Search Results - "Sunil KC"

The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models by Tam, Betty Y., Chiu, Kevin, Chung, Heekyung, Bossard, Carine, Nguyen, John Duc, Creger, Emily, Eastman, Brian W., Mak, Chi Ching, Ibanez, Maureen, Ghias, Abdullah, Cahiwat, Joseph, Do, Long, Cho, Shawn, Nguyen, Jackie, Deshmukh, Vishal, Stewart, Josh, Chen, Chiao-Wen, Barroga, Charlene, Dellamary, Luis, KC, Sunil K., Phalen, Timothy J., Hood, John, Cha, Steven, Yazici, Yusuf

“…The Wnt/β-catenin signaling pathway is aberrantly activated in colorectal (CRC) and many other cancers, and novel strategies for effectively targeting it may…”
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Synthesis of a novel glucose capped gold nanoparticle as a better theranostic candidate by Suvarna, Saritha, Das, Ujjal, Kc, Sunil, Mishra, Snehasis, Sudarshan, Mathummal, Saha, Krishna Das, Dey, Sanjit, Chakraborty, Anindita, Narayana, Y

“…Gold nanoparticles are predominantly used in diagnostics, therapeutics and biomedical applications. The present study has been designed to synthesize…”
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SM04755, a small‐molecule inhibitor of the Wnt pathway, as a potential topical treatment for tendinopathy by Deshmukh, Vishal, Seo, Tim, O'Green, Alyssa L., Ibanez, Maureen, Hofilena, Brian, KC, Sunil, Stewart, Joshua, Dellamary, Luis, Chiu, Kevin, Ghias, Abdullah, Barroga, Charlene, Kennedy, Sarah, Tambiah, Jeyanesh, Hood, John, Yazici, Yusuf

“…The Wnt pathway is upregulated in tendinopathy, affecting inflammation and tenocyte differentiation. Given its potential role in tendinopathy, this signaling…”
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Clinico-Epidemiological Profile of Patients with COVID-19 in a Tertiary Care Centre of Mid-Western Nepal by Karki, Shravya Singh, Basnet, Pragya S, Karki, Sauharda S, Lamichhane, Basant, Sharma, Damodar, Acharya, Birendra K, KC, Sunil, Seikh, Salman, Kunwar, Santosh, Rajbhandari, Nishtha, Bhandari, Ujjwal MS, Panthi, Sagar, Karki, Angelica, Lamichhane, Jhankar, Bhandary, Sangita

“…Introduction: With little to no research done that sheds light on the COVID-19 pandemic in the Mid-Western region of Nepal, this study attempts to educate the…”
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Medicinal plants from Nepal; II. Evaluation as inhibitors of lipid peroxidation in biological membranes by Kumar KC, Sunil, Müller, Klaus

“…In an ethnopharmacological screening of selected Nepalese medicinal plants, the inhibitory effect on lipid peroxidation of 36 methanolic extracts of 28…”
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Depsides as non-redox inhibitors of leukotriene B4 biosynthesis and HaCaT cell growth. 1. Novel analogues of barbatic and diffractaic acid by Kumar KC, Sunil, Müller, Klaus

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Depsides as non-redox inhibitors of leukotriene B4 biosynthesis and HaCaT cell growth, 2. Novel analogues of obtusatic acid by Kumar KC, S

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One pot synthesis of CuO-NiO nanoparticles using Aegle marmelos fruit extract and their antimicrobial activity by Kudlur, Deeksha S., Meghashree, AM, Vinutha, SA, Sunil Kumar, KC, Karthik, G., Venkatesh, PA, Lakshmi Ranganatha, V., Nagaraju, G., Mallikarjunaswamy, C.

“…In this study, bimetallic Copper oxide and nickel oxide nanoparticles (CuO-NiO NPs) were synthesized using a green approach that utilized Aegle marmelos fruit…”
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The Response of Serum Cortisol and Leptin Levels to Academic Stress by Elizabeth J, Dayananda G, Kusumadevi MS, Sunil KC, Sujayasri S, Suhas S

“…Background: Medical students are subjected to various types of stress during the academic course and they react differently. This study is an attempt to…”
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Abstract C08: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates activity against cancer stem cell (CSC)-enriched pancreatic cancer cells and suppresses stemness in vitro by Bossard, Carine, Cruz, Nathalia, Eastman, Brian, Mak, Chi-Ching, KC, Sunil, Tam, Betty, Phalen, Timothy, Cha, Steven

“…Abstract Cancer stem cells (CSCs) are a rare subpopulation of quiescent tumor cells with the ability to self-renew and form new tumors (stemness) that have…”
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Abstract 6401: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates strong antitumor effects and Wnt and cyclin D-CDK4/6-RB pathway inhibition in hormone-receptor-positive (HR+) breast cancer models by Chung, Heekyung, Sitts, Lauren, Wu, Chu-Chiao, Eastman, Brian, Mak, Chi Ching, KC, Sunil, Stewart, Josh, Bossard, Carine, Phalen, Timothy J., Cha, Steven

“…Abstract Dysregulation of the cyclin D-CDK4/6-RB signaling axis is implicated in HR+ breast cancer (BC). While CDK4/6 inhibitors such as palbociclib (Palbo)…”
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Abstract 5691: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates strong antitumor effects and Wnt pathway inhibition in castration-resistant prostate cancer (CRPC) models by Bossard, Carine, Cruz, Nathalia, Chiu, Kevin, Eastman, Brian, Mak, Chi Ching, KC, Sunil, Bucci, Gail, Stewart, Josh, Phalen, Timothy J., Cha, Steven

“…Abstract CRPC is associated with primary and acquired chemotherapy resistance. Loss of androgen receptor (AR) signaling or development of AR splicing variants…”
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Abstract P3-13-01: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates strong inhibition of the Wnt signaling pathway and antitumor effects as monotherapy and in combination with chemotherapy in triple-negative breast cancer (TNBC) models by Chung, Heekyung, Sitts, Lauren, Creger, Emily, Nguyen, John Duc, Eastman, Brian, Mak, Chi-Ching, KC, Sunil, Tam, Betty, Bossard, Carine, Phalen, Timothy, Cha, Steven

“…Abstract Aberrant activation of the Wnt signaling pathway is associated with tumorigenesis, relapse/chemoresistance, and distance metastasis in TNBC. SM08502…”
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SM09419, a Novel, Small-Molecule CDC-like Kinase (CLK) Inhibitor, Demonstrates Strong Inhibition of the Wnt Signaling Pathway and Antitumor Effects in Tumor Protein p53 (TP53)-Mutant Acute Myeloid Leukemia Models by Chung, Heekyung, Creger, Emily, Sitts, Lauren, Chiu, Kevin, Mak, Chi-Ching, KC, Sunil, Tam, Betty, Bucci, Gail, Stewart, Josh, Phalen, Timothy, Cha, Steven

“…Acute myeloid leukemia (AML) with TP53 mutation makes up ~13% of AML cases and is an aggressive, treatment-resistant subtype with dismal prognosis and limited…”
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SM09419, a Novel, Small-Molecule CDC-like Kinase (CLK) Inhibitor, Demonstrates Strong Inhibition of the Wnt Signaling Pathway and Antitumor Effects in FMS-like Tyrosine Kinase 3 (FLT3)-Mutant Acute Myeloid Leukemia Models by Chung, Heekyung, Creger, Emily, Sitts, Lauren, Chiu, Kevin, Mak, Chi-Ching, KC, Sunil, Tam, Betty, Bucci, Gail, Stewart, Josh, Phalen, Timothy, Cha, Steven

“…Acute myeloid leukemia (AML) with the FLT3 internal tandem duplication (FLT3-ITD) mutation accounts for ~25% of all AMLs, carries a poor prognosis, and is…”
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SM09419, a Novel, Small-Molecule CDC-like Kinase (CLK) Inhibitor, Demonstrates Strong Inhibition of the Wnt Signaling Pathway and Antitumor Effects in Mantle Cell Lymphoma Models by Chung, Heekyung, Creger, Emily, Sitts, Lauren, Chiu, Kevin, Mak, Chi-Ching, KC, Sunil, Tam, Betty, Bucci, Gail, Stewart, Josh, Phalen, Timothy, Cha, Steven

“…Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma (NHL) that accounts for ~7% of all NHL in the U.S. MCL is associated with aberrant activation of…”
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β-Carbolinedione Derivatives as Topoisomerase I Inhibitors by Mahboobi, Siavosh, Eluwa, Stella, Kumar KC, Sunil, Koller, Markus, Störl, Karin

“…Pyrrolo[3,4‐c]‐β‐carbolinedione dimers 5—14 were synthesized from furo[3,4‐c]‐β‐carbolinediones and diamines by solvent‐free TaCl5/silica catalyzed reaction…”
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Effects of SM08502, a novel, oral small-molecule inhibitor of Wnt pathway signaling, on gene expression and antitumor activity in colorectal cancer (CRC) models by Bossard, Carine, Chiu, Kevin, Chung, Heekyung, Nguyen, John Duc, Creger, Emily, Eastman, Brian, Mak, Chi Ching, Do, Long, Cho, Shawn, KC, Sunil, Phalen, Timothy, Tambiah, Jeyanesh, Cha, Steven

“…Abstract only e15185 Background: Aberrant activation of Wnt signaling contributing to tumorigenesis is most commonly associated with CRC (90% harbor Wnt…”
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TAU PATHOLOGY REDUCTION WITH SM07883, A NOVEL, POTENT, AND SELECTIVE ORAL DYRK1A INHIBITOR: A POTENTIAL THERAPEUTIC FOR ALZHEIMER’S DISEASE by Melchior, Ben, Lai, Carolyn, Duong-Polk, Karen, Tjitro, Amanda, Ince, Deniz C., Stewart, Joshua, Dellamary, Luis, Hofilena, Brian, Mittapalli, Gopi, KC, Sunil, Yazici, Yusuf

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O4‐05‐03: TAU PATHOLOGY REDUCTION WITH SM07883, A NOVEL, POTENT, AND SELECTIVE ORAL DYRK1A INHIBITOR: A POTENTIAL THERAPEUTIC FOR ALZHEIMER'S DISEASE by Melchior, Ben, Lai, Carolyn, Duong-Polk, Karen, Tjitro, Amanda, Ince, Deniz C., Stewart, Joshua, Dellamary, Luis, Hofilena, Brian, Mittapalli, Gopi, KC, Sunil, Yazici, Yusuf

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