Search Results - "Sundermeier, Thomas R"

The physiological impact of microRNA gene regulation in the retina by Sundermeier, Thomas R., Palczewski, Krzysztof

“…microRNAs (miRNAs) are small, stable RNA molecules that post-transcriptionally regulate gene expression in plants and animals by base pairing to partially…”
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MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice by Sundermeier, Thomas R, Sakami, Sanae, Sahu, Bhubanananda, Howell, Scott J, Gao, Songqi, Dong, Zhiqian, Golczak, Marcin, Maeda, Akiko, Palczewski, Krzysztof

“…Age-related macular degeneration (AMD) is a major cause of irreversible vision loss. The neovascular or "wet" form of AMD can be treated to varying degrees…”
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Expression pattern of Ccr2 and Cx3cr1 in inherited retinal degeneration by Kohno, Hideo, Koso, Hideto, Okano, Kiichiro, Sundermeier, Thomas R, Saito, Saburo, Watanabe, Sumiko, Tsuneoka, Hiroshi, Sakai, Tsutomu

“…Though accumulating evidence suggests that microglia, resident macrophages in the retina, and bone marrow-derived macrophages can cause retinal inflammation…”
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DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice by Sundermeier, Thomas R., Zhang, Ning, Vinberg, Frans, Mustafi, Debarshi, Kohno, Hideo, Golczak, Marcin, Bai, Xiaodong, Maeda, Akiko, Kefalov, Vladimir J., Palczewski, Krzysztof

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The impact of microRNA gene regulation on the survival and function of mature cell types in the eye by Sundermeier, Thomas R., Palczewski, Krzysztof

“…ABSTRACT MicroRNAs (miRNAs) regulate multiple genes, often within the same pathway, fine‐tuning expression of key factors and stabilizing gene networks against…”
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Functional SmpB-Ribosome Interactions Require tmRNA by Sundermeier, Thomas R., Karzai, A. Wali

“…Small protein B (SmpB) is a requisite component of the transfer messenger RNA (tmRNA)-mediated bacterial translational quality control system known as…”
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A Previously Uncharacterized Role for Small Protein B (SmpB) in Transfer Messenger RNA-Mediated Trans-Translation by Sundermeier, Thomas R., Dulebohn, Daniel P., Cho, Hye Jin, Karzai, A. Wali, Lennarz, William J.

“…SsrA is a versatile RNA molecule found in all bacteria that functions as both a tRNA and an mRNA. SsrA rescues ribosomes stalled on damaged mRNAs and directs…”
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DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice by Sundermeier, Thomas R., Zhang, Ning, Vinberg, Frans, Mustafi, Debarshi, Kohno, Hideo, Golczak, Marcin, Bai, Xiaodong, Maeda, Akiko, Kefalov, Vladimir J., Palczewski, Krzysztof

“…Photoreceptor cell death is the proximal cause of blindness in many retinal degenerative disorders; hence, understanding the gene regulatory networks that…”
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R9AP overexpression alters phototransduction kinetics in iCre75 mice by Sundermeier, Thomas R, Vinberg, Frans, Mustafi, Debarshi, Bai, Xiaodong, Kefalov, Vladimir J, Palczewski, Krzysztof

“…Determine the impact of rod photoreceptor-specific expression of Cre recombinase on the kinetics of phototransduction in the mouse eye and identify changes in…”
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Argonaute High-Throughput Sequencing of RNAs Isolated by Cross-Linking Immunoprecipitation Reveals a Snapshot of miRNA Gene Regulation in the Mammalian Retina by Sundermeier, Thomas R, Jin, Hui, Kleinjan, Matthew L, Mustafi, Debarshi, Licatalosi, Donny D, Palczewski, Krzysztof

“…Mounting evidence points to roles for miRNA gene regulation in promoting development, function, and cell survival in the mammalian retina. However, little is…”
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Understanding how miRNAs post-transcriptionally regulate gene expression by Fabian, Marc R, Sundermeier, Thomas R, Sonenberg, Nahum

“…The discovery of microRNA (miRNA)-mediated gene silencing has added a new level of complexity to our understanding of post-transcriptional control of gene…”
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MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in MiceThis research was supported in part by National Institutes of Health Grants EY022326 and EY R24024864 (to K. P.), EY022658 (to A. M.), EY023948 (to M. G.), and P30EY011373 (from the VSRC CORE grant). This work was also supported by the Arnold and Mabel Beckman Foundation and the Foundation Fighting Blindness. The authors declare that they have no conflicts of interest with the by Sundermeier, Thomas R., Sakami, Sanae, Sahu, Bhubanananda, Howell, Scott J., Gao, Songqi, Dong, Zhiqian, Golczak, Marcin, Maeda, Akiko, Palczewski, Krzysztof

“…Age-related macular degeneration (AMD) is a major cause of irreversible vision loss. The neovascular or “wet” form of AMD can be treated to varying degrees…”
Get full text