide (GLP-1) administration has been reported to acutely reduce food intake in the rat. We here…”
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Diastereoselective Synthesis of All Four Isomers of 3-(4-Chlorophenyl)glutamic Acid:  Identification of the Isomers Responsible for the Potentiation of l-Homocysteic Acid-Evoked Depolarizations in Neonatal Rat Motoneurons by Jane, David E, Chalmers, David J, Howard, Judith A. K, Kilpatrick, Ian C, Sunter, David C, Thompson, Gareth A, Udvarhelyi, Peter M, Wilson, Claire, Watkins, Jeffrey C

“…All four isomers of 3-(4-chlorophenyl)glutamic acid (5−8) were prepared by diastereoselective synthesis. Addition of (6S)-(+)-bis-lactim ether 15 to…”
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Absolute Configuration of (+)-α-Methyl-4-carboxyphenylglycine (MCPG), a Metabotropic Glutamate Receptor Antagonist by Wilson, C., Howard, J. A. K., Jane, D. E., Sunter, D. C., Watkins, J. C.

“…The title compound, (+)-MCPG [(+)-alpha-(4-carboxyphenyl)-alpha-methylglycine, C10H11NO4], is an antagonist at certain subtypes of metabotropic glutamate…”
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Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes by Hayashi, Y, Sekiyama, N, Nakanishi, S, Jane, DE, Sunter, DC, Birse, EF, Udvarhelyi, PM, Watkins, JC

“…The metabotropic glutamate receptors (mGluRs) consist of at least seven different subtypes and are coupled to intracellular signal transduction via G proteins…”
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P4-327: Effects of the novel 5-HT 6 SB-742457 antagonist and the cholinesterase inhibitor donepezil in models of cognition by Ray, Alison M., Hirst, Warren D., Ahmed, Mahmood, Johnson, Christopher N., Witty, David R., Sunter, David, Quinn, Leann P., Stean, Tania O., Trail, Brenda K., Foley, Andrew, Upton, Neil, Medhurst, Andrew D., Chuang, Tsu T.

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Orexins: effects on behavior and localisation of orexin receptor 2 messenger ribonucleic acid in the rat brainstem by Sunter, David, Morgan, Irene, Edwards, C.Mark B., Dakin, Catherine L., Murphy, Kevin G., Gardiner, James, Taheri, Shahrad, Rayes, Esraa, Bloom, Stephen R.

“…The orexins are neuropeptides originally reported to be involved in the stimulation of food intake. However, analysis of orexin immunoreactive fibres have…”
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P4-327: Effects of the novel 5-HT6 SB-742457 antagonist and the cholinesterase inhibitor donepezil in models of cognition by Ray, Alison M, Hirst, Warren D, Ahmed, Mahmood, Johnson, Christopher N, Witty, David R, Sunter, David, Quinn, Leann P, Stean, Tania O, Trail, Brenda K, Foley, Andrew, Upton, Neil, Medhurst, Andrew D, Chuang, Tsu T

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