Search Results - "Sunouchi, Momoko"

Thyrotoxic rubber antioxidants, 2-mercaptobenzimidazole and its methyl derivatives, cause both inhibition and induction of drug-metabolizing activity in rat liver microsomes after repeated oral administration by Miyajima, Atsuko, Sakemi-Hoshikawa, Kazue, Usami, Makoto, Mitsunaga, Katsuyoshi, Irie, Tomohiko, Ohno, Yasuo, Sunouchi, Momoko

“…We examined the effects of thyrotoxic rubber antioxidants, 2-mercaptobenzimidazole (MBI, 0.3 mmol/kg/day) and its methyl derivatives, methyl-MBIs [4-methyl-MBI…”
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Decreased Expression of Cytochromes P450 1A2, 2E1, and 3A4 and Drug Transporters Na+-Taurocholate-Cotransporting Polypeptide, Organic Cation Transporter 1, and Organic Anion-Transporting Peptide-C Correlates with the Progression of Liver Fibrosis in Chronic Hepatitis C Patients by NAKAI, Kenya, TANAKA, Hiromasa, KAMIKAWA, Yuichiro, KUBOTA, Keiichi, KITA, Junji, OZAWA, Shogo, OHNO, Yasuo, HANADA, Kazuhiko, OGATA, Hiroyasu, SUZUKI, Fumitaka, KUMADA, Hiromitsu, MIYAJIMA, Atsuko, ISHIDA, Seiichi, SUNOUCHI, Momoko, HABANO, Wataru

“…Patients with chronic hepatitis C viral infection underwent liver biopsies and laboratory studies for evaluation and to determine subsequent treatment. Changes…”
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Inhibitory and inductive effects of 4- or 5-methyl-2-mercaptobenzimidazole, thyrotoxic and hepatotoxic rubber antioxidants, on several forms of cytochrome P450 in primary cultured rat and human hepatocytes by Miyajima, Atsuko, Kuroda, Yukie, Sakemi-Hoshikawa, Kazue, Usami, Makoto, Mitsunaga, Katsuyoshi, Irie, Tomohiko, Ohno, Yasuo, Sunouchi, Momoko

“…•4-MeMBI, 5-MeMBI and MBI inhibit CYP3A2 activity in cultured rat hepatocytes.•4-MeMBI and 5-MeMBI, not MBI, induce CYP1A1/2 activity in cultured rat…”
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Proteomic analysis of indium embryotoxicity in cultured postimplantation rat embryos by Usami, Makoto, Nakajima, Mikio, Mitsunaga, Katsuyoshi, Miyajima, Atsuko, Sunouchi, Momoko, Doi, Osamu

“…Indium embryotoxicity was investigated by proteomic analysis with two-dimensional electrophoresis of rat embryos cultured from day 10.5 of gestation for 24 h…”
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Sexing of postimplantation rat embryos in stored two-dimensional electrophoresis (2-DE) samples by polymerase chain reaction (PCR) of an Sry sequence by Miyajima, Atsuko, Sunouchi, Momoko, Mitsunaga, Katsuyoshi, Yamakoshi, Yoko, Nakazawa, Ken, Usami, Makoto

“…Proteomic analysis of developmental toxicity by two-dimensional electrophoresis (2-DE) may detect gender-related toxic effects in embryos without visible…”
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Sexing of postimplantation rat embryos in stored twodimensional electrophoresis (2-DE) samples by polymerase chain reaction (PCR) of an Sry sequence by Miyajima, Atsuko, Sunouchi, Momoko, Mitsunaga, Katsuyoshi, Yamakoshi, Yoko, Nakazawa, Ken, Usami, Makoto

“…Proteomic analysis of developmental toxicity by two-dimensional electrophoresis (2-DE) may detect gender-related toxic effects in embryos without visible…”
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Chiral analyses of dextromethorphan/levomethorphan and their metabolites in rat and human samples using LC-MS/MS by Kikura-Hanajiri, Ruri, Kawamura, Maiko, Miyajima, Atsuko, Sunouchi, Momoko, Goda, Yukihiro

“…In order to develop an analytical method for the discrimination of dextromethorphan (an antitussive medicine) from its enantiomer, levomethorphan (a narcotic)…”
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Determination of a new designer drug, N -hydroxy-3,4-methylenedioxymethamphetamine and its metabolites in rats using ultra-performance liquid chromatography–tandem mass spectrometry by Kikura-Hanajiri, Ruri, Kawamura, Maiko, Miyajima, Atsuko, Sunouchi, Momoko, Goda, Yukihiro

“…Abstract An N -hydroxy analogue of 3,4-methylendioxymethamphetamine (MDMA), N -hydroxy MDMA ( N -OH MDMA), has recently been distributed as a new designer drug…”
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Complement component C3 functions as an embryotrophic factor in early postimplantation rat embryos by Usami, Makoto, Mitsunaga, Katsuyoshi, Miyajima, Atsuko, Sunouchi, Momoko, Doi, Osamu

“…A presumed embryotrophic factor for early postimplantation rat embryos, partially purified from rat serum, was identified as complement component C3 (C3), the…”
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Network for the collection and distribution of Japanese liver tissues resected surgically for drug development and research use by Sunouchi, Momoko, Sakemi, Kazue, Kubota, Kei-ichi, Kita, Junji, Kamikawa, Yuichiro, Uchida, Kohsuke, Miura, Shin-ichi, Shigehara, Eiji, Fujioka, Hiroyuki, Ohno, Yasuo

“…We focused on the establishment of a trial procedure for the collection and distribution of Japanese liver tissues obtained from waste surgical resections for…”
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Chiral analyses of dextromethorphan/levomethorphan and their metabolites in rat and human samples using LC-MS/MS : Forensic Toxicology by KIKURA-HANAJIRI, Ruri, KAWAMURA, Maiko, MIYAJIMA, Atsuko, SUNOUCHI, Momoko, GODA, Yukihiro

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Characterization of three forms of cytochrome P-450 inducible by 3-methylcholanthrene in Golden hamster livers with special reference to aflatoxin B1 activation by Fukuhara, M, Nohmi, T, Mizokami, K, Sunouchi, M, Ishidate, Jr, M, Takanaka, A

“…Three forms of cytochrome P-450 of liver microsomes of 3-methylcholanthrene-treated Golden hamsters were purified and characterized as regards their catalytic…”
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Indium inhibits gap junctional communication between rat hepatocytes in primary culture by Guo, X B, Ohno, Y, Kawanishi, T, Sunouchi, M, Takanaka, A

“…The effect of indium on gap junctional communication was investigated in primary cultured rat hepatocytes. Treatment of hepatocytes with indium chloride at…”
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EFFECTS OF VARIOUS INDUCERS ON THE ACTIVITIES OF CYTOCHROME P-450-MIXED FUNCTION OXIDASES AND AFLATOXIN B1 ACTIVATION IN MICROSOMES OF HAMSTER LIVERS by SUNOUCHI, Momoko, FUKUHARA, Morio, OHNO, Yasuo, TAKANAKA, Akira

“…The effects of various inducers on the activities of drug-metabolizing enzymes including aflatoxin B1 activation were studied in Syrian golden hamsters…”
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Cytotoxic effects of methylnitrosourea on developing brain by Fujimori, K, Sunouchi, M, Inoue, K, Nakadate, M, Takanaka, A, Omori, Y

“…The effect of methylnitrosourea (MNU) on cerebellar and cerebral DNA, RNA, protein, lysosomal enzymes (acid DNase, RNase, phosphatase, and beta-glucuronidase),…”
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Evidence for the participation of free radicals in the inhibition of gap junctional communication between hepatocytes by 25-hydroxycholesterol by Guo, Xinbiao, Ohno, Yasuo, Miyajima, Atsuko, Sunouchi, Momoko, Takanaka, Akira

“…We have previously shown that 25-hydroxycholesterol (25-OH), an oxidation product of cholesterol, inhibits gap junctional communication between rat hepatocytes…”
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Induction of Cytochrome P-450c and P-450d by Metyrapone in the Primary Culture of Rat Hepatocytes by HIROTA, Kouichi, KAWANISHI, Toru, SUNOUCHI, Momoko, OHNO, Yasuo, TAKANAKA, Akira, YAMAZOE, Yasushi, KATO, Ryuichi, MURAKOSHI, Yoshie

“…The effects of metyrapone on qualitative changes in cytochrome P-450-dependent drug metabolizing activities in primary cultures of rat hepatocytes were…”
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STUDIES ON NITROSAMINE FORMATION BY THE INTERACTION BETWEEN DRUGS AND NITRITE. II. : Hepatotoxicity by the simultaneous administration of several drugs and nitrite by KAWANISHI, Toru, OHNO, Yasuo, SUNOUCHI, Momoko, ONODA, Kin-ichi, TAKAHASHI, Atsushi, KASUYA, Yutaka, OMORI, Yoshihito

“…The alterations of biochemical parameters, namely, glutamic oxaloacetic transaminase and glutamic pyruvic transaminase in serum, hepatic microsomal drug…”
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Induction of Cytochrome P-450c and P-450d by Metyrapone in the Primary Culture of Rat Hepatocytes by HIROTA, Kouichi, KAWANISHI, Toru, SUNOUCHI, Momoko, OHNO, Yasuo, TAKANAKA, Akira, YAMAZOE, Yasushi, KATO, Ryuichi, MURAKOSHI, Yoshie

“…The effects of metyrapone on qualitative changes in cytochrome P-450-dependent drug metabolizing activities in primary cultures of rat hepatocytes were…”
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Studies on the Fate of Poisonous Metals in Experimental Animal (VII): Distribution and Transplacental Passage of Manganese in Pregnant Rat and Fetus by ONODA, Kin-ichi, HASEGAWA, Akira, SUNOUCHI, Momoko, TANAKA, Satoru, TAKANAKA, Akira, OMORI, Yoshihito, URAKUBO, Goro

“…Solutions of 54MnCl2 (0.5mg manganese chloride/kg, low dose; 10mg manganese chloride/kg, high dose) were intravenously injected to groups of pregnant rats on…”
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