Search Results - "Sung, Hee Um"

Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance by Tremblay, Frédéric, Brûlé, Sophie, Hee Um, Sung, Li, Yu, Masuda, Kohei, Roden, Michael, Sun, Xiao Jian, Krebs, Michael, Polakiewicz, Roberto D, Thomas, George, Marette, André

“…S6K1 has emerged as a critical signaling component in the development of insulin resistance through phosphorylation and inhibition of IRS-1 function. This…”
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CD10 expression is enhanced by Twist1 and associated with poor prognosis in esophageal squamous cell carcinoma with facilitating tumorigenicity in vitro and in vivo by Lee, Keun‐Woo, Sung, Chang Ohk, Kim, Jeong Hoon, Kang, Myungsoo, Yoo, Hae‐Yong, Kim, Hyeon‐Ho, Um, Sung‐Hee, Kim, Seok‐Hyung

“…CD10 expression was identified as a contributor to cancer progression in several cancers; however, the exact biological significance and mechanism of CD10…”
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Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development by Gangloff, Yann-Gaël, Mueller, Matthias, Dann, Stephen G., Svoboda, Petr, Sticker, Melanie, Spetz, Jean-Francois, Um, Sung Hee, Brown, Eric J., Cereghini, Silvia, Thomas, George, Kozma, Sara C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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S6 kinase 2 deficiency enhances ketone body production and increases peroxisome proliferator-activated receptor alpha activity in the liver by Kim, KyeongJin, Pyo, Suhkneung, Um, Sung Hee

“…Nutrient homeostasis is tightly regulated by the balance between energy production and utilization. During fasting, production of ketone bodies as an…”
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Site‐Selective Rhodium(III)‐Catalyzed C−H Amination of 7‐Azaindoles with Anthranils: Synthesis and Anticancer Evaluation by Jeon, Mijin, Park, Jihye, Dey, Prasanta, Oh, Yongguk, Oh, Hyunjung, Han, Sangil, Um, Sung Hee, Kim, Hyung Sik, Mishra, Neeraj Kumar, Kim, In Su

“…The site‐selective C−H amination reaction of 7‐azaindoles with various benzisoxazoles as amination surrogates under cationic rhodium(III) catalysis is…”
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S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis by Yi, Sang Ah, Um, Sung Hee, Lee, Jaecheol, Yoo, Ji Hee, Bang, So Young, Park, Eun Kyung, Lee, Min Gyu, Nam, Ki Hong, Jeon, Ye Ji, Park, Jong Woo, You, Jueng Soo, Lee, Sang-Jin, Bae, Gyu-Un, Rhie, Jong Won, Kozma, Sara C., Thomas, George, Han, Jeung-Whan

“…S6K1 has been implicated in a number of key metabolic responses, which contribute to obesity. Critical among these is the control of a transcriptional program…”
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S6K1 Plays a Critical Role in Early Adipocyte Differentiation by Carnevalli, Larissa S., Masuda, Kouhei, Frigerio, Francesca, Le Bacquer, Olivier, Um, Sung Hee, Gandin, Valentina, Topisirovic, Ivan, Sonenberg, Nahum, Thomas, George, Kozma, Sara C.

“…Earlier, we reported that S6K1 −/− mice have reduced body fat mass, have elevated rates of lipolysis, have severely decreased adipocyte size, and are resistant…”
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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. [Erratum: 2004 Sept. 23, v. 431, no. 7007, p. 485.] by Um, S.H, Frigerio, F, Watanabe, M, Picard, F, Joaquin, M, Sticker, M, Fumagalli, S, Allegrini, P.R, Kozma, S.C, Auwerx, J

“…Elucidating the signalling mechanisms by which obesity leads to impaired insulin action is critical in the development of therapeutic strategies for the…”
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Anti-Adipogenic Effects of Salicortin from the Twigs of Weeping Willow (Salix pseudolasiogyne) in 3T3-L1 Cells by Kim, Hee Jung, Lee, Da Eun, Park, Eon Chung, Ra, Moon-Jin, Jung, Sang-Mi, Yu, Jeong-Nam, Um, Sung Hee, Kim, Ki Hyun

“…Salix pseudolasiogyne (Salicaceae), the “weeping willow,” has been used in traditional Korean medicine to treat pain and fever due to its high concentrations…”
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S6K1−/−/S6K2−/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway by Pende, Mario, Um, Sung Hee, Mieulet, Virginie, Sticker, Melanie, Goss, Valerie L., Mestan, Jurgen, Mueller, Matthias, Fumagalli, Stefano, Kozma, Sara C., Thomas, George

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Bioactive Phytochemicals from Salix pseudolasiogyne Twigs: Anti-Adipogenic Effect of 2′-O-Acetylsalicortin in 3T3-L1 Cells by Kim, Hee Jung, Jang, Yoon Seo, Ha, Ji Won, Ra, Moon-Jin, Jung, Sang-Mi, Yu, Jeong-Nam, Kim, Kyunga, Kim, Ki Hyun, Um, Sung Hee

“…Salix pseudolasiogyne (Salicaceae) is a willow tree and has been used as a medicinal herb in Korea to treat pain and fever. As a part of an ongoing study to…”
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Carbamazepine Enhances Adipogenesis by Inhibiting Wnt/β-catenin Expression by Im, Dong Uk, Kim, Sang Chon, Chau, Gia Cac, Um, Sung Hee

“…Carbamazepine is a drug that is widely used in the treatment of epilepsy and bipolar disorder. The prevalence of obesity in patients treated with carbamazepine…”
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The Novel Inhibitory Effect of YM976 on Adipocyte Differentiation by Kim, Hee Jung, Kim, Dong-Hoon, Um, Sung Hee

“…The pyrimidine derivative YM976 (4-(3-chlorophenyl)-1,7-diethylpyrido(2,3- )-pyrimidin-2(1 )-one) exerts anti-inflammatory and anti-asthmatic effects…”
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A Fermented Ginseng Extract, BST204, Inhibits Proliferation and Motility of Human Colon Cancer Cells by Park, Jong-Woo, Lee, Jae-Cheol, Ann, So-Ra, Seo, Dong-Wan, Choi, Wahn-Soo, Yoo, Young-Hyo, Park, Sun-Kyu, Choi, Jung-Young, Um, Sung-Hee, Ahn, Seong-Hoon, Han, Jeung-Whan

“…Panax ginseng CA Meyer, a herb from the Araliaceae, has traditionally been used as a medicinal plant in Asian countries. Ginseng extract fermented by…”
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Diosgenin inhibits macrophage-derived inflammatory mediators through downregulation of CK2, JNK, NF-κB and AP-1 activation by Jung, Da-Hye, Park, Hye-Jin, Byun, Hye-Eun, Park, Yoon-Moon, Kim, Tae-Wan, Kim, Byung-Oh, Um, Sung-Hee, Pyo, Suhkneung

“…Diosgenin is a precursor of steroid hormones, which can be found in several plant species. Diosgenin has been shown to have a variety of biological activities…”
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Exosome-Mediated Differentiation of Mouse Embryonic Fibroblasts and Exocrine Cells into β-Like Cells and the Identification of Key miRNAs for Differentiation by Mandal, Paulami, De, Debojyoti, Im, Dong Uk, Um, Sung Hee, Kim, Kyeong Kyu

“…Diabetes is a concerning health malady worldwide. Islet or pancreas transplantation is the only long-term treatment available; however, the scarcity of…”
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A single extra copy of Down syndrome critical region 1–4 results in impaired hepatic glucose homeostasis by Seo, Dong Soo, Chau, Gia Cac, Baek, Kwan-Hyuck, Um, Sung Hee

“…During fasting, hepatic gluconeogenesis is induced to maintain energy homeostasis. Moreover, abnormal dysregulation of hepatic glucose production is commonly…”
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Overexpression of integrin αv correlates with poor prognosis in colorectal cancer by Ha, Sang Yun, Shin, Juyoun, Kim, Jeong Hoon, Kang, Myung Soo, Yoo, Hae-Yong, Kim, Hyeon-Ho, Um, Sung-Hee, Kim, Seok-Hyung

“…Integrin αv subunits are involved in tumour angiogenesis and tumour progression in various types of cancers. Clinical trials evaluating agents targeting…”
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Loss of S6K1 But Not S6K2 in the Tumor Microenvironment Suppresses Tumor Growth by Attenuating Tumor Angiogenesis by Lee, Seul, Roh, Hyun-Soo, Song, Seong-Soo, Shin, Jimin, Lee, Jangchoon, Bhang, Dong Ha, Kim, Byung Gak, Um, Sung Hee, Jeong, Han-Sin, Baek, Kwan-Hyuck

“…Two isoforms of the 70-kDa ribosomal protein S6 kinase, S6K1 and S6K2, have been identified and are considered key downstream effectors of the mTOR signaling…”
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SY14-3-3 S6K1:A determinant in embryonic-stem-cell commitment during early adipocyte differentiation by George Thomas, Larissa S.Carnevalli, Kouhei Masuda, Sung Hee Um, Nahum Sonenberg, Sara C.Kozma, George Thomas

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