Search Results - "Sun, Ryan"

Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity by Hildreth, Andrew D., Ma, Feiyang, Wong, Yung Yu, Sun, Ryan, Pellegrini, Matteo, O’Sullivan, Timothy E.

“…White adipose tissue (WAT) is an essential regulator of energy storage and systemic metabolic homeostasis. Regulatory networks consisting of immune and…”
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Influence of musical background on surgical skills acquisition by Sun, Ryan R., Wang, Yushi, Fast, Andrew, Dutka, Chris, Cadogan, Kianna, Burton, Lauren, Kubay, Cole, Drachenberg, Darrel

“…There is growing interest in identifying trainees with surgical aptitude predictive of eventual technical proficiency. Musical tasks involve complex, cerebral…”
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Powerful gene set analysis in GWAS with the Generalized Berk-Jones statistic by Sun, Ryan, Hui, Shirley, Bader, Gary D, Lin, Xihong, Kraft, Peter

“…A common complementary strategy in Genome-Wide Association Studies (GWAS) is to perform Gene Set Analysis (GSA), which tests for the association between one…”
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9p21 loss confers a cold tumor immune microenvironment and primary resistance to immune checkpoint therapy by Han, Guangchun, Yang, Guoliang, Hao, Dapeng, Lu, Yang, Thein, Kyaw, Simpson, Benjamin S., Chen, Jianfeng, Sun, Ryan, Alhalabi, Omar, Wang, Ruiping, Dang, Minghao, Dai, Enyu, Zhang, Shaojun, Nie, Fengqi, Zhao, Shuangtao, Guo, Charles, Hamza, Ameer, Czerniak, Bogdan, Cheng, Chao, Siefker-Radtke, Arlene, Bhat, Krishna, Futreal, Andrew, Peng, Guang, Wargo, Jennifer, Peng, Weiyi, Kadara, Humam, Ajani, Jaffer, Swanton, Charles, Litchfield, Kevin, Ahnert, Jordi Rodon, Gao, Jianjun, Wang, Linghua

“…Immune checkpoint therapy (ICT) provides substantial clinical benefits to cancer patients, but a large proportion of cancers do not respond to ICT. To date,…”
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Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis by Han, Younghun, Byun, Jinyoung, Zhu, Catherine, Sun, Ryan, Roh, Julia Y., Cordell, Heather J., Lee, Hyun-Sung, Shaw, Vikram R., Kang, Sung Wook, Razjouyan, Javad, Cooley, Matthew A., Hassan, Manal M., Siminovitch, Katherine A., Folseraas, Trine, Ellinghaus, David, Bergquist, Annika, Rushbrook, Simon M., Franke, Andre, Karlsen, Tom H., Lazaridis, Konstantinos N., McGlynn, Katherine A., Roberts, Lewis R., Amos, Christopher I.

“…Primary sclerosing cholangitis (PSC) is a rare autoimmune bile duct disease that is strongly associated with immune-mediated disorders. In this study, we…”
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Development of therapeutic microbubbles for enhancing ultrasound-mediated gene delivery by Sun, Ryan R., Noble, Misty L., Sun, Samuel S., Song, Shuxian, Miao, Carol H.

“…Ultrasound (US)-mediated gene delivery has emerged as a promising non-viral method for safe and selective gene delivery. When enhanced by the cavitation of…”
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The validation of elastic modulus models: Code models and their modified versions by Sun, Ryan W., Fanourakis, George C.

“…Elastic modulus (E) estimation forms an important element in the methods used to predict concrete creep deformation, which is an important structural design…”
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Hematopoietic progenitor kinase 1 inhibits the development and progression of pancreatic intraepithelial neoplasia by Wang, Hua, Moniruzzaman, Rohan, Li, Lei, Ji, Baoan, Liu, Yi, Zuo, Xiangsheng, Abbasgholizadeh, Reza, Zhao, Jun, Liu, Guangchao, Wang, Ruiqi, Tang, Hongli, Sun, Ryan, Su, Xiaoping, Tan, Tse-Hua, Maitra, Anirban, Wang, Huamin

“…Ras plays an essential role in the development of acinar-to-ductal metaplasia (ADM) and pancreatic ductal adenocarcinoma (PDAC). However, mutant Kras is an…”
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Testing for Gene–Environment Interaction Under Exposure Misspecification by Sun, Ryan, Carroll, Raymond J., Christiani, David C., Lin, Xihong

“…Complex interplay between genetic and environmental factors characterizes the etiology of many diseases. Modeling gene-environment (GxE) interactions is often…”
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MicroRNA-124 Reduces Arsenic-induced Endoplasmic Reticulum Stress and Neurotoxicity and is Linked with Neurodevelopment in Children by Park, Hae-Ryung, Sun, Ryan, Panganiban, Ronald A., Christiani, David C., Lu, Quan

“…Arsenic (As) exposure adversely affects neurodevelopment in children. Accumulation of misfolded proteins in cells exposed to As leads to endoplasmic reticulum…”
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CRISPR-Cas9 Ribonucleoprotein-Mediated Genomic Editing in Mature Primary Innate Immune Cells by Riggan, Luke, Hildreth, Andrew D., Rolot, Marion, Wong, Yung-Yu, Satyadi, William, Sun, Ryan, Huerta, Christopher, O’Sullivan, Timothy E.

“…CRISPR genome engineering has become a powerful tool to functionally investigate the complex mechanisms of immune system regulation. While decades of work have…”
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Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk by Gorman, Bryan R., Ji, Sun-Gou, Francis, Michael, Sendamarai, Anoop K., Shi, Yunling, Devineni, Poornima, Saxena, Uma, Partan, Elizabeth, DeVito, Andrea K., Byun, Jinyoung, Han, Younghun, Xiao, Xiangjun, Sin, Don D., Timens, Wim, Moser, Jennifer, Muralidhar, Sumitra, Ramoni, Rachel, Hung, Rayjean J., McKay, James D., Bossé, Yohan, Sun, Ryan, Amos, Christopher I., Pyarajan, Saiju

“…Lung cancer remains the leading cause of cancer mortality, despite declining smoking rates. Previous lung cancer GWAS have identified numerous loci, but…”
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Effect of delayed cell infusion in patients with large B-cell lymphoma treated with chimeric antigen receptor T-cell therapy by Jallouk, Andrew P, Kui, Naishu, Sun, Ryan, Westin, Jason R, Steiner, Raphael E, Nair, Ranjit, Nastoupil, Loretta J, Fayad, Luis E, Zaki, Ajlan Al, Hawkins, Misha, Adkins, Sherry, Noorani, Mansoor, Das, Kaberi, Henderson, Jared, Shpall, Elizabeth J, Kebriaei, Partow, Ramdial, Jeremy, Flowers, Christopher R, Neelapu, Sattva S, Ahmed, Sairah, Strati, Paolo

“…Complications occurring after lymphodepleting chemotherapy (LDC) may delay chimeric antigen receptor (CAR) T-cell infusion. The effect of these delays on…”
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Survival improvement for patients with metastatic colorectal cancer over twenty years by Zeineddine, Fadl A., Zeineddine, Mohammad A., Yousef, Abdelrahman, Gu, Yue, Chowdhury, Saikat, Dasari, Arvind, Huey, Ryan W., Johnson, Benny, Kee, Bryan, Lee, Michael S., Morelli, Maria Pia, Morris, Van K., Overman, Michael J., Parseghian, Christine, Raghav, Kanwal, Willis, Jason, Wolff, Robert A., Kawaguchi, Yoshikuni, Vauthey, Jean-Nicolas, Sun, Ryan, Kopetz, Scott, Shen, John Paul

“…Over the past two decades of successive clinical trials in metastatic colorectal cancer (CRC), the median overall survival of both control and experimental…”
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Factors for poor oral health in long-term childhood cancer survivors by Patni, Tushar, Lee, Chun-Teh, Li, Yimei, Kaste, Sue, Zhu, Liang, Sun, Ryan, Hudson, Melissa M, Ness, Kirsten K, Neumann, Ana, Robison, Leslie L

“…Survivors of childhood cancer are at risk for therapy-related dental diseases. The purpose of the study was to investigate the associations between clinical,…”
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Tumor-induced alterations in lymph node lymph drainage identified by contrast-enhanced MRI by Ruddell, Alanna, Kirschbaum, Sara B., Ganti, Sheila N., Liu, Cheng-Liang, Sun, Ryan R., Partridge, Savannah C.

“…Background To use high resolution MRI lymphography to characterize altered tumor‐draining lymph node (TDLN) lymph drainage in response to growth of aggressive…”
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Chimeric antigen receptor T cells to target CD79b in B-cell lymphomas by Chu, Fuliang, Cao, Jingjing, Liu, Jingwei, Yang, Haopeng, Davis, Timothy J, Kuang, Shao-qing, Cheng, Xiaoyun, Zhang, Zheng, Karri, Swathi, Vien, Long T, Bover, Laura, Sun, Ryan, Vega, Francisco, Green, Michael, Davis, Richard Eric, Neelapu, Sattva S

“…BackgroundChimeric antigen receptor (CAR) T cells targeting CD19 mediate potent and durable effects in B-cell malignancies. However, antigen loss or…”
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Moving beyond conventional stratified analysis to assess the treatment effect in a comparative oncology study by Sun, Ryan, McCaw, Zachary, Tian, Lu, Uno, Hajime, Hong, Fangxin, Kim, Dae Hyun, Wei, Lee-Jen

“…In a comparative oncology study with progression-free or overall survival as the endpoint, the primary or key secondary analysis is routinely stratified by…”
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Natural history and prognostic factors for localised small bowel adenocarcinoma by Colina, Andreina, Hwang, Hyunsoo, Wang, Huamin, Katz, Matthew H G, Sun, Ryan, Lee, Jeffrey E, Thomas, Jane, Tzeng, Ching-Wei, Wolff, Robert A, Raghav, Kanwal, Overman, Michael J

“…ObjectiveSmall bowel adenocarcinoma (SBA) is a rare malignancy with limited evidence regarding outcomes after curative resection of localised disease. We aimed…”
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Circulating Galectin-3: A Prognostic Biomarker in Hepatocellular Carcinoma by Chamseddine, Shadi, Yavuz, Betul Gok, Mohamed, Yehia I., Lee, Sunyoung S., Yao, James C., Hu, Zishuo Ian, LaPelusa, Michael, Xiao, Lianchun, Sun, Ryan, Morris, Jeffrey S., Hatia, Rikita I., Hassan, Manal, Duda, Dan G., Diab, Maria, Mohamed, Amr, Nassar, Ahmed, Amin, Hesham M., Kaseb, Ahmed Omar

“…Introduction Galectin-3 plays critical roles in the adhesion, proliferation, and differentiation of tumor cells. Recent data have suggested that galectin-3…”
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