Search Results - "Sung, Joseph J."

Multi-cohort analysis of colorectal cancer metagenome identified altered bacteria across populations and universal bacterial markers by Dai, Zhenwei, Coker, Olabisi Oluwabukola, Nakatsu, Geicho, Wu, William K K, Zhao, Liuyang, Chen, Zigui, Chan, Francis K L, Kristiansen, Karsten, Sung, Joseph J Y, Wong, Sunny Hei, Yu, Jun

“…Alterations of gut microbiota are associated with colorectal cancer (CRC) in different populations and several bacterial species were found to contribute to…”
Get full text

CRISPR screens identify cholesterol biosynthesis as a therapeutic target on stemness and drug resistance of colon cancer by Gao, Shanshan, Soares, Fraser, Wang, Shiyan, Wong, Chi Chun, Chen, Huarong, Yang, Zhenjie, Liu, Weixin, Go, Minnie Y. Y., Ahmed, Musaddeque, Zeng, Yong, O’Brien, Catherine Adell, Sung, Joseph J. Y., He, Housheng Hansen, Yu, Jun

“…Cancer stem cells (CSCs) are responsible for tumor progression, recurrence, and drug resistance. To identify genetic vulnerabilities of colon cancer, we…”
Get full text

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies by Ng, Siew C, Shi, Hai Yun, Hamidi, Nima, Underwood, Fox E, Tang, Whitney, Benchimol, Eric I, Panaccione, Remo, Ghosh, Subrata, Wu, Justin C Y, Chan, Francis K L, Sung, Joseph J Y, Kaplan, Gilaad G

“…Inflammatory bowel disease is a global disease in the 21st century. We aimed to assess the changing incidence and prevalence of inflammatory bowel disease…”
Get full text

TGF-β/Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29 by WEI QIN, CHUNG, Arthur C. K, HUANG, Xiao R, MENG, Xiao-Ming, HUI, David S. C, YU, Cheuk-Man, SUNG, Joseph J. Y, LAN, Hui Y

“…TGF-β/Smad3 signaling promotes fibrosis, but the development of therapeutic interventions involving this pathway will require the identification and ultimate…”
Get full text

Mucosal microbiome dysbiosis in gastric carcinogenesis by Coker, Olabisi Oluwabukola, Dai, Zhenwei, Nie, Yongzhan, Zhao, Guijun, Cao, Lei, Nakatsu, Geicho, Wu, William Kk, Wong, Sunny Hei, Chen, Zigui, Sung, Joseph J Y, Yu, Jun

“…We aimed to characterise the microbial changes associated with histological stages of gastric tumourigenesis. We performed 16S rRNA gene analysis of gastric…”
Get more information

Viral Loads and Duration of Viral Shedding in Adult Patients Hospitalized with Influenza by Lee, Nelson, Chan, Paul K. S., Hui, David S. C., Rainer, Timothy H., Wong, Eric, Choi, Kin-Wing, Lui, Grace C. Y., Wong, Bonnie C. K., Wong, Rita Y. K., Lam, Wai-Yip, Chu, Ida M. T., Lai, Raymond W. M., Cockram, Clive S., Sung, Joseph J. Y.

“…BackgroundThe goal of this study was to characterize viral loads and factors affecting viral clearance in persons with severe influenza MethodsThis was a…”
Get full text

Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer by Tsang, Wing Pui, Ng, Enders K.O., Ng, Simon S.M., Jin, Hongchuan, Yu, Jun, Sung, Joseph J.Y., Kwok, Tim Tak

“…H19 is an imprinted oncofetal non-coding RNA recently shown to be the precursor of miR-675. The pathophysiological roles of H19 and its mature product miR-675…”
Get full text

Detection of miR-92a and miR-21 in stool samples as potential screening biomarkers for colorectal cancer and polyps by Wu, Chung Wah, Ng, Simon S M, Dong, Yu Juan, Ng, Siew Chien, Leung, Wing Wa, Lee, Chung Wa, Wong, Yee Ni, Chan, Francis K L, Yu, Jun, Sung, Joseph J Y

“…The detection of molecular markers in stool samples is a potential strategy for colorectal cancer (CRC) screening. This study evaluated the feasibility of…”
Get more information

Genome‐wide identification of Epstein‐Barr virus–driven promoter methylation profiles of human genes in gastric cancer cells by Zhao, Junhong, Liang, Qiaoyi, Cheung, Kin‐Fai, Kang, Wei, Lung, Raymond W. M., Tong, Joanna H. M., To, Ka Fai, Sung, Joseph J. Y., Yu, Jun

“…BACKGROUND: Aberrant methylation of tumor‐related genes has been reported in Epstein‐Barr virus (EBV)‐associated gastric cancers. This study sought to profile…”
Get full text

Opening the black box of AI‐Medicine by Poon, Aaron I F, Sung, Joseph J Y

“…One of the biggest challenges of utilizing artificial intelligence (AI) in medicine is that physicians are reluctant to trust and adopt something that they do…”
Get full text

Peptostreptococcus anaerobius Induces Intracellular Cholesterol Biosynthesis in Colon Cells to Induce Proliferation and Causes Dysplasia in Mice by Tsoi, Ho, Chu, Eagle SH, Zhang, Xiang, Sheng, Jianqiu, Nakatsu, Daniel, Ng, Siew C, Chan, Anthony WH, Chan, Francis KL, Sung, Joseph JY, Yu, Jun

“…Abstract Background & Aims Stool samples from patients with colorectal cancer (CRC) have a higher abundance of Peptostreptococcus anaerobius than stool from…”
Get full text

Screening for gastric cancer in Asia: current evidence and practice by Leung, Wai K, Dr, Wu, Ming-shiang, MD, Kakugawa, Yasuo, MD, Kim, Jae J, MD, Yeoh, Khay-guan, MBBS, Goh, Khean Lee, Prof, Wu, Kai-chun, Prof, Wu, Deng-chyang, Prof, Sollano, Jose, MD, Kachintorn, Udom, MD, Gotoda, Takuji, MD, Lin, Jaw-town, Prof, You, Wei-cheng, Prof, Ng, Enders KW, MD, Sung, Joseph JY, Prof

“…Summary Gastric cancer is the second most common cause of death from cancer in Asia. Although surgery is the standard treatment for this disease, early…”
Get full text

Defective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitis by Wang, Xiaojuan, Zhang, Xiang, Chu, Eagle S. H., Chen, Xiaoting, Kang, Wei, Wu, Feng, To, Ka‐Fai, Wong, Vincent W. S., Chan, Henry L. Y., Chan, Matthew T. V., Sung, Joseph J. Y., Wu, William K. K., Yu, Jun

“…Autophagic impairment is implicated in nonalcoholic fatty liver disease (NAFLD), but the molecular mechanism is unclear. We found that autophagic flux was…”
Get full text

Gut mucosal microbiome across stages of colorectal carcinogenesis by Nakatsu, Geicho, Li, Xiangchun, Zhou, Haokui, Sheng, Jianqiu, Wong, Sunny Hei, Wu, William Ka Kai, Ng, Siew Chien, Tsoi, Ho, Dong, Yujuan, Zhang, Ning, He, Yuqi, Kang, Qian, Cao, Lei, Wang, Kunning, Zhang, Jingwan, Liang, Qiaoyi, Yu, Jun, Sung, Joseph J. Y.

“…Gut microbial dysbiosis contributes to the development of colorectal cancer (CRC). Here we catalogue the microbial communities in human gut mucosae at…”
Get full text

Gut mucosal virome alterations in ulcerative colitis by Zuo, Tao, Lu, Xiao-Juan, Zhang, Yu, Cheung, Chun Pan, Lam, Siu, Zhang, Fen, Tang, Whitney, Ching, Jessica Y L, Zhao, Risheng, Chan, Paul K S, Sung, Joseph J Y, Yu, Jun, Chan, Francis K L, Cao, Qian, Sheng, Jian-Qiu, Ng, Siew C

“…The pathogenesis of UC relates to gut microbiota dysbiosis. We postulate that alterations in the viral community populating the intestinal mucosa play an…”
Get more information

Yes-Associated Protein 1 Exhibits Oncogenic Property in Gastric Cancer and Its Nuclear Accumulation Associates with Poor Prognosis by WEI KANG, TONG, Joanna H. M, SUNG, Joseph J. Y, TO, Ka-Fai, CHAN, Anthony W. H, LEE, Tin-Lap, LUNG, Raymond W. M, LEUNG, Patrick P. S, SO, Ken K. Y, KAICHUN WU, DAIMING FAN, JUN YU

“…Yes-associated protein 1 (YAP1) is a multifunctional protein that can interact with different transcription factors to activate gene expression. The role of…”
Get full text

Continuation of Low-Dose Aspirin Therapy in Peptic Ulcer Bleeding: A Randomized Trial by SUNG, Joseph J. Y, LAU, James Y. W, CHING, Jessica Y. L, WU, Justin C. Y, LEE, Yuk T, CHIU, Philip W. Y, LEUNG, Vincent K. S, WONG, Vincent W. S, CHAN, Francis K. L

“…It is uncertain whether aspirin therapy should be continued after endoscopic hemostatic therapy in patients who develop peptic ulcer bleeding while receiving…”
Get full text

FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells by Ren, Shun X, Shen, Jin, Cheng, Alfred S L, Lu, Lan, Chan, Ruby L Y, Li, Zhi J, Wang, Xiao J, Wong, Clover C M, Zhang, Lin, Ng, Simon S M, Chan, Franky L, Chan, Francis K L, Yu, Jun, Sung, Joseph J Y, Wu, William K K, Cho, Chi H

“…Host immune peptides, including cathelicidins, have been reported to possess anticancer properties. We previously reported that LL-37, the only cathelicidin in…”
Get full text

Altered gut metabolites and microbiota interactions are implicated in colorectal carcinogenesis and can be non-invasive diagnostic biomarkers by Coker, Olabisi Oluwabukola, Liu, Changan, Wu, William Ka Kei, Wong, Sunny Hei, Jia, Wei, Sung, Joseph J Y, Yu, Jun

“…Gut microbiota contributes to colorectal cancer (CRC) pathogenesis through microbes and their metabolites. The importance of microbiota-associated metabolites…”
Get full text

Overview of guidance for endoscopy during the coronavirus disease 2019 pandemic by Lui, Rashid N, Wong, Sunny H, Sánchez‐Luna, Sergio A, Pellino, Gianluca, Bollipo, Steven, Wong, Mei‐Yin, Chiu, Philip W Y, Sung, Joseph J Y

“…From its beginning in December 2019, the coronavirus disease 2019 outbreak has spread globally from Wuhan and is now declared a pandemic by the World Health…”
Get full text