Role of Circulating Cell-Free DNA in Cancers

Liquid biopsy is a term used to describe non-invasive tests, which provide information about disease conditions through analysis of circulating cell-free DNA and circulating tumor cells from peripheral blood samples. In patients with cancer, the concentration of cell-free DNA increases, and structur...

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Bibliographic Details
Published in:	Molecular diagnosis & therapy Vol. 19; no. 6; pp. 339 - 350
Main Authors:	Aarthy, Raghu, Mani, Samson, Velusami, Sridevi, Sundarsingh, Shirley, Rajkumar, Thangarajan
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01-12-2015 Springer Nature B.V
Subjects:	Animals Apoptosis Biomarkers Biomarkers, Tumor - blood Biomedical and Life Sciences Biomedicine Biopsy Breast cancer Cancer Research Cell Transformation, Neoplastic - genetics Deoxyribonucleic acid Disease DNA DNA methylation DNA, Neoplasm - blood Gangrene Gastric cancer Genes Heart attacks High-Throughput Nucleotide Sequencing Human Genetics Humans Laboratory Medicine Medical diagnosis Medical prognosis Metastasis Molecular Medicine Molecular weight Neoplasm Metastasis Neoplasms - blood Neoplasms - diagnosis Neoplasms - genetics Neoplasms - pathology Patients Pharmacotherapy Plasma Proteins Real-Time Polymerase Chain Reaction Review Article Tumors Peptide Nucleic Acid KRAS Gene Massive Parallel Sequencing EGFR Mutation RASSF1A Methylation
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Summary:	Liquid biopsy is a term used to describe non-invasive tests, which provide information about disease conditions through analysis of circulating cell-free DNA and circulating tumor cells from peripheral blood samples. In patients with cancer, the concentration of cell-free DNA increases, and structural, sequence, and epigenetic changes to DNA can be observed through the disease process and during therapy. Furthermore, cell-free DNA released by the tumor contains the same variants as those in the tumor cells. Therefore, cell-free DNA allows non-invasive assessment of cancer in real time. This review summarizes the origin of cell-free DNA, recent advancements in the detection of cell-free DNA, a possible role in metastasis, and its importance as a non-invasive diagnostic assay for cancer.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1177-1062 1179-2000
DOI:	10.1007/s40291-015-0167-y