Search Results - "Sung, Chang K."

CRISPR-mediated promoter de/methylation technologies for gene regulation by Sung, Chang K., Yim, Hyungshin

“…DNA methylation on cytosines of CpG dinucleotides is well established as a basis of epigenetic regulation in mammalian cells. Since aberrant regulation of DNA…”
Get full text

Roles of SALL2 in tumorigenesis by Sung, Chang K., Yim, Hyungshin

“…The proteins p150 Sal2 (product of SALL2 ) and p53 share growth arrest and pro-apoptotic functions by independently inducing p21 Cip1/Waf1 and BAX, and both…”
Get full text

Optimization of SOX2 Expression for Enhanced Glioblastoma Stem Cell Virotherapy by Kim, Dongwook, Puig, Abraham, Rabiei, Faranak, Hawkins, Erial J, Hernandez, Talia F, Sung, Chang K

“…The Zika virus has been shown to infect glioblastoma stem cells via the membrane receptor αvβ5, which is activated by the stem-specific transcription factor…”
Get full text

Mitotic protein kinase-driven crosstalk of machineries for mitosis and metastasis by Kim, Chang-Hyeon, Kim, Da-Eun, Kim, Dae-Hoon, Min, Ga-Hong, Park, Jung-Won, Kim, Yeo-Bin, Sung, Chang K., Yim, Hyungshin

“…Accumulating evidence indicates that mitotic protein kinases are involved in metastatic migration as well as tumorigenesis. Protein kinases and cytoskeletal…”
Get full text

The Optimal Balance between Oncolytic Viruses and Natural Killer Cells: A Mathematical Approach by Kim, Dongwook, Shin, Dong-Hoon, Sung, Chang K

“…Oncolytic virotherapy (OV) is a cancer therapy utilizing lytic viruses that specifically target cancer cells for elimination. In this relatively new therapy,…”
Get full text

Phosphorus and Nitrogen Drive the Seasonal Dynamics of Bacterial Communities in Pinus Forest Rhizospheric Soil of the Qinling Mountains by Wang, Hai H, Chu, Hong L, Dou, Qing, Xie, Qing Z, Tang, Ming, Sung, Chang K, Wang, Chun Y

“…The temporal distribution patterns of bacterial communities, as an important group in mountain soil, are affected by various environmental factors. To improve…”
Get full text

Clinical applications of circulating biomarkers in non-small cell lung cancer by Oh, Hyun-Ji, Imam-Aliagan, Abdulhamid B, Kim, Yeo-Bin, Kim, Hyun-Jin, Izaguirre, Issac A, Sung, Chang K, Yim, Hyungshin

“…Despite recent advances in cancer diagnostics and treatment, the mortality associated with lung cancer is still the highest in the world. Late-stage diagnosis,…”
Get full text

In vivo Optical Molecular Imaging of Vascular Endothelial Growth Factor for Monitoring Cancer Treatment by CHANG, Sung K, RIZVI, Imran, SOLBAN, Nicolas, HASAN, Tayyaba

“…Purpose: Vascular endothelial growth factor (VEGF) expression is a critical component in tumor growth and metastasis. Capabilities to monitor VEGF expression…”
Get full text

Nek1 and TAZ Interact to Maintain Normal Levels of Polycystin 2 by YIM, Hyungshin, SUNG, Chang K, YOU, John, YU TIAN, BENJAMIN, Thomas

“…Polycystic kidney disease (PKD) in mice can arise from defects in Nek kinases, which participate in ciliogenesis. PKD can also arise from loss of the protein…”
Get full text

Enhanced tolerance of transgenic potato plants expressing both superoxide dismutase and ascorbate peroxidase in chloroplasts against oxidative stress and high temperature by Tang, Li, Kwon, Suk-Yoon, Kim, Sun-Hyung, Kim, Jin-Seog, Choi, Jung Sup, Cho, Kwang Yun, Sung, Chang K, Kwak, Sang-Soo, Lee, Haeng-Soon

“…Oxidative stress is a major damaging factor for plants exposed to environmental stresses. In order to develop transgenic potato plants with enhanced tolerance…”
Get full text

Mechanistic investigation and implications of photodynamic therapy induction of vascular endothelial growth factor in prostate cancer by SOLBAN, Nicolas, PAL, Selbo K, ALOK, Sinha K, SUNG, Chang K, HASAN, Tayyaba

“…Photodynamic therapy (PDT) is now an approved therapeutic modality, and induction of vascular endothelial growth factor (VEGF) following subcurative PDT is of…”
Get full text

Promoter methylation of the SALL2 tumor suppressor gene in ovarian cancers by Sung, Chang K., Li, Dawei, Andrews, Erik, Drapkin, Ronny, Benjamin, Thomas

“…The SALL2 gene product and transcription factor p150 were first identified in a search for tumor suppressors targeted for inactivation by the oncogenic mouse…”
Get full text

A mechanism-based combination therapy reduces local tumor growth and metastasis in an orthotopic model of prostate cancer by KOSHARSKYY, Boleslav, SOLBAN, Nicolas, CHANG, Sung K, RIZVI, Imran, CHANG, Yuchiao, HASAN, Tayyaba

“…Therapy-induced stimulation of angiogenic molecules can promote tumor angiogenesis leading to enhanced tumor growth and cancer metastasis. Several standard and…”
Get full text

Murine Polyomavirus encodes a microRNA that cleaves early RNA transcripts but is not essential for experimental infection by Sullivan, Christopher S, Sung, Chang K, Pack, Christopher D, Grundhoff, Adam, Lukacher, Aron E, Benjamin, Thomas L, Ganem, Don

“…Abstract MicroRNAs are small regulatory RNAs that post-transcriptionally regulate gene expression and can be encoded by viral as well as cellular genomes. The…”
Get full text

DNA-binding and regulatory properties of the transcription factor and putative tumor suppressor p150(Sal2) by Gu, Hongcang, Li, Dawei, Sung, Chang K, Yim, Hyungshin, Troke, Philip, Benjamin, Thomas

“…The product of the SALL2 protein p150(Sal2) is a multi-zinc finger transcription factor with growth arrest and proapoptotic functions that overlap those of…”
Get more information

Transcriptional and post-translational regulation of the quiescence factor and putative tumor suppressor p150(Sal2) by Sung, Chang K, Dahl, Jean, Yim, Hyungshin, Rodig, Scott, Benjamin, Thomas L

“…The evolutionarily conserved SALL genes encode transcription factors with roles in embryonic development. The product of the SALL2 gene was first identified as…”
Get full text

Model-based analysis of clinical fluorescence spectroscopy for in vivo detection of cervical intraepithelial dysplasia by Chang, Sung K, Marin, Nena, Follen, Michele, Richards-Kortum, Rebecca

“…We present a mathematical model to calculate the relative concentration of light scatterers, light absorbers, and fluorophores in the epithelium and stroma…”
Get more information

Reflectance spectroscopy for in vivo detection of cervical precancer by Mirabal, Yvette N, Chang, Sung K, Atkinson, Edward Neely, Malpica, Anais, Follen, Michele, Richards-Kortum, Rebecca

“…Optical technologies, in particular fluorescence spectroscopy, have shown the potential to provide improved detection methods for cervical neoplasia that are…”
Get more information

Combined reflectance and fluorescence spectroscopy for in vivo detection of cervical pre-cancer by Chang, Sung K, Mirabal, Yvette N, Atkinson, Edward Neely, Cox, Dennis, Malpica, Anais, Follen, Michele, Richards-Kortum, Rebecca

“…Optical technologies, such as reflectance and fluorescence spectroscopy, have shown the potential to provide improved point-of-care detection methods for…”
Get more information

Reflectance spectroscopy for diagnosis of epithelial precancer: model-based analysis of fiber-optic probe designs to resolve spectral information from epithelium and stroma by Arifler, Dizem, Schwarz, Richard A, Chang, Sung K, Richards-Kortum, Rebecca

“…Reflectance spectroscopy is a promising technology for detection of epithelial precancer. Fiber-optic probes that selectively collect scattered light from both…”
Get more information