Search Results - "Sung, Kisu"

Design, Synthesis, and Molecular Docking Analysis of Fluorinated MLN4924 Derivatives as Antiviral Agents by Sung, Kisu, Hyeon, Seokhwan, Kim, Minjae, Sahu, Pramod K., Naik, Siddhi D., Aswar, Vikas R., Tripathi, Sushil K., Chang, Tong‐Shin, Ahn, Jin‐Hyun, Yu, Jinha, Jeong, Lak Shin

“…MLN4924 is known for its potential in cancer treatment and antiviral activity as a NEDD8‐activating enzyme (NAE) inhibitor. We designed and synthesized…”
Get full text

Development of 4′-Oxo-MLN4924 as potential neddylation inhibitors: Design, synthesis, anti-HCMV evaluation, and molecular docking by Sung, Kisu, Oh, Sehwan, Kim, Hong-Rae, Hyeon, Seokhwan, Ahn, Jin-Hyun, Kim, Suyeon, Aswar, Vikas R., Tripathi, Sushil K., Yu, Jinha, Shin Jeong, Lak

“…[Display omitted] •Designed and synthesized 4′-oxo-MLN4924 derivatives.•The 4′-oxo-MLN4924 derivative containing a 2′-hydroxyl group showed potent activity…”
Get full text

Discovery of a Novel Template, 7-Substituted 7-Deaza-4'-Thioadenosine Derivatives as Multi-Kinase Inhibitors by Mashelkar, Karishma K, Byun, Woong Sub, Ko, Hyejin, Sung, Kisu, Tripathi, Sushil K, An, Seungchan, Yum, Yun A, Kwon, Jee Youn, Kim, Minjae, Kim, Gibae, Kwon, Eun-Ji, Lee, Hyuk Woo, Noh, Minsoo, Lee, Sang Kook, Jeong, Lak Shin

“…The development of anticancer drugs remains challenging owing to the potential for drug resistance. The simultaneous inhibition of multiple targets involved in…”
Get full text

In Silico Discovery of 5′-Modified 7‑Deoxy-7-ethynyl-4′-thioadenosine as a HASPIN Inhibitor and Its Synergistic Anticancer Effect with the PLK1 Inhibitor by Kwon, Eun-Ji, Mashelkar, Karishma K., Seo, Juhee, Shin, Yoon-Ze, Sung, Kisu, Jang, Sung Chul, Cheon, Sang Won, Lee, Haeseung, Lee, Hyuk Woo, Kim, Gyudong, Han, Byung Woo, Lee, Sang Kook, Jeong, Lak Shin, Cha, Hyuk-Jin

“…Despite genetic perturbations resulting in embryo lethality for most mitotic kinases, loss of the histone H3 mitotic kinase HASPIN reveals no adverse effect in…”
Get full text

Asymmetric Synthesis of Fluoro‐MLN4924 as a Selective NEDD8‐Activating Enzyme (NAE) Inhibitor by Kim, Hong‐Rae, Jarhad, Dnyandev B., Sahu, Pramod K., Sung, Kisu, An, Dayoung, Hyun, Young Eum, Yu, Jinha, Jeong, Lak Shin

“…Based on bioisosteric rationale, fluorinated analogues of MLN4924, which is a selective NEDD8‐activating enzyme inhibitor, were designed and their asymmetric…”
Get full text

Stereoselective Approach for the Synthesis of Diverse 1′-Modified Carbanucleosides by Sung, Kisu, Aswar, Vikas R., Song, Jiyoon, Jarhad, Dnyandev B., Jeong, Lak Shin

“…We describe an efficient and stereoselective synthesis of 1'-substituted-β-carbocylic nucleosides 5 via gem-dichlorooxirane intermediate 7, which directly…”
Get full text