Search Results - "Sundelof, J G"

Preliminary animal pharmacokinetics of the parenteral antifungal agent MK-0991 (L-743,872) by HAJDU, R, THOMPSON, R, SUNDELOF, J. G, PELAK, B. A, BOUFFARD, F. A, DROPINSKI, J. F, KROPP, H

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Pharmacokinetics of L-749,345, a long-acting carbapenem antibiotic, in primates by SUNDELOF, J. G, HAJDU, R, GILL, C. J, THOMPSON, R, ROSEN, H, KROPP, H

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In Vivo Activity and Pharmacokinetic Evaluation of a Novel Long-Acting Carbapenem Antibiotic, MK-826 (L-749,345) by GILL, C. J, JACKSON, J. J, GERCKENS, L. S, PELAK, B. A, THOMPSON, R. K, SUNDELOF, J. G, KROPP, H, ROSEN, H

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Dicationic 2-fluorenonylcarbapenems: Potent anti-MRS agents with improved solubility and pharmacokinetic properties by Greenlee, Mark L., Laub, Joanne B., Rouen, Gregory P., DiNinno, Frank, Hammond, Milton L., Huber, Joann L., Sundelof, Jon G., Hammond, Gail G.

“…The synthesis and biological evaluation of a series of dicationic-substituted 2-fluorenonylcarbapenems is described. This class of compounds showed enhanced…”
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Synthesis and properties of 2-(naphthosultamyl)methyl-carbapenems with potent anti-MRSA activity: Discovery of L-786,392 by Ratcliffe, R.W., Wilkening, R.R., Wildonger, K.J., Waddell, S.T., Santorelli, G.M., Parker, D.L., Morgan, J.D., Blizzard, T.A., Hammond, M.L., Heck, J.V., Huber, J., Kohler, J., Dorso, K.L., St. Rose, E., Sundelof, J.G., May, W.J., Hammond, G.G.

“…A series of 1β-methyl-2-(naphthosultamyl)methyl-carbapenems bearing dicationic groups on the naphthosultamyl moiety was prepared and evaluated for activity…”
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Pharmacokinetics in nonhuman primates of a prototype carbapenem active against methicillin-resistant Staphylococcus aureus by SUNDELOF, J. G, THOMPSON, R, WHITE, K. M, SASOR, M. W, CAMA, L, KROPP, H

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The synthesis and anti-MRSA activity of amidinium-substituted 2-dibenzofuranylcarbapenems by Laub, Joanne B., Greenlee, Mark L., DiNinno, Frank, Huber, Joann L., Sundelof, Jon G.

“…A series of amidinium-substituted 2-dibenzofuranylcarbapenems with potent activity against MRSA has been synthesized via a Stille cross-coupling reaction…”
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Urinary Recovery of N-Formimidoyl Thienamycin (MK0787) as Affected by Coadministration of N-Formimidoyl Thienamycin Dehydropeptidase Inhibitors by Norrby, S R, Alestig, K, Björnegård, B, Burman, L A, Ferber, F, Huber, J L, Jones, K H, Kahan, F M, Kahan, J S, Kropp, H, Meisinger, M A, Sundelof, J G

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Pharmacokinetics of L-671,329 in rhesus monkeys and DBA/2 mice by SUNDELOF, J. G, HAJDU, R, CLEARE, W. J, ONISHI, J, KROPP, H

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MK0787 (N-formimidoyl thienamycin): evaluation of in vitro and in vivo activities by Kropp, H, Sundelof, J G, Kahan, J S, Kahan, F M, Birnbaum, J

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Reduced Immunotoxicity and Preservation of Antibacterial Activity in a Releasable Side-Chain Carbapenem Antibiotic by Rosen, Hugh, Hajdu, Richard, Silver, Lynn, Kropp, Helmut, Dorso, Karen, Kohler, Joyce, Sundelof, Jon G., Huber, Joann, Hammond, Gail G., Jackson, Jesse J., Gill, Charles J., Thompson, Randall, Pelak, Barbara A., Epstein-Toney, Jeffrey H., Lankas, George, Wilkening, Robert R., Wildonger, Kenneth J., Blizzard, Timothy A., DiNinno, Frank P., Ratcliffe, Ronald W., Heck, James V., Kozarich, John W., Hammond, Milton L.

“…A carbapenem antibiotic, L-786,392, was designed so that the side chain that provides high-affinity binding to the penicillin-binding proteins responsible for…”
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Metabolism of Thienamycin and Related Carbapenem Antibiotics by the Renal Dipeptidase, Dehydropeptidase-I by Kropp, Helmut, Sundelof, Jon G, Hajdu, Richard, Kahan, Frederick M

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Antibacterial Activity of Imipenem: The First Thienamycin Antibiotic by Kropp, Helmut, Lynn Gerckens, Sundelof, Jon G., Kahan, Frederick M.

“…Imipenem (N-formimidoyl thienamycin) is the first representative of a new class of β-lactam antibiotics - the carbapenems. Imipenem has an unusually broad…”
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Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-β-lactamase by Toney, Jeffrey H., Fitzgerald, Paula M.D., Grover-Sharma, Nandini, Olson, Steven H., May, Walter J., Sundelof, Jon G., Vanderwall, Dana E., Cleary, Kelly A., Grant, Stephan K., Wu, Joseph K., Kozarich, John W., Pompliano, David L., Hammond, Gail G.

“…Background: High level resistance to carbapenem antibiotics in gram negative bacteria such as Bacteroides fragilis is caused, in part, by expression of a…”
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Thienamycin: development of imipenen-cilastatin by Kahan, F M, Kropp, H, Sundelof, J G, Birnbaum, J

“…Thienamycin, a natural product produced by Streptomyces cattleya is the first representative of a unique class of beta-lactam antibiotics, the carbapenems…”
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Metabolism of thienamycin and related carbapenem antibiotics by the renal dipeptidase, dehydropeptidase by Kropp, H, Sundelof, J G, Hajdu, R, Kahan, F M

“…Thienamycin (THM), the N-formimidoyl thienamycin derivative MK0787, and related carbapenem antibiotics were metabolized extensively in mice, rats, rabbits,…”
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Benzothiazolylthio carbapenems: potent anti-MRSA agents by Waddell, Sherman T., Ratcliffe, Ronald W., Szumiloski, Sandra P., Wildonger, Kenneth J., Wilkening, Robert R., Blizzard, Timothy A., Huber, Joann, Kohler, Joyce, Dorso, Karen, Rose, Earl St, Sundelof, Jon G., Hammond, Gail G.

“…A series of sulfur-linked benzothiazolyl carbapenems has been prepared and evaluated against a battery of microorganisms. Many of the compounds displayed good…”
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