Search Results - "Sundquist, Wesley I."
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Virus Budding and the ESCRT Pathway
Published in Cell host & microbe (11-09-2013)“…Enveloped viruses escape infected cells by budding through limiting membranes. In the decade since the discovery that HIV recruits cellular ESCRT (endosomal…”
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2
Structures, Functions, and Dynamics of ESCRT-III Vps4 Membrane Remodeling and Fission Complexes
Published in Annual review of cell and developmental biology (06-10-2018)“…The endosomal sorting complexes required for transport (ESCRT) pathway mediates cellular membrane remodeling and fission reactions. The pathway comprises five…”
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3
Membrane fission reactions of the mammalian ESCRT pathway
Published in Annual review of biochemistry (01-01-2013)“…The endosomal sorting complexes required for transport (ESCRT) pathway was initially defined in yeast genetic screens that identified the factors necessary to…”
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4
Reconstitution and visualization of HIV-1 capsid-dependent replication and integration in vitro
Published in Science (American Association for the Advancement of Science) (09-10-2020)“…During the first half of the viral life cycle, HIV-1 reverse transcribes its RNA genome and integrates the double-stranded DNA copy into a host cell…”
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5
The tripartite motif coiled-coil is an elongated antiparallel hairpin dimer
Published in Proceedings of the National Academy of Sciences - PNAS (18-02-2014)“…Tripartite motif (TRIM) proteins make up a large family of coiled-coil-containing RING E3 ligases that function in many cellular processes, particularly innate…”
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6
LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells
Published in Proceedings of the National Academy of Sciences - PNAS (14-03-2017)“…Endosomal sorting complexes required for transport III (ESCRT-III) proteins have been implicated in sealing the nuclear envelope in mammals, spindle pole body…”
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7
Membrane constriction and thinning by sequential ESCRT-III polymerization
Published in Nature structural & molecular biology (01-04-2020)“…The endosomal sorting complexes required for transport (ESCRTs) mediate diverse membrane remodeling events. These typically require ESCRT-III proteins to…”
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8
Designed proteins induce the formation of nanocage-containing extracellular vesicles
Published in Nature (London) (08-12-2016)“…Autonomously produced hybrid biological nanomaterials termed ‘enveloped protein nanocages’ incorporate features for membrane binding, self-assembly, and ESCRT…”
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9
Structure and membrane remodeling activity of ESCRT-III helical polymers
Published in Science (American Association for the Advancement of Science) (18-12-2015)“…The endosomal sorting complexes required for transport (ESCRT) proteins mediate fundamental membrane remodeling events that require stabilizing negative…”
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10
Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase
Published in eLife (05-04-2017)“…Many important cellular membrane fission reactions are driven by ESCRT pathways, which culminate in disassembly of ESCRT-III polymers by the AAA ATPase Vps4…”
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11
The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets
Published in eLife (22-11-2017)“…The hexameric AAA ATPase Vps4 drives membrane fission by remodeling and disassembling ESCRT-III filaments. Building upon our earlier 4.3 Å resolution cryo-EM…”
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12
Stephan Oroszlan and the Proteolytic Processing of Retroviral Proteins: Following A Pro
Published in Viruses (04-11-2021)“…Steve Oroszlan determined the sequences at the ends of virion proteins for a number of different retroviruses. This work led to the insight that the…”
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13
Hexagonal assembly of a restricting TRIM5α protein
Published in Proceedings of the National Academy of Sciences - PNAS (11-01-2011)“…TRIM5α proteins are restriction factors that protect mammalian cells from retroviral infections by binding incoming viral capsids, accelerating their…”
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Retrovirus budding
Published in Annual review of cell and developmental biology (01-01-2004)“…Human immunodeficiency virus (HIV) and other retroviruses acquire their envelopes and spread infection by budding through the limiting membranes of producer…”
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X-Ray Structures of the Hexameric Building Block of the HIV Capsid
Published in Cell (26-06-2009)“…The mature capsids of HIV and other retroviruses organize and package the viral genome and its associated enzymes for delivery into host cells. The HIV capsid…”
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16
The molecular mechanism of hepcidin-mediated ferroportin down-regulation
Published in Molecular biology of the cell (01-07-2007)“…Ferroportin (Fpn) is the only known iron exporter in vertebrates. Hepcidin, a peptide secreted by the liver in response to iron or inflammation, binds to Fpn,…”
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17
ALIX-CHMP4 interactions in the human ESCRT pathway
Published in Proceedings of the National Academy of Sciences - PNAS (03-06-2008)“…The ESCRT pathway facilitates membrane fission events during enveloped virus budding, multivesicular body formation, and cytokinesis. To promote HIV budding…”
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Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance
Published in Proceedings of the National Academy of Sciences - PNAS (20-07-2010)“…The ESCRT pathway helps mediate the final abscission step of cytokinesis in mammals and archaea. In mammals, two early acting proteins of the ESCRT pathway,…”
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19
Specific Recognition and Accelerated Uncoating of Retroviral Capsids by the TRIM5α Restriction Factor
Published in Proceedings of the National Academy of Sciences - PNAS (04-04-2006)“…The host restriction factor TRIM5a mediates species-specific, early blocks to retrovirus infection; susceptibility to these blocks is determined by viral…”
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20
Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission
Published in eLife (15-09-2022)“…The 12 related human ESCRT-III proteins form filaments that constrict membranes and mediate fission, including during cytokinetic abscission. The C-terminal…”
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