Search Results - "Sundrud, Mark S."

Emerging roles of bile acids in mucosal immunity and inflammation by Chen, Mei Lan, Takeda, Kiyoshi, Sundrud, Mark S.

“…Bile acids are cholesterol-derived surfactants that circulate actively between the liver and ileum and that are classically recognized for emulsifying dietary…”
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Targeting Th17 cells in autoimmune diseases by Yang, Jianfei, Sundrud, Mark S, Skepner, Jill, Yamagata, Tetsuya

“…Highlights • T helper 17 (Th17) cells have important functions in immunity and pathologic inflammation. • Targeting Th17 cells rather than single effector…”
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Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids by Ramesh, Radha, Kozhaya, Lina, McKevitt, Kelly, Djuretic, Ivana M, Carlson, Thaddeus J, Quintero, Maria A, McCauley, Jacob L, Abreu, Maria T, Unutmaz, Derya, Sundrud, Mark S

“…IL-17A-expressing CD4(+) T cells (Th17 cells) are generally regarded as key effectors of autoimmune inflammation. However, not all Th17 cells are…”
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Genetic and pharmacological inhibition of the nuclear receptor RORα regulates TH17 driven inflammatory disorders by Wang, Ran, Campbell, Sean, Amir, Mohammed, Mosure, Sarah A., Bassette, Molly A., Eliason, Amber, Sundrud, Mark S., Kamenecka, Theodore M., Solt, Laura A.

“…Full development of IL-17 producing CD4 + T helper cells (T H 17 cells) requires the transcriptional activity of both orphan nuclear receptors RORα and RORγt…”
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ATP-dependent transporters: emerging players at the crossroads of immunity and metabolism by Balasubramanian, Akshaya, Sundrud, Mark S

“…Nearly 50 ATP-binding cassette (ABC) transporters are encoded by mammalian genomes. These transporters are characterized by conserved nucleotide-binding and…”
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Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms by Xiao, Sheng, Yosef, Nir, Yang, Jianfei, Wang, Yonghui, Zhou, Ling, Zhu, Chen, Wu, Chuan, Baloglu, Erkan, Schmidt, Darby, Ramesh, Radha, Lobera, Mercedes, Sundrud, Mark S., Tsai, Pei-Yun, Xiang, Zhijun, Wang, Jinsong, Xu, Yan, Lin, Xichen, Kretschmer, Karsten, Rahl, Peter B., Young, Richard A., Zhong, Zhong, Hafler, David A., Regev, Aviv, Ghosh, Shomir, Marson, Alexander, Kuchroo, Vijay K.

“…We identified three retinoid-related orphan receptor gamma t (RORγt)-specific inhibitors that suppress T helper 17 (Th17) cell responses, including…”
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Identity crisis of Th17 cells: Many forms, many functions, many questions by Sundrud, Mark S, Trivigno, Catherine

“…Highlights • Th17 cells are potent regulators linked to induction and persistence of inflammation. • The human Th17 compartment is heterogeneous with pro- and…”
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Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase by Keller, Tracy L, Zocco, Davide, Sundrud, Mark S, Hendrick, Margaret, Edenius, Maja, Yum, Jinah, Kim, Yeon-Jin, Lee, Hak-Kyo, Cortese, Joseph F, Wirth, Dyann F, Dignam, John David, Rao, Anjana, Yeo, Chang-Yeol, Mazitschek, Ralph, Whitman, Malcolm

“…Halofuginone was recently shown to inhibit the differentiation of T helper 17 (T H 17) cells, which are associated with autoimmune diseases. The demonstration…”
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Regulation of Intestinal Inflammation by Dietary Fats by Basson, Abigail R, Chen, Christy, Sagl, Filip, Trotter, Ashley, Bederman, Ilya, Gomez-Nguyen, Adrian, Sundrud, Mark S, Ilic, Sanja, Cominelli, Fabio, Rodriguez-Palacios, Alex

“…With the epidemic of human obesity, dietary fats have increasingly become a focal point of biomedical research. Epidemiological studies indicate that high-fat…”
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Halofuginone Inhibits TH17 Cell Differentiation by Activating the Amino Acid Starvation Response by Sundrud, Mark S, Koralov, Sergei B, Feuerer, Markus, Calado, Dinis Pedro, Kozhaya, Aimee ElHed, Rhule-Smith, Ava, Lefebvre, Rachel E, Unutmaz, Derya, Mazitschek, Ralph, Waldner, Hanspeter, Whitman, Malcolm, Keller, Tracy, Rao, Anjana

“…A central challenge for improving autoimmune therapy is preventing inflammatory pathology without inducing generalized immunosuppression. T helper 17 (TH17)…”
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Artificial microbiome heterogeneity spurs six practical action themes and examples to increase study power-driven reproducibility by Basson, Abigail R., LaSalla, Alexandria, Lam, Gretchen, Kulpins, Danielle, Moen, Erika L., Sundrud, Mark S., Miyoshi, Jun, Ilic, Sanja, Theriault, Betty R., Cominelli, Fabio, Rodriguez-Palacios, Alexander

“…With >70,000 yearly publications using mouse data, mouse models represent the best engrained research system to address numerous biological questions across…”
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What’s old is new again: Batf transcription factors and Th9 cells by Sundrud, Mark S., Hogan, Simon P.

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SerpinB1 regulates homeostatic expansion of IL-17+ γδ and CD4+ Th17 cells by Zhao, Picheng, Hou, Lifei, Farley, Kalamo, Sundrud, Mark S., Remold‐OˈDonnell, Eileen

“…Gene‐deleted mice show that serpinB1 serves as an endogenous restraint to limit untoward expansion of lymphocytes with a Th17 phenotype. SerpinB1 is an…”
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Domain requirements and sequence specificity of DNA binding for the forkhead transcription factor FOXP3 by Koh, Kian Peng, Sundrud, Mark S, Rao, Anjana

“…The forkhead, winged-helix transcription factor FOXP3 is preferentially expressed in T regulatory (Treg) cells and is critical for their immunosuppressive…”
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Cytokine Networks and T-Cell Subsets in Inflammatory Bowel Diseases by Chen, Mei Lan, Sundrud, Mark S

“…Pathogenesis of the inflammatory bowel diseases (IBDs), such as ulcerative colitis (UC) and Crohn's disease (CD), involve proinflammatory changes within the…”
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HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells by Oswald-Richter, Kyra, Grill, Stacy M, Shariat, Nikki, Leelawong, Mindy, Sundrud, Mark S, Haas, David W, Unutmaz, Derya

“…A T-cell subset, defined as CD4(+)CD25(hi) (regulatory T-cells [Treg cells]), was recently shown to suppress T-cell activation. We demonstrate that human Treg…”
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Inhibition of Primary Human T Cell Proliferation by Helicobacter pylori Vacuolating Toxin (VacA) Is Independent of VacA Effects on IL-2 Secretion by Sundrud, Mark S., Torres, Victor J., Unutmaz, Derya, Cover, Timothy L., Falkow, Stanley

“…Recent evidence indicates that the secreted Helicobacter pylori vacuolating toxin (VacA) inhibits the activation of T cells. VacA blocks IL-2 secretion in…”
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Informatics-Based Discovery of Disease-Associated Immune Profiles by Delmas, Amber, Oikonomopoulos, Angelos, Lacey, Precious N, Fallahi, Mohammad, Hommes, Daniel W, Sundrud, Mark S

“…Advances in flow and mass cytometry are enabling ultra-high resolution immune profiling in mice and humans on an unprecedented scale. However, the resulting…”
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Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis by Ghosh, Srimoyee, Koralov, Sergei B., Stevanovic, Irena, Sundrud, Mark S., Sasaki, Yoshiteru, Rajewsky, Klaus, Rao, Anjana, Müller, Martin R.

“…Nuclear factor of activated T cells (NFAT) proteins are a group of Ca 2+ -regulated transcription factors residing in the cytoplasm of resting cells…”
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Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics by Crompton, Joseph G, Sukumar, Madhusudhanan, Roychoudhuri, Rahul, Clever, David, Gros, Alena, Eil, Robert L, Tran, Eric, Hanada, Ken-Ichi, Yu, Zhiya, Palmer, Douglas C, Kerkar, Sid P, Michalek, Ryan D, Upham, Trevor, Leonardi, Anthony, Acquavella, Nicolas, Wang, Ena, Marincola, Francesco M, Gattinoni, Luca, Muranski, Pawel, Sundrud, Mark S, Klebanoff, Christopher A, Rosenberg, Steven A, Fearon, Douglas T, Restifo, Nicholas P

“…Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) results in complete regression of advanced cancer in some patients, but the…”
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