Search Results - "Sunavala, G."

Radioactive iodine: An unappreciated threat to salivary gland function by Sunavala‐Dossabhoy, G

“…Thyroid cancer is an endocrine malignancy whose prevalence is increasing in the United States. Nearly 57,000 new cases of thyroid cancer are estimated to be…”
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Preserving salivary gland physiology against genotoxic damage ‐ the Tousled way by Sunavala‐Dossabhoy, G

“…Tousled and its homologs are evolutionarily conserved serine/threonine kinases present in plants and animals. Human Tousled‐like kinases, TLK1 and TLK2, are…”
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Histopathologic grading of oral mucositis by Sunavala-Dossabhoy, G, Abreo, F, Timiri Shanmugam, PS, Caldito, G

“…Objective Oral mucositis is a common adverse effect of cytotoxic chemotherapy and radiation, and it causes debilitating morbidity that may necessitate…”
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Gene Expression Patterns of Murine Dentin Matrix Protein 1 (Dmp1) and Dentin Sialophosphoprotein (DSPP) Suggest Distinct Developmental Functions In Vivo by D'souza, R. N., Cavender, A., Sunavala, G., Alvarez, J., Ohshima, T., Kulkarni, A. B., MacDougall, M.

“…Although the precise mechanisms of the conversion of predentin to dentin are not well understood, several lines of evidence implicate the noncollagenous…”
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Rapid kinetics of second messenger production in bitter taste by Spielman, A I, Nagai, H, Sunavala, G, Dasso, M, Breer, H, Boekhoff, I, Huque, T, Whitney, G, Brand, J G

“…The tasting of bitter compounds may have evolved as a protective mechanism against ingestion of potentially harmful substances. We have identified second…”
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Adenoviral delivery of Tousled kinase for the protection of salivary glands against ionizing radiation damage by Palaniyandi, S, Odaka, Y, Green, W, Abreo, F, Caldito, G, Benedetti, A De, Sunavala-Dossabhoy, G

“…Oral complications of salivary hypofunction often afflict cancer patients undergoing radiotherapy for head and neck cancers. Dry mouth or xerostomia is an…”
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Regulation of extracellular calcium sensing in rat osteoclasts by femtomolar calcitonin concentrations by Zaidi, M, Shankar, V S, Adebanjo, O A, Lai, F A, Pazianas, M, Sunavala, G, Spielman, A I, Rifkin, B R

“…Certain eukaryotic cells can sense changes in their extracellular Ca2+ concentration through molecular structures termed Ca(2+)-sensing receptors (CaRs). We…”
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A translationally regulated Tousled kinase phosphorylates histone H3 and confers radioresistance when overexpressed by YUAN LI, DEFATTA, Robert, ANTHONY, Charles, SUNAVALA, Gulshan, DE BENEDETTI, Arrigo

“…The gene Tousled of Arabidopsis Thaliana encodes a protein kinase which, when mutated, results in abnormal flower development. From a library of mRNAs that are…”
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Tousled homolog, TLK1, binds and phosphorylates Rad9; TLK1 acts as a molecular chaperone in DNA repair by Sunavala-Dossabhoy, Gulshan, De Benedetti, Arrigo

“…The Tousled-like kinases are involved in chromatin assembly, DNA repair, transcription, and chromosome segregation. In this work, we show that overexpression…”
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Bitter taste transduced by PLC-beta(2)-dependent rise in IP(3) and alpha-gustducin-dependent fall in cyclic nucleotides by Yan, W, Sunavala, G, Rosenzweig, S, Dasso, M, Brand, J G, Spielman, A I

“…Current evidence points to the existence of multiple processes for bitter taste transduction. Previous work demonstrated involvement of the…”
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Translation of the radioresistance kinase TLK1B is induced by gamma-irradiation through activation of mTOR and phosphorylation of 4E-BP1 by Sunavala-Dossabhoy, Gulshan, Fowler, Marcie, De Benedetti, Arrigo

“…The mammalian protein kinase TLK1 is a homologue of Tousled, a gene involved in flower development in Arabidopsis thaliana. The function of TLK1 is not well…”
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Combinatorial Identification of a Novel Consensus Sequence for the Covalent DNA-Binding Polyamide Tallimustine by Sunavala-Dossabhoy, G, Van Dyke, MW

“…Many agents successfully used in cancer chemotherapy either directly or indirectly covalently modify DNA. Examples include cisplatin, which forms a covalent…”
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The radioresistance kinase TLK1B protects the cells by promoting repair of double strand breaks by Sunavala-Dossabhoy, Gulshan, Balakrishnan, Sri Kripa, Sen, Siddhartha, Nuthalapaty, Sam, De Benedetti, Arrigo

“…The mammalian protein kinase TLK1 is a homologue of Tousled, a gene involved in flower development in Arabidopsis thaliana. The function of TLK1 is not well…”
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Combinatorial Identification of a Novel Consensus Sequence for the Covalent DNA-Binding Polyamide Tallimustine by Sunavala-Dossabhoy, Gulshan, Van Dyke, Michael W

“…Many agents successfully used in cancer chemotherapy either directly or indirectly covalently modify DNA. Examples include cisplatin, which forms a covalent…”
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Identification and immunohistochemical localization of protein precursors to human axillary odors in apocrine glands and secretions by Spielman, A I, Sunavala, G, Harmony, J A, Stuart, W D, Leyden, J J, Turner, G, Vowels, B R, Lam, W C, Yang, S, Preti, G

“…To determine the cellular localization in male and female axillary tissue for apocrine secretion odor-binding proteins 1 (ASOB1) and 2 (ASOB2) and the…”
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A dominant negative mutant of TLK1 causes chromosome missegregation and aneuploidy in normal breast epithelial cells by Sunavala-Dossabhoy, Gulshan, Li, Yuan, Williams, Briana, De Benedetti, Arrigo

“…In Arabidopsis thaliana, the gene Tousled encodes a protein kinase of unknown function, but mutations in the gene lead to flowering and leaf morphology…”
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