Search Results - "Sundrud, Mark"

Emerging roles of bile acids in mucosal immunity and inflammation by Chen, Mei Lan, Takeda, Kiyoshi, Sundrud, Mark S.

“…Bile acids are cholesterol-derived surfactants that circulate actively between the liver and ileum and that are classically recognized for emulsifying dietary…”
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Cytokine Networks and T-Cell Subsets in Inflammatory Bowel Diseases by Chen, Mei Lan, Sundrud, Mark S

“…Pathogenesis of the inflammatory bowel diseases (IBDs), such as ulcerative colitis (UC) and Crohn's disease (CD), involve proinflammatory changes within the…”
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Targeting Th17 cells in autoimmune diseases by Yang, Jianfei, Sundrud, Mark S, Skepner, Jill, Yamagata, Tetsuya

“…Highlights • T helper 17 (Th17) cells have important functions in immunity and pathologic inflammation. • Targeting Th17 cells rather than single effector…”
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Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids by Ramesh, Radha, Kozhaya, Lina, McKevitt, Kelly, Djuretic, Ivana M, Carlson, Thaddeus J, Quintero, Maria A, McCauley, Jacob L, Abreu, Maria T, Unutmaz, Derya, Sundrud, Mark S

“…IL-17A-expressing CD4(+) T cells (Th17 cells) are generally regarded as key effectors of autoimmune inflammation. However, not all Th17 cells are…”
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Genetic and pharmacological inhibition of the nuclear receptor RORα regulates TH17 driven inflammatory disorders by Wang, Ran, Campbell, Sean, Amir, Mohammed, Mosure, Sarah A., Bassette, Molly A., Eliason, Amber, Sundrud, Mark S., Kamenecka, Theodore M., Solt, Laura A.

“…Full development of IL-17 producing CD4 + T helper cells (T H 17 cells) requires the transcriptional activity of both orphan nuclear receptors RORα and RORγt…”
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Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms by Xiao, Sheng, Yosef, Nir, Yang, Jianfei, Wang, Yonghui, Zhou, Ling, Zhu, Chen, Wu, Chuan, Baloglu, Erkan, Schmidt, Darby, Ramesh, Radha, Lobera, Mercedes, Sundrud, Mark S., Tsai, Pei-Yun, Xiang, Zhijun, Wang, Jinsong, Xu, Yan, Lin, Xichen, Kretschmer, Karsten, Rahl, Peter B., Young, Richard A., Zhong, Zhong, Hafler, David A., Regev, Aviv, Ghosh, Shomir, Marson, Alexander, Kuchroo, Vijay K.

“…We identified three retinoid-related orphan receptor gamma t (RORγt)-specific inhibitors that suppress T helper 17 (Th17) cell responses, including…”
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ATP-dependent transporters: emerging players at the crossroads of immunity and metabolism by Balasubramanian, Akshaya, Sundrud, Mark S

“…Nearly 50 ATP-binding cassette (ABC) transporters are encoded by mammalian genomes. These transporters are characterized by conserved nucleotide-binding and…”
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Identity crisis of Th17 cells: Many forms, many functions, many questions by Sundrud, Mark S, Trivigno, Catherine

“…Highlights • Th17 cells are potent regulators linked to induction and persistence of inflammation. • The human Th17 compartment is heterogeneous with pro- and…”
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Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase by Keller, Tracy L, Zocco, Davide, Sundrud, Mark S, Hendrick, Margaret, Edenius, Maja, Yum, Jinah, Kim, Yeon-Jin, Lee, Hak-Kyo, Cortese, Joseph F, Wirth, Dyann F, Dignam, John David, Rao, Anjana, Yeo, Chang-Yeol, Mazitschek, Ralph, Whitman, Malcolm

“…Halofuginone was recently shown to inhibit the differentiation of T helper 17 (T H 17) cells, which are associated with autoimmune diseases. The demonstration…”
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Artificial microbiome heterogeneity spurs six practical action themes and examples to increase study power-driven reproducibility by Basson, Abigail R., LaSalla, Alexandria, Lam, Gretchen, Kulpins, Danielle, Moen, Erika L., Sundrud, Mark S., Miyoshi, Jun, Ilic, Sanja, Theriault, Betty R., Cominelli, Fabio, Rodriguez-Palacios, Alexander

“…With >70,000 yearly publications using mouse data, mouse models represent the best engrained research system to address numerous biological questions across…”
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Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics by Crompton, Joseph G, Sukumar, Madhusudhanan, Roychoudhuri, Rahul, Clever, David, Gros, Alena, Eil, Robert L, Tran, Eric, Hanada, Ken-Ichi, Yu, Zhiya, Palmer, Douglas C, Kerkar, Sid P, Michalek, Ryan D, Upham, Trevor, Leonardi, Anthony, Acquavella, Nicolas, Wang, Ena, Marincola, Francesco M, Gattinoni, Luca, Muranski, Pawel, Sundrud, Mark S, Klebanoff, Christopher A, Rosenberg, Steven A, Fearon, Douglas T, Restifo, Nicholas P

“…Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) results in complete regression of advanced cancer in some patients, but the…”
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Regulation of Intestinal Inflammation by Dietary Fats by Basson, Abigail R, Chen, Christy, Sagl, Filip, Trotter, Ashley, Bederman, Ilya, Gomez-Nguyen, Adrian, Sundrud, Mark S, Ilic, Sanja, Cominelli, Fabio, Rodriguez-Palacios, Alex

“…With the epidemic of human obesity, dietary fats have increasingly become a focal point of biomedical research. Epidemiological studies indicate that high-fat…”
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Halofuginone Inhibits TH17 Cell Differentiation by Activating the Amino Acid Starvation Response by Sundrud, Mark S, Koralov, Sergei B, Feuerer, Markus, Calado, Dinis Pedro, Kozhaya, Aimee ElHed, Rhule-Smith, Ava, Lefebvre, Rachel E, Unutmaz, Derya, Mazitschek, Ralph, Waldner, Hanspeter, Whitman, Malcolm, Keller, Tracy, Rao, Anjana

“…A central challenge for improving autoimmune therapy is preventing inflammatory pathology without inducing generalized immunosuppression. T helper 17 (TH17)…”
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What’s old is new again: Batf transcription factors and Th9 cells by Sundrud, Mark S., Hogan, Simon P.

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CAR directs T cell adaptation to bile acids in the small intestine by Chen, Mei Lan, Huang, Xiangsheng, Wang, Hongtao, Hegner, Courtney, Liu, Yujin, Shang, Jinsai, Eliason, Amber, Diao, Huitian, Park, HaJeung, Frey, Blake, Wang, Guohui, Mosure, Sarah A., Solt, Laura A., Kojetin, Douglas J., Rodriguez-Palacios, Alex, Schady, Deborah A., Weaver, Casey T., Pipkin, Matthew E., Moore, David D., Sundrud, Mark S.

“…Bile acids are lipid-emulsifying metabolites synthesized in hepatocytes and maintained in vivo through enterohepatic circulation between the liver and small…”
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Xenobiotic and endobiotic handling by the mucosal immune system by Chen, Mei Lan, Sundrud, Mark S

“…PURPOSE OF REVIEWMucosal immune cells in the intestinal tract are continuously exposed to a barrage of both foreign and endogenously generated metabolites,…”
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Role of Dysregulated Cytokine Signaling and Bacterial Triggers in the Pathogenesis of Cutaneous T-Cell Lymphoma by Fanok, Melania H., Sun, Amy, Fogli, Laura K., Narendran, Vijay, Eckstein, Miriam, Kannan, Kasthuri, Dolgalev, Igor, Lazaris, Charalampos, Heguy, Adriana, Laird, Mary E., Sundrud, Mark S., Liu, Cynthia, Kutok, Jeff, Lacruz, Rodrigo S., Latkowski, Jo-Ann, Aifantis, Iannis, Ødum, Niels, Hymes, Kenneth B., Goel, Swati, Koralov, Sergei B.

“…Cutaneous T-cell lymphoma is a heterogeneous group of lymphomas characterized by the accumulation of malignant T cells in the skin. The molecular and cellular…”
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Development of a putative Zn2+-chelating but highly selective MMP-13 inhibitor by Fuerst, Rita, Choi, Jun Yong, Knapinska, Anna M., Cameron, Michael D., Ruiz, Claudia, Delmas, Amber, Sundrud, Mark S., Fields, Gregg B., Roush, William R.

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Physiological expression and function of the MDR1 transporter in cytotoxic T lymphocytes by Chen, Mei Lan, Sun, Amy, Cao, Wei, Eliason, Amber, Mendez, Kayla M, Getzler, Adam J, Tsuda, Shanel, Diao, Huitian, Mukori, Clever, Bruno, Nelson E, Kim, Sang Yong, Pipkin, Matthew E, Koralov, Sergei B, Sundrud, Mark S

“…Multidrug resistance-1 (MDR1) acts as a chemotherapeutic drug efflux pump in tumor cells, although its physiological functions remain enigmatic. Using a…”
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The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids by Cao, Wei, Kayama, Hisako, Chen, Mei Lan, Delmas, Amber, Sun, Amy, Kim, Sang Yong, Rangarajan, Erumbi S., McKevitt, Kelly, Beck, Amanda P., Jackson, Cody B., Crynen, Gogce, Oikonomopoulos, Angelos, Lacey, Precious N., Martinez, Gustavo J., Izard, Tina, Lorenz, Robin G., Rodriguez-Palacios, Alex, Cominelli, Fabio, Abreu, Maria T., Hommes, Daniel W., Koralov, Sergei B., Takeda, Kiyoshi, Sundrud, Mark S.

“…CD4+ T cells are tightly regulated by microbiota in the intestine, but whether intestinal T cells interface with host-derived metabolites is less clear. Here,…”
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