Search Results - "Sun, Xingshen"

Highly Efficient Transgenesis in Ferrets Using CRISPR/Cas9-Mediated Homology-Independent Insertion at the ROSA26 Locus by Yu, Miao, Sun, Xingshen, Tyler, Scott R., Liang, Bo, Swatek, Anthony M., Lynch, Thomas J., He, Nan, Yuan, Feng, Feng, Zehua, Rotti, Pavana G., Choi, Soon H., Shahin, Weam, Liu, Xiaoming, Yan, Ziying, Engelhardt, John F.

“…The domestic ferret ( Mustela putorius furo ) has proven to be a useful species for modeling human genetic and infectious diseases of the lung and brain…”
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Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis by Sun, Xingshen, Sui, Hongshu, Fisher, John T, Yan, Ziying, Liu, Xiaoming, Cho, Hyung-Ju, Joo, Nam Soo, Zhang, Yulong, Zhou, Weihong, Yi, Yaling, Kinyon, Joann M, Lei-Butters, Diana C, Griffin, Michelle A, Naumann, Paul, Luo, Meihui, Ascher, Jill, Wang, Kai, Frana, Timothy, Wine, Jeffrey J, Meyerholz, David K, Engelhardt, John F

“…Cystic fibrosis (CF) is a recessive disease that affects multiple organs. It is caused by mutations in CFTR. Animal modeling of this disease has been…”
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PyMINEr Finds Gene and Autocrine-Paracrine Networks from Human Islet scRNA-Seq by Tyler, Scott R., Rotti, Pavana G., Sun, Xingshen, Yi, Yaling, Xie, Weiliang, Winter, Michael C., Flamme-Wiese, Miles J., Tucker, Budd A., Mullins, Robert F., Norris, Andrew W., Engelhardt, John F.

“…Toolsets available for in-depth analysis of scRNA-seq datasets by biologists with little informatics experience is limited. Here, we describe an informatics…”
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Derivation of induced pluripotent stem cells from ferret somatic cells by Gao, Jinghui, Petraki, Sophia, Sun, Xingshen, Brooks, Leonard A, Lynch, Thomas J, Hsieh, Chih-Lin, Elteriefi, Reem, Lorenzana, Zareeb, Punj, Vasu, Engelhardt, John F, Parekh, Kalpaj R, Ryan, Amy L

“…Ferrets are an attractive mammalian model for several diseases, especially those affecting the lungs, liver, brain, and kidneys. Many chronic human diseases…”
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Adeno-associated virus-targeted disruption of the CFTR gene in cloned ferrets by Sun, Xingshen, Yan, Ziying, Yi, Yaling, Li, Ziyi, Lei, Diana, Rogers, Christopher S, Chen, Juan, Zhang, Yulong, Welsh, Michael J, Leno, Gregory H, Engelhardt, John F

“…Somatic cell gene targeting combined with nuclear transfer cloning presents tremendous potential for the creation of new, large-animal models of human…”
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A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse by Nakano, Yoko, Jahan, Israt, Bonde, Gregory, Sun, Xingshen, Hildebrand, Michael S, Engelhardt, John F, Smith, Richard J H, Cornell, Robert A, Fritzsch, Bernd, Bánfi, Botond

“…Sensory hair cells are essential for hearing and balance. Their development from epithelial precursors has been extensively characterized with respect to…”
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Repeat Dosing of AAV2.5T to Ferret Lungs Elicits an Antibody Response That Diminishes Transduction in an Age-Dependent Manner by Tang, Yinghua, Yan, Ziying, Lin, Shen, Huntemann, Eric D., Feng, Zehua, Park, Soo-Yeun, Sun, Xingshen, Yuen, Eric, Engelhardt, John F.

“…Readministration of recombinant adeno-associated virus (rAAV) may be necessary to treat cystic fibrosis (CF) lung disease using gene therapy. However, little…”
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Ferret models of alpha-1 antitrypsin deficiency develop lung and liver disease by He, Nan, Liu, Xiaoming, Vegter, Amber R, Evans, T Idil A, Gray, Jaimie S, Guo, Junfeng, Moll, Shashanna R, Guo, Lydia J, Luo, Meihui, Ma, Ningxia, Sun, Xingshen, Liang, Bo, Yan, Ziying, Feng, Zehua, Qi, Lisi, Joshi, Arnav S, Shahin, Weam, Yi, Yaling, Gibson-Corley, Katherine N, Hoffman, Eric A, Wang, Kai, Mueller, Christian, Engelhardt, John F, Rosen, Bradley H

“…Alpha-1 antitrypsin deficiency (AATD) is the most common genetic cause and risk factor for chronic obstructive pulmonary disease, but the field lacks a…”
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Oxidative stress and impaired insulin secretion in cystic fibrosis pig pancreas by O'Malley, Yunxia, Coleman, Mitchell C., Sun, Xingshen, Lei, Junying, Yao, Jianrong, Pulliam, Casey F., Kluz, Paige, McCormick, Michael L., Yi, Yaling, Imai, Yumi, Engelhardt, John F., Norris, Andrew W., Spitz, Douglas R., Uc, Aliye

“…•Pancreatic CuZnSOD activity and glutathione levels are significantly diminished, oxidatively modified proteins are upregulated in a well-established cystic…”
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Quantifying insulin sensitivity and entero-insular responsiveness to hyper- and hypoglycemia in ferrets by Sui, Hongshu, Yi, Yaling, Yao, Jianrong, Liang, Bo, Sun, Xingshen, Hu, Shanming, Uc, Aliye, Nelson, Deborah J, Ode, Katie Larson, Philipson, Louis H, Engelhardt, John F, Norris, Andrew W

“…Ferrets are an important emerging model of cystic fibrosis related diabetes. However, there is little documented experience in the use of advanced techniques…”
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Efficient Term Development of Vitrified Ferret Embryos Using a Novel Pipette Chamber Technique by Sun, Xingshen, Li, Ziyi, Yi, Yaling, Chen, Juan, Leno, Gregory H, Engelhardt, John F

“…Development of an efficient cryopreservation technique for the domestic ferret is key for the long-term maintenance of valuable genetic specimens of this…”
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A biomass-rich, self-healable, and high-adhesive polymer binder for advanced lithium-sulfur batteries by Wen, Yong, Lin, Xiangyu, Sun, Xingshen, Wang, Shanshan, Wang, Jie, Liu, He, Xu, Xu

“…[Display omitted] Although lithium-sulfur (Li-S) batteries have attracted a great deal of attention due to their ultrahigh energy density, the significant…”
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Explainable fault diagnosis of oil-gas treatment station based on transfer learning by Liu, Jiaquan, Hou, Lei, Zhang, Rui, Sun, Xingshen, Yu, Qiaoyan, Yang, Kai, Zhang, Xinru

“…Fault diagnosis is crucial for safe operation of the oil-gas treatment station. With the rapid-increasing volume of the data collected in oil-gas fields, more…”
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Research on Apparent Viscosity Variation of Water-in-Oil Waxy Crude Oil Emulsions Induced by a Magnetic Field by Zhu, Zuoliang, Hou, Lei, Zhang, Xinru, Liu, Jiaquan, Sun, Xingshen, Xiong, Yifan

“…The formation of water-in-oil waxy crude oil emulsions deteriorates the rheological properties of the oil–water mixture. Magnetic treatment technology is an…”
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Removal mechanism of adhering heavy oil from pipeline wall in low-temperature flow by Sun, Xingshen, Hou, Lei, Tang, Shuaishuai, Wang, Mincong, Xiong, Yifan, Zhu, Zuoliang

“…With the global emphasis on heavy oil development and increasing water content in Chinese oilfields, the low-temperature flow of heavy oil has been widely…”
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Advanced-design cross-linked binder enables high-performance silicon-based anodes through in-situ crosslinking based on sodium carboxymethyl cellulose and poly-lysine by Sun, Xingshen, Lin, Xiangyu, Dong, Fuhao, Shen, Minggui, Liu, He, Song, Zhanqian, Jiang, Jianxin

“…Practical employment of silicon (Si) electrodes in lithium-ion batteries (LIBs) is limited due to the severe volume changes suffered during…”
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A novel [1,2,4]triazolo[1,5-a]pyrimidine derivative as a fluorescence probe for specific detection of Fe3+ ions and application in cell imaging by Geng, Yanru, Chen, Liping, Wan, Qinglan, Lian, Chengxi, Han, Yu, Wang, Yan, Zhang, Chaoying, Huang, Longjiang, Zhao, Han, Sun, Xingshen, He, Hongwei

“…The detection of metal ions is of particular importance for monitoring environmental pollution and life metabolic activities. However, it is still a challenge…”
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Effect of magnetic field on the apparent viscosity of water-in-oil waxy crude oil emulsion by Zhu, Zuoliang, Hou, Lei, Zhang, Xinru, Liu, Jiaquan, Sun, Xingshen, Xiong, Yifan

“…•Viscosity reduction effect is more obvious for emulsions with higher water cuts.•Treatment time and field frequency have weak effects on the emulsion…”
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Explainable fault diagnosis of gas-liquid separator based on fully convolutional neural network by Liu, Jiaquan, Hou, Lei, Wang, Xin, Zhang, Rui, Sun, Xingshen, Xu, Lei, Yu, Qiaoyan

“…•An explainable diagnosis network based on FCN is designed for gas-liquid separator.•The class activation mapping is considered to ensure the explainability of…”
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Abnormal Glucose Tolerance in Infants and Young Children with Cystic Fibrosis by Yi, Yaling, Norris, Andrew W, Wang, Kai, Sun, Xingshen, Uc, Aliye, Moran, Antoinette, Engelhardt, John F, Ode, Katie Larson

“…In cystic fibrosis, abnormal glucose tolerance is associated with decreased lung function and worsened outcomes. Translational evidence indicates that abnormal…”
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