Search Results - "Sun, Sophie"

A Versatile Platform for Single- and Multiple-Unnatural Amino Acid Mutagenesis in Escherichia coli by Chatterjee, Abhishek, Sun, Sophie B, Furman, Jennifer L, Xiao, Han, Schultz, Peter G

“…To site-specifically incorporate an unnatural amino acid (UAA) into target proteins in Escherichia coli, we use a suppressor plasmid that provides an…”
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Versatile strategy for controlling the specificity and activity of engineered T cells by Ma, Jennifer S. Y., Kim, Ji Young, Kazane, Stephanie A., Choi, Sei-hyun, Yun, Hwa Young, Kim, Min Soo, Rodgers, David T., Pugh, Holly M., Singer, Oded, Sun, Sophie B., Fonslow, Bryan R., Kochenderfer, James N., Wright, Timothy M., Schultz, Peter G., Young, Travis S., Kim, Chan Hyuk, Cao, Yu

“…The adoptive transfer of autologous T cells engineered to express a chimeric antigen receptor (CAR) has emerged as a promising cancer therapy. Despite…”
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Upper bounds of dual flagged Weyl characters by Peng, Simon C.Y., Lin, Zhuowei, Sun, Sophie C.C.

“…For a subset D of boxes in an n×n square grid, let χD(x) denote the dual character of the flagged Weyl module associated to D. It is known that χD(x) specifies…”
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A Genetically Encoded aza-Michael Acceptor for Covalent Cross-Linking of Protein–Receptor Complexes by Furman, Jennifer L, Kang, Mingchao, Choi, Seihyun, Cao, Yu, Wold, Erik D, Sun, Sophie B, Smider, Vaughn V, Schultz, Peter G, Kim, Chan Hyuk

“…Selective covalent bond formation at a protein–protein interface potentially can be achieved by genetically introducing into a protein an appropriately “tuned”…”
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Hallmarks of Aging in the Liver by Hunt, Nicholas J., Kang, Sun Woo (Sophie), Lockwood, Glen P., Le Couteur, David G., Cogger, Victoria C.

“…While the liver demonstrates remarkable resilience during aging, there is growing evidence that it undergoes all the cellular hallmarks of aging, which…”
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New insights into the biology and development of lung cancer in never smokers-implications for early detection and treatment by Wang, Peiyao, Sun, Sophie, Lam, Stephen, Lockwood, William W

“…Lung cancer is the leading cause of cancer deaths worldwide. Despite never smokers comprising between 10 and 25% of all cases, lung cancer in never smokers…”
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New molecularly targeted therapies for lung cancer by Sun, Sophie, Schiller, Joan H, Spinola, Monica, Minna, John D

“…Lung cancer is the leading cause of cancer death worldwide. The disease is particularly difficult to detect, and patients often present at an advanced stage…”
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Therapeutic Applications of an Expanded Genetic Code by Sun, Sophie B., Schultz, Peter G., Kim, Chan Hyuk

“…To date, over 100 noncanonical amino acids (ncAAs) have been genetically encoded in living cells in order to expand the functional repertoire of the canonical…”
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The Effects of Metformin on Age-Related Changes in the Liver Sinusoidal Endothelial Cell by Hunt, Nicholas J, Lockwood, Glen P, Kang, Sun Woo (Sophie), Pulpitel, Tamara, Clark, Ximonie, Mao, Hong, McCourt, Peter A G, Cooney, Gregory J, Wali, Jibran A, Le Couteur, Frank H, Le Couteur, David G, Cogger, Victoria C

“…Abstract Age-related changes in the liver sinusoidal endothelium, particularly the reduction in fenestrations, contribute to insulin resistance in old age…”
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Genetic testing for hereditary cancer syndromes: patient recommendations for improved risk communication by Pollard, Samantha, Kalloger, Steve, Weymann, Deirdre, Sun, Sophie, Nuk, Jennifer, Schrader, Kasmintan A., Regier, Dean A.

“…Background Multi‐gene panel testing is replacing single‐gene testing for patients with suspected hereditary cancer syndromes. The detection of a hereditary…”
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Improved structural variant interpretation for hereditary cancer susceptibility using long-read sequencing by Thibodeau, My Linh, O’Neill, Kieran, Dixon, Katherine, Reisle, Caralyn, Mungall, Karen L., Krzywinski, Martin, Shen, Yaoqing, Lim, Howard J., Cheng, Dean, Tse, Kane, Wong, Tina, Chuah, Eric, Fok, Alexandra, Sun, Sophie, Renouf, Daniel, Schaeffer, David F., Cremin, Carol, Chia, Stephen, Young, Sean, Pandoh, Pawan, Pleasance, Stephen, Pleasance, Erin, Mungall, Andrew J., Moore, Richard, Yip, Stephen, Karsan, Aly, Laskin, Janessa, Marra, Marco A., Schrader, Kasmintan A., Jones, Steven J. M.

“…Purpose Structural variants (SVs) may be an underestimated cause of hereditary cancer syndromes given the current limitations of short-read next-generation…”
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Real-World Clinical Outcomes for Patients with EGFR and HER2 Exon 20 Insertion-Mutated Non-Small-Cell Lung Cancer by Li, Kelly, Bosdet, Ian, Yip, Stephen, Ho, Cheryl, Laskin, Janessa, Melosky, Barbara, Wang, Ying, Sun, Sophie

“…(1) Background: Exon 20 insertion mutations (ex20ins) in and are uncommon driver mutations in non-small-cell lung cancer (NSCLC), with a poor prognosis and few…”
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Development and early‐stage evaluation of a patient portal to enhance familial communication about hereditary cancer susceptibility testing: A patient‐driven approach by Pollard, Samantha, Weymann, Deirdre, Loewen, Rosalie, Nuk, Jennifer, Sun, Sophie, Schrader, Kasmintan A., Hessels, Chiquita, Regier, Dean A.

“…Introduction Genetic testing for hereditary cancer syndromes (HCSs) can improve health outcomes through cancer risk mitigation strategies. Effective…”
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Retraction of “Mutational Analysis of 48G7 Reveals that Somatic Hypermutation Affects Both Antibody Stability and Binding Affinity” by Sun, Sophie B, Sen, Shiladitya, Kim, Nam-Jung, Magliery, Thomas J, Schultz, Peter G, Wang, Feng

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Beyond PACIFIC: Real-World Outcomes of Adjuvant Durvalumab According to Treatment Received and PD-L1 Expression by Denault, Marie-Hélène, Feng, Jamie, Kuang, Shelley, Shokoohi, Aria, Leung, Bonnie, Liu, Mitchell, Berthelet, Eric, Laskin, Janessa, Sun, Sophie, Zhang, Tina, Ho, Cheryl, Melosky, Barbara

“…Adjuvant durvalumab after chemoradiotherapy (CRT) is the standard of care for unresectable stage III non-small cell lung cancer (NSCLC). A post hoc exploratory…”
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Less toxic chemotherapy improves uptake of all lines of chemotherapy in advanced non-small-cell lung cancer: a 10-year retrospective population-based review by Ho, Cheryl, Ramsden, Katherine, Zhai, Yongliang, Murray, Nevin, Sun, Sophie, Melosky, Barbara, Laskin, Janessa

“…Over the past decade, well tolerated second-line therapies for advanced non-small-cell lung cancer have been approved including erlotinib and pemetrexed in…”
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Knowledge Workers, Identities, and Communication Practices: Understanding Code Farmers in China by Sun Ping, Sophie, Magasic, Michelangelo

“…Extending the concept of “knowledge workers”, this paper studies the identity dynamics of IT programmers from small companies in China. Through the discursive…”
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Disparate Time-to-Treatment and Varied Incidence of Actionable Non-Small Cell Lung Cancer Molecular Alterations in British Columbia: A Historical Cohort Study by Hilzenrat, Roy Avraham, Yip, Stephen, Melosky, Barbara, Ho, Cheryl, Laskin, Janessa, Sun, Sophie, Choi, James J, McGuire, Anna L

“…Background: non-small cell lung cancer (NSCLC) outcomes remain suboptimal for early-stage disease despite emerging advances in systemic therapy for the…”
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Mutational Analysis of 48G7 Reveals that Somatic Hypermutation Affects Both Antibody Stability and Binding Affinity by Sun, Sophie B, Sen, Shiladitya, Kim, Nam-Jung, Magliery, Thomas J, Schultz, Peter G, Wang, Feng

“…The monoclonal antibody 48G7 differs from its germline precursor by 10 somatic mutations, a number of which appear to be functionally silent. We analyzed the…”
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P076: Implementing tumor-first genetic testing and parent-of-origin-aware genomic analysis into the diagnostic pipeline for hereditary breast cancer by Huang, Haojun, Fok, Alexandra, Tucker, Tracy, Yip, Stephen, Kos, Zuzana, Mar, Colin, Sun, Sophie, Schrader, Kasmintan

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