Search Results - "Sunami, Akihiko"

Mexiletine Block of Voltage-Gated Sodium Channels: Isoform- and State-Dependent Drug-Pore Interactions by Nakagawa, Hiroki, Munakata, Tatsuo, Sunami, Akihiko

“…Mexiletine is a class Ib antiarrhythmic drug and is also used clinically to reduce or prevent myotonia. In addition, mexiletine has neuroprotective effects in…”
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Drug-Binding Sites of Cardiac Sodium Channel by Sunami, Akihiko

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Electrophysiological effects of ginseng and ginsenoside Re in guinea pig ventricular myocytes by Bai, Chang-Xi, Sunami, Akihiko, Namiki, Takao, Sawanobori, Tohru, Furukawa, Tetsushi

“…Panax ginseng is a folk medicine with various cardiovascular actions; however, its underlying mechanisms of action are not well known. In the present study, we…”
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Accessibility of mid-segment domain IV S6 residues of the voltage-gated Na+ channel to methanethiosulfonate reagents by Sunami, Akihiko, Tracey, Arlene, Glaaser, Ian W., Lipkind, Gregory M., Hanck, Dorothy A., Fozzard, Harry A.

“…The inner pore of the voltage-gated Na + channel is predicted by the structure of bacterial potassium channels to be lined with the four S6 α-helical…”
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Sodium Channel Selectivity Filter Regulates Antiarrhythmic Drug Binding by Sunami, Akihiko, Dudley, Samuel C., Fozzard, Harry A.

“…Local anesthetic antiarrhythmic drugs block Na+channels and have important clinical uses. However, the molecular mechanism by which these drugs block the…”
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A Critical Residue for Isoform Difference in Tetrodotoxin Affinity Is a Molecular Determinant of the External Access Path for Local Anesthetics in the Cardiac Sodium Channel by Sunami, Akihiko, Glaaser, Ian W., Fozzard, Harry A.

“…Membrane-impermeant quaternary derivatives of lidocaine (QX222 and QX314) block cardiac Na+channels when applied from either side of the membrane, but they…”
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Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access by Sasaki, Koji, Makita, Naomasa, Sunami, Akihiko, Sakurada, Harumizu, Shirai, Nobumasa, Yokoi, Hisataka, Kimura, Akinori, Tohse, Noritsugu, Hiraoka, Masayasu, Kitabatake, Akira

“…Gating properties of Na(+) channels are the critical determinants for the state-dependent block by class I antiarrhythmic drugs; however, recent site-directed…”
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Structural and gating changes of the sodium channel induced by mutation of a residue in the upper third of IVS6, creating an external access path for local anesthetics by Sunami, A, Glaaser, I W, Fozzard, H A

“…Membrane-impermeant quaternary amine local anesthetics QX314 and QX222 can access their binding site on the cytoplasmic side of the selectivity filter from the…”
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The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome by Makita, Naomasa, Behr, Elijah, Shimizu, Wataru, Horie, Minoru, Sunami, Akihiko, Crotti, Lia, Schulze-Bahr, Eric, Fukuhara, Shigetomo, Mochizuki, Naoki, Makiyama, Takeru, Itoh, Hideki, Christiansen, Michael, McKeown, Pascal, Miyamoto, Koji, Kamakura, Shiro, Tsutsui, Hiroyuki, Schwartz, Peter J, George, Jr, Alfred L, Roden, Dan M

“…Phenotypic overlap of type 3 long QT syndrome (LQT3) with Brugada syndrome (BrS) is observed in some carriers of mutations in the Na channel SCN5A. While this…”
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A Genetically Encoded Bioluminescent Indicator for the Sodium Channel Activity in Living Cells by Kaihara, Asami, Sunami, Akihiko, Kurokawa, Junko, Furukawa, Tetsushi

“…We have developed a genetically encoded bioluminescent indicator for the Na+ channel, in which Na+-sensitive Gaussia luciferase is fused with the voltage-gated…”
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Role of L1462 in Nav1.5 Channel DIII-S6 in Voltage-dependent Gating and Antiarrhythmic Block by Katayama, Nao, Konno, Keiichi, Kawakubo, Atsushi, Ishimaru, Naoki, Sunami, Akihiko

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New observations on the mechanisms of antiarrhythmic actions of disopyramide on cardiac membranes by Hiraoka, Masayasu, Kuga, Keisuke, Kawano, Seiko, Sunami, Akihiko, Fan, Zhen

“…Electrophysiologic effects of disopyramide on cardiac membranes were studied using the microelectrode technique applied to papillary muscles and the suction…”
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Electrophysiological properties of a new antiarrhythmic agent, bisaramil on guinea-pig, rabbit and canine cardiac preparations by Sunami, A, Sawanobori, T, Adaniya, H, Hiraoka, M

“…Electrophysiological effects of bisaramil, a novel antiarrhythmic agent, were examined using the conventional microelectrode technique applied to cardiac…”
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Synthesis and Biological Activity of the Metabolites of syn-3-Ethyl-7-methyl-3, 7-diazabicyclo[3.3.1]non-9-yl 4-Chlorobenzoate Hydrochloride by YAMAWAKI, Ichiro, BUKOVAC, Scott W., SUNAMI, Akihiko

“…Five metabolites of syn-3-ethyl-7-methyl-3, 7-diazabicyclo[3.3.1]non-9-yl 4-chlorobenzoate hydrochloride (YUTAC)(1) were prepared and examined for Na+ current…”
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Combined effects of different class I antiarrhythmic agents on maximum rate of depolarization (V max ) of action potentials in guinea-gig papillary muscles by Hiraoka, Masayasu, Nitta, Jun-ichi, Sunami, Akihiko, Sawanobori, Tohru

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Accessibility of mid-segment domain IV S6 residues of the voltage-gated Na super(+) channel to methanethiosulfonate reagents by Sunami, Akihiko, Tracey, Arlene, Glaaser, Ian W, Lipkind, Gregory M, Hanck, Dorothy A, Fozzard, Harry A

“…The inner pore of the voltage-gated Na super(+) channel is predicted by the structure of bacterial potassium channels to be lined with the four S6 alpha-…”
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Involvement of local anesthetic binding sites on IVS6 of sodium channels in fast and slow inactivation by Bai, Chang-Xi, Glaaser, Ian W., Sawanobori, Tohru, Sunami, Akihiko

“…Local anesthetics (LAs) block Na + channels with a higher affinity for the fast or slow inactivated state of the channel. Their binding to the channel may…”
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Cardiac-Specific External Paths for Lidocaine, Defined by Isoform-Specific Residues, Accelerate Recovery From Use-Dependent Block by Lee, Peter J, Sunami, Akihiko, Fozzard, Harry A

“…Local anesthetic antiarrhythmic drugs block voltage-gated Na channels from the cytoplasmic side. In addition, cardiac Na channels can be also blocked by the…”
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Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug. (2). Analgesic and antipyretic effects by Ono, N, Sunami, A, Yamamoto, N, Yamasaki, Y, Miyake, H

“…Analgesic and antipyretic effects of proglumetacin maleate (PGM), a new indomethacin (IND) derivative, were investigated in comparison with those of IND on an…”
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Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug. (1). Anti-inflammatory effects by Ono, N, Yamamoto, N, Sunami, A, Yamasaki, Y, Miyake, H

“…Anti-inflammatory effects of proglumetacin maleate (PGM), a new indomethacin (IND) derivative, were compared with those of IND on an equimolar-dose basis. PGM…”
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