Search Results - "Sundquist, Wesley I."

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  1. 1

    Virus Budding and the ESCRT Pathway by Votteler, Jörg, Sundquist, Wesley I.

    Published in Cell host & microbe (11-09-2013)
    “…Enveloped viruses escape infected cells by budding through limiting membranes. In the decade since the discovery that HIV recruits cellular ESCRT (endosomal…”
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  2. 2

    Structures, Functions, and Dynamics of ESCRT-III Vps4 Membrane Remodeling and Fission Complexes by McCullough, John, Frost, Adam, Sundquist, Wesley I

    “…The endosomal sorting complexes required for transport (ESCRT) pathway mediates cellular membrane remodeling and fission reactions. The pathway comprises five…”
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  3. 3

    Membrane fission reactions of the mammalian ESCRT pathway by McCullough, John, Colf, Leremy A, Sundquist, Wesley I

    Published in Annual review of biochemistry (01-01-2013)
    “…The endosomal sorting complexes required for transport (ESCRT) pathway was initially defined in yeast genetic screens that identified the factors necessary to…”
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  4. 4

    Reconstitution and visualization of HIV-1 capsid-dependent replication and integration in vitro by Christensen, Devin E, Ganser-Pornillos, Barbie K, Johnson, Jarrod S, Pornillos, Owen, Sundquist, Wesley I

    “…During the first half of the viral life cycle, HIV-1 reverse transcribes its RNA genome and integrates the double-stranded DNA copy into a host cell…”
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  5. 5

    The tripartite motif coiled-coil is an elongated antiparallel hairpin dimer by Sanchez, Jacint G., Okreglicka, Katarzyna, Chandrasekaran, Viswanathan, Welker, Jordan M., Sundquist, Wesley I., Pornillos, Owen

    “…Tripartite motif (TRIM) proteins make up a large family of coiled-coil-containing RING E3 ligases that function in many cellular processes, particularly innate…”
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  6. 6

    LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells by Gu, Mingyu, LaJoie, Dollie, Chen, Opal S., von Appen, Alexander, Ladinsky, Mark S., Redd, Michael J., Nikolova, Linda, Bjorkman, Pamela J., Sundquist, Wesley I., Ullman, Katharine S., Frost, Adam

    “…Endosomal sorting complexes required for transport III (ESCRT-III) proteins have been implicated in sealing the nuclear envelope in mammals, spindle pole body…”
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  7. 7

    Membrane constriction and thinning by sequential ESCRT-III polymerization by Nguyen, Henry C., Talledge, Nathaniel, McCullough, John, Sharma, Abhimanyu, Moss, Frank R., Iwasa, Janet H., Vershinin, Michael D., Sundquist, Wesley I., Frost, Adam

    Published in Nature structural & molecular biology (01-04-2020)
    “…The endosomal sorting complexes required for transport (ESCRTs) mediate diverse membrane remodeling events. These typically require ESCRT-III proteins to…”
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  8. 8

    Designed proteins induce the formation of nanocage-containing extracellular vesicles by Votteler, Jörg, Ogohara, Cassandra, Yi, Sue, Hsia, Yang, Nattermann, Una, Belnap, David M., King, Neil P., Sundquist, Wesley I.

    Published in Nature (London) (08-12-2016)
    “…Autonomously produced hybrid biological nanomaterials termed ‘enveloped protein nanocages’ incorporate features for membrane binding, self-assembly, and ESCRT…”
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  9. 9
  10. 10

    Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase by Monroe, Nicole, Han, Han, Shen, Peter S, Sundquist, Wesley I, Hill, Christopher P

    Published in eLife (05-04-2017)
    “…Many important cellular membrane fission reactions are driven by ESCRT pathways, which culminate in disassembly of ESCRT-III polymers by the AAA ATPase Vps4…”
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  11. 11

    The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets by Han, Han, Monroe, Nicole, Sundquist, Wesley I, Shen, Peter S, Hill, Christopher P

    Published in eLife (22-11-2017)
    “…The hexameric AAA ATPase Vps4 drives membrane fission by remodeling and disassembling ESCRT-III filaments. Building upon our earlier 4.3 Å resolution cryo-EM…”
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  12. 12

    Stephan Oroszlan and the Proteolytic Processing of Retroviral Proteins: Following A Pro by Swanstrom, Ronald, Sundquist, Wesley I

    Published in Viruses (04-11-2021)
    “…Steve Oroszlan determined the sequences at the ends of virion proteins for a number of different retroviruses. This work led to the insight that the…”
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  13. 13

    Hexagonal assembly of a restricting TRIM5α protein by Ganser-Pornillos, Barbie K, Chandrasekaran, Viswanathan, Pornillos, Owen, Sodroski, Joseph G, Sundquist, Wesley I, Yeager, Mark

    “…TRIM5α proteins are restriction factors that protect mammalian cells from retroviral infections by binding incoming viral capsids, accelerating their…”
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  14. 14

    Retrovirus budding by Morita, Eiji, Sundquist, Wesley I

    “…Human immunodeficiency virus (HIV) and other retroviruses acquire their envelopes and spread infection by budding through the limiting membranes of producer…”
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  15. 15

    X-Ray Structures of the Hexameric Building Block of the HIV Capsid by Pornillos, Owen, Ganser-Pornillos, Barbie K., Kelly, Brian N., Hua, Yuanzi, Whitby, Frank G., Stout, C. David, Sundquist, Wesley I., Hill, Christopher P., Yeager, Mark

    Published in Cell (26-06-2009)
    “…The mature capsids of HIV and other retroviruses organize and package the viral genome and its associated enzymes for delivery into host cells. The HIV capsid…”
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  16. 16

    The molecular mechanism of hepcidin-mediated ferroportin down-regulation by De Domenico, Ivana, Ward, Diane McVey, Langelier, Charles, Vaughn, Michael B, Nemeth, Elizabeta, Sundquist, Wesley I, Ganz, Tomas, Musci, Giovanni, Kaplan, Jerry

    Published in Molecular biology of the cell (01-07-2007)
    “…Ferroportin (Fpn) is the only known iron exporter in vertebrates. Hepcidin, a peptide secreted by the liver in response to iron or inflammation, binds to Fpn,…”
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  17. 17

    ALIX-CHMP4 interactions in the human ESCRT pathway by McCullough, John, Fisher, Robert D, Whitby, Frank G, Sundquist, Wesley I, Hill, Christopher P

    “…The ESCRT pathway facilitates membrane fission events during enveloped virus budding, multivesicular body formation, and cytokinesis. To promote HIV budding…”
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  18. 18

    Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance by Morita, Eiji, Colf, Leremy A., Karren, Mary Anne, Sandrin, Virginie, Rodesch, Christopher K., Sundquist, Wesley I., Lamb, Robert A.

    “…The ESCRT pathway helps mediate the final abscission step of cytokinesis in mammals and archaea. In mammals, two early acting proteins of the ESCRT pathway,…”
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  19. 19

    Specific Recognition and Accelerated Uncoating of Retroviral Capsids by the TRIM5α Restriction Factor by Stremlau, Matthew, Perron, Michel, Lee, Mark, Li, Yuan, Song, Byeongwoon, Javanbakht, Hassan, Diaz-Griffero, Felipe, Anderson, Donovan J., Sundquist, Wesley I., Sodroski, Joseph

    “…The host restriction factor TRIM5a mediates species-specific, early blocks to retrovirus infection; susceptibility to these blocks is determined by viral…”
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  20. 20

    Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission by Wenzel, Dawn M, Mackay, Douglas R, Skalicky, Jack J, Paine, Elliott L, Miller, Matthew S, Ullman, Katharine S, Sundquist, Wesley I

    Published in eLife (15-09-2022)
    “…The 12 related human ESCRT-III proteins form filaments that constrict membranes and mediate fission, including during cytokinetic abscission. The C-terminal…”
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