Search Results - "Sundar, Purnima D"

Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire by Glanville, Jacob, Zhai, Wenwu, Berka, Jan, Telman, Dilduz, Huerta, Gabriella, Mehta, Gautam R, Ni, Irene, Mei, Li, Sundar, Purnima D, Day, Giles M.R, Cox, David, Rajpal, Arvind, Pons, Jaume

“…Antibody repertoire diversity, potentially as high as 10¹¹ unique molecules in a single individual, confounds characterization by conventional sequence…”
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Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis by Palanichamy, Arumugam, Apeltsin, Leonard, Kuo, Tracy C, Sirota, Marina, Wang, Shengzhi, Pitts, Steven J, Sundar, Purnima D, Telman, Dilduz, Zhao, Lora Z, Derstine, Mia, Abounasr, Aya, Hauser, Stephen L, von Büdingen, H-Christian

“…In multiple sclerosis (MS), lymphocyte--in particular B cell--transit between the central nervous system (CNS) and periphery may contribute to the maintenance…”
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B cell exchange across the blood-brain barrier in multiple sclerosis by von Büdingen, H-Christian, Kuo, Tracy C, Sirota, Marina, van Belle, Christopher J, Apeltsin, Leonard, Glanville, Jacob, Cree, Bruce A, Gourraud, Pierre-Antoine, Schwartzburg, Amy, Huerta, Gabriella, Telman, Dilduz, Sundar, Purnima D, Casey, Tyler, Cox, David R, Hauser, Stephen L

“…In multiple sclerosis (MS) pathogenic B cells likely act on both sides of the blood-brain barrier (BBB). However, it is unclear whether antigen-experienced B…”
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Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation by Glanville, Jacob, Kuo, Tracy C., von Büdingen, H.-Christian, Guey, Lin, Berka, Jan, Sundar, Purnima D., Huerta, Gabriella, Mehta, Gautam R., Oksenberg, Jorge R., Hauser, Stephen L., Cox, David R., Rajpal, Arvind, Pons, Jaume

“…A diverse antibody repertoire is essential for an effective adaptive immune response to novel molecular surfaces. Although past studies have observed common…”
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Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire by Yeung, Yik Andy, Foletti, Davide, Deng, Xiaodi, Abdiche, Yasmina, Strop, Pavel, Glanville, Jacob, Pitts, Steven, Lindquist, Kevin, Sundar, Purnima D., Sirota, Marina, Hasa-Moreno, Adela, Pham, Amber, Melton Witt, Jody, Ni, Irene, Pons, Jaume, Shelton, David, Rajpal, Arvind, Chaparro-Riggers, Javier

“…Staphylococcus aureus is both an important pathogen and a human commensal. To explore this ambivalent relationship between host and microbe, we analysed the…”
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Synthetic Antibodies Designed on Natural Sequence Landscapes by Zhai, Wenwu, Glanville, Jacob, Fuhrmann, Markus, Mei, Li, Ni, Irene, Sundar, Purnima D., Van Blarcom, Thomas, Abdiche, Yasmina, Lindquist, Kevin, Strohner, Ralf, Telman, Dilduz, Cappuccilli, Guido, Finlay, William J.J., Van den Brulle, Jan, Cox, David R., Pons, Jaume, Rajpal, Arvind

“…We present a method for synthetic antibody library generation that combines the use of high-throughput immune repertoire analysis and a novel synthetic…”
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