Search Results - "Sunitha, Margaret S"

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations by Nag, Suman, Trivedi, Darshan V, Sarkar, Saswata S, Adhikari, Arjun S, Sunitha, Margaret S, Sutton, Shirley, Ruppel, Kathleen M, Spudich, James A

“…A working model for β-cardiac myosin in the sequestered state and binding assays reveal interactions between the myosin head and tail that are disrupted by…”
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Identification and stratification of systemic lupus erythematosus patients into two transcriptionally distinct clusters based on IFN-I signature by Shobha, Vineeta, Mohan, Anu, Malini, AV, Chopra, Puneet, Karunanithi, Preethi, Subramani Thulasingam, Siva, Selvam, Sabariya, Deyati, Avisek, Srivastava, Ratika, Basavanthappa, Sushma, Lemos, Nadine, Sunitha, S Margaret, Mazumder Tagore, Debarati, Anand, Amit, Pant, Saumya, Jayaswal, Vivek, Ramarao, Manjunath, Dudhgaonkar, Shailesh

“…Objective Despite the significant advancement in the understanding of the pathophysiology of systemic lupus erythematosus (SLE) variable clinical response to…”
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Dataset for the combined transcriptome assembly of M. oleifera and functional annotation by Shafi, K. Mohamed, Joshi, Adwait G., Meenakshi, Iyer, Pasha, Shaik Naseer, Harini, K., Mahita, Jarjapu, Sajeevan, Radha Sivarajan, Karpe, Snehal D., Ghosh, Pritha, Nitish, Sathyanarayanan, Gandhimathi, A., Mathew, Oommen K., Prasanna, Subramanian Hari, Malini, Manoharan, Mutt, Eshita, Naika, Mahantesha, Ravooru, Nithin, Rao, Rajas M., Shingate, Prashant N., Sukhwal, Anshul, Sunitha, Margaret S., Upadhyay, Atul K., Vinekar, Rithvik S., Sowdhamini, Ramanathan

“…In this paper, we present the data acquired during transcriptome analysis of the plant Moringa oleifera [1] from five different tissues (root, stem, leaf,…”
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A knowledge-driven protocol for prediction of proteins of interest with an emphasis on biosynthetic pathways by Joshi, Adwait G., Harini, K., Meenakshi, Iyer, Shafi, K. Mohamed, Pasha, Shaik Naseer, Mahita, Jarjapu, Sajeevan, Radha Sivarajan, Karpe, Snehal D., Ghosh, Pritha, Nitish, Sathyanarayanan, Gandhimathi, A., Mathew, Oommen K., Prasanna, Subramanian Hari, Malini, Manoharan, Mutt, Eshita, Naika, Mahantesha, Ravooru, Nithin, Rao, Rajas M., Shingate, Prashant N., Sukhwal, Anshul, Sunitha, Margaret S., Upadhyay, Atul K., Vinekar, Rithvik S., Sowdhamini, Ramanathan

“…This protocol describes a stepwise process to identify proteins of interest from a query proteome derived from NGS data. We implemented this protocol on…”
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Structural attributes for the recognition of weak and anomalous regions in coiled-coils of myosins and other motor proteins by Sunitha, Margaret S, Nair, Anu G, Charya, Amol, Jadhav, Kamalakar, Mukhopadhyay, Sami, Sowdhamini, Ramanathan

“…Coiled-coils are found in different proteins like transcription factors, myosin tail domain, tropomyosin, leucine zippers and kinesins. Analysis of various…”
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Integrative Structural Modelling of the Cardiac Thin Filament: Energetics at the Interface and Conservation Patterns Reveal a Spotlight on Period 2 of Tropomyosin by Margaret, Sunitha S, Mercer, John A., Spudich, James A., Sowdhamini, Ramanathan

“…Cardiomyopathies are a major health problem, with inherited cardiomyopathies, many of which are caused by mutations in genes encoding sarcomeric proteins,…”
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Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation by Homburger, Julian R., Green, Eric M., Caleshu, Colleen, Sunitha, Margaret S., Taylor, Rebecca E., Ruppel, Kathleen M., Metpally, Raghu Prasad Rao, Colan, Steven D., Michels, Michelle, Day, Sharlene M., Olivotto, Iacopo, Bustamante, Carlos D., Dewey, Frederick E., Ho, Carolyn Y., Spudich, James A., Ashley, Euan A.

“…Myosin motors are the fundamental force-generating elements of muscle contraction. Variation in the human β-cardiac myosin heavy chain gene (MYH7) can lead to…”
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Molecular mechanisms and structural features of cardiomyopathy-causing troponin T mutants in the tropomyosin overlap region by Gangadharan, Binnu, Sunitha, Margaret S., Mukherjee, Souhrid, Chowdhury, Ritu Roy, Haque, Farah, Sekar, Narendrakumar, Sowdhamini, Ramanathan, Spudich, James A., Mercer, John A.

“…Point mutations in genes encoding sarcomeric proteins are the leading cause of inherited primary cardiomyopathies. Among them are mutations in the TNNT2 gene…”
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Myosinome: A Database of Myosins from Select Eukaryotic Genomes to Facilitate Analysis of Sequence-Structure-Function Relationships by Syamaladevi, Divya P., Sunitha, Margaret S, Kalaimathy, S., Reddy, Chandrashekar C., Iftekhar, Mohammed, Pasha, Shaik N., Sowdhamini, R.

“…Myosins are one of the largest protein superfamilies with 24 classes. They have conserved structural features and catalytic domains yet show huge variation at…”
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The transcriptome enables the identification of candidate genes behind medicinal value of Drumstick tree (Moringa oleifera) by Pasha, Shaik Naseer, Shafi, K. Mohamed, Joshi, Adwait G., Meenakshi, Iyer, Harini, K., Mahita, Jarjapu, Sajeevan, Radha Sivarajan, Karpe, Snehal D., Ghosh, Pritha, Nitish, Sathyanarayanan, Gandhimathi, A., Mathew, Oommen K., Prasanna, Subramanian Hari, Malini, Manoharan, Mutt, Eshita, Naika, Mahantesha, Ravooru, Nithin, Rao, Rajas M., Shingate, Prashant N., Sukhwal, Anshul, Sunitha, Margaret S., Upadhyay, Atul K., Vinekar, Rithvik S., Sowdhamini, Ramanathan

“…Moringa oleifera is a plant well-known for its nutrition value, drought resistance and medicinal properties. cDNA libraries from five different tissues (leaf,…”
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Genome sequencing of herb Tulsi (Ocimum tenuiflorum) unravels key genes behind its strong medicinal properties by Upadhyay, Atul K, Chacko, Anita R, Gandhimathi, A, Ghosh, Pritha, Harini, K, Joseph, Agnel P, Joshi, Adwait G, Karpe, Snehal D, Kaushik, Swati, Kuravadi, Nagesh, Lingu, Chandana S, Mahita, J, Malarini, Ramya, Malhotra, Sony, Malini, Manoharan, Mathew, Oommen K, Mutt, Eshita, Naika, Mahantesha, Nitish, Sathyanarayanan, Pasha, Shaik Naseer, Raghavender, Upadhyayula S, Rajamani, Anantharamanan, Shilpa, S, Shingate, Prashant N, Singh, Heikham Russiachand, Sukhwal, Anshul, Sunitha, Margaret S, Sumathi, Manojkumar, Ramaswamy, S, Gowda, Malali, Sowdhamini, Ramanathan

“…Krishna Tulsi, a member of Lamiaceae family, is a herb well known for its spiritual, religious and medicinal importance in India. The common name of this plant…”
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Mechanistic Heterogeneity in Contractile Properties of α-Tropomyosin (TPM1) Mutants Associated with Inherited Cardiomyopathies by Gupte, Tejas M., Haque, Farah, Gangadharan, Binnu, Sunitha, Margaret S., Mukherjee, Souhrid, Anandhan, Swetha, Rani, Deepa Selvi, Mukundan, Namita, Jambekar, Amruta, Thangaraj, Kumarasamy, Sowdhamini, Ramanathan, Sommese, Ruth F., Nag, Suman, Spudich, James A., Mercer, John A.

“…The most frequent known causes of primary cardiomyopathies are mutations in the genes encoding sarcomeric proteins. Among those are 30 single-residue mutations…”
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Molecular Mechanisms of Cardiomyopathy-Causing TnT Mutants Implicated in Interactions with Tropomyosin by Gangadharan, Binnu, Mukherjee, Souhrid, Sunitha, Margaret S., Dubey, Ashvini, Sowdhamini, R., Spudich, James A., Mercer, John A.

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Multidimensional structure-function relationships in human [Beta]-cardiac myosin from population-scale genetic variation by Homburger, Julian R, Green, Eric M, Caleshu, Colleen, Sunitha, Margaret S, Taylor, Rebecca E, Ruppel, Kathleen M, Metpally, Raghu Prasad Rao, Colan, Steven D, Michels, Michelle, Day, Sharlene M, Olivotto, Iacopo, Bustamante, Carlos D, Dewey, Frederick E, Ho, Carolyn Y, Spudich, James A, Ashley, Euan A

“…Myosin motors are the fundamental force-generating elements of muscle contraction. Variation in the human β-cardiac myosin heavy chain gene (MYH7) can lead to…”
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Myosinome: A Database of Myosins from elect ukaryotic Genomes to Facilitate Analysis of equence- tructure- Function Relationships by Divya P. Syamaladevi, Margaret S Sunitha, S. Kalaimathy, chandrashekar C. reddy, Mohammed Iftekhar, Shaik N. Pasha, R. Sowdhamini

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Myosinome: A Database of Myosins from Select Eukaryotic Genomes to Facilitate Analysis of Sequence-Structure-Function Relationships by Divya P. Syamaladevi, Margaret Sunitha S, S. Kalaimathy, Chandrashekar C. Reddy, Mohammed Iftekhar, Shaik N. Pasha, R. Sowdhamini

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Integrative Structural Modelling of the Cardiac Thin Filament: Energetics at the Interface and Conservation Patterns Reveal a Spotlight on Period 2 of Tropomyosin by Sunitha S Margaret, John A. Mercer, James A. Spudich, Ramanathan Sowdhamini

“…Cardiomyopathies are a major health problem, with inherited cardiomyopathies, many of which are caused by mutations in genes encoding sarcomeric proteins,…”
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