Search Results - "Sun, Pengling"

MiR-34a, a promising novel biomarker for benzene toxicity, is involved in cell apoptosis triggered by 1,4-benzoquinone through targeting Bcl-2 by Chen, Yujiao, Sun, Pengling, Guo, Xiaoli, Gao, Ai

“…Exposure to benzene is inevitable, and concerns regarding the adverse health effects of benzene have been raised. Most investigators found that benzene…”
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Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats by Zheng, Xingfeng, Mao, Yanfei, Cai, Jianmei, Li, Yonghua, Liu, Wenwu, Sun, Pengling, Zhang, John H, Sun, Xuejun, Yuan, Hongbin

“…Hydrogen gas was reported to reduce reactive oxygen species and alleviate cerebral, myocardial and hepatic ischemia/reperfusion (I/R) injuries. This paper…”
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Marstacimab, a tissue factor pathway inhibitor neutralizing antibody, improves coagulation parameters of ex vivo dosed haemophilic blood and plasmas by Patel‐Hett, Sunita, Martin, Erika J., Mohammed, Bassem M., Rakhe, Swapnil, Sun, Pengling, Barrett, John C., Nolte, Melinda E., Kuhn, Janice, Pittman, Debra D., Murphy, John E., Brophy, Donald F.

“…Introduction Tissue factor pathway inhibitor (TFPI) is an endogenous inhibitor of the extrinsic pathway that negatively regulates thrombin production during…”
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Acid phosphatase 5 is responsible for removing the mannose 6-phosphate recognition marker from lysosomal proteins by Sun, Pengling, Sleat, David E, Lecocq, Michèle, Hayman, Alison R, Jadot, Michel, Lobel, Peter

“…Most newly synthesized proteins destined for the lysosome reach this location via a specific intracellular pathway. In the Golgi, a phosphotransferase…”
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Association of serum levels of perfluoroalkyl substances (PFASs) with the metabolic syndrome (MetS) in Chinese male adults: A cross–sectional study by Yang, Qiaoyun, Guo, Xiaoli, Sun, Pengling, Chen, Yujiao, Zhang, Wei, Gao, Ai

“…As extensively used chemicals in a variety of consumer products, perfluoroalkyl substances (PFASs) are ubiquitous and could bring significant risk to human…”
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Characterizing a Cohort of Patients with Hemophilia B Treated with Fidanacogene Elaparvovec from the Phase 3 Benegene-2 Study Who Returned to Factor IX Prophylaxis by Frenzel, Laurent, Kavakli, Kaan, Klamroth, Robert, Chiou, Shyh-Shin, Shapiro, Amy D., Sun, Pengling, Fuiman, Joanne, McKay, John, Fang, Annie F., Biondo, Francesca, Plonski, Frank, Rupon, Jeremy

“…Background: Fidanacogene elaparvovec (PF-06838435, formerly SPK-9001) is an adeno-associated virus (AAV)-based gene therapy designed to deliver a high-activity…”
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A Phase I Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Dopamine D1 Receptor Partial Agonist, PF-06669571, in Subjects with Idiopathic Parkinson’s Disease by Gurrell, Rachel, Duvvuri, Sridhar, Sun, Pengling, DeMartinis, Nicholas

“…Background and Objectives There is an unmet medical need for additional treatment options for Parkinson’s disease. This was a Phase I, double-blind clinical…”
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VNN3, a potential novel biomarker for benzene toxicity, is involved in 1, 4-benzoquinone induced cell proliferation by Sun, Pengling, Guo, Xiaoli, Chen, Yujiao, Zhang, Wei, Duan, Huawei, Gao, Ai

“…Benzene is widely employed in the field of production, and its toxicity on biological systems has received increasing attention. Cell proliferation is a major…”
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A phase 1b/2 clinical study of marstacimab, targeting human tissue factor pathway inhibitor, in haemophilia by Mahlangu, Johnny N., Lamas, Jose Luis, Morales, Juan Cristobal, Malan, Daniel R., Šalek, Silva Zupančić, Wang, Michael, Boggio, Lisa N., Hegemann, Inga, Mital, Andrzej, Cardinal, Matthew, Zhu, Tong, Sun, Pengling, Arkin, Steven

“…Summary A phase 1b/2, three‐month study of marstacimab, a human monoclonal antibody targeting tissue factor pathway inhibitor (TFPI), was conducted in…”
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Benzene and its metabolite decreases cell proliferation via LncRNA-OBFC2A-mediated anti-proliferation effect involving NOTCH1 and KLF15 by Sun, Pengling, Wang, Jing, Guo, Xiaoli, Chen, Yujiao, Xing, Caihong, Gao, Ai

“…LncRNA has been considered to play a crucial role in the progression of several diseases by affecting cell proliferation. However, its role in benzene toxicity…”
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Gene Therapy with Fidanacogene Elaparvovec in Adults with Hemophilia B by Cuker, Adam, Kavakli, Kaan, Frenzel, Laurent, Wang, Jiaan-Der, Astermark, Jan, Cerqueira, Monica H., Iorio, Alfonso, Katsarou-Fasouli, Olga, Klamroth, Robert, Shapiro, Amy D., Hermans, Cédric, Ishiguro, Akira, Leavitt, Andrew D., Oldenburg, Johannes B., Ozelo, Margareth C., Teitel, Jerome, Biondo, Francesca, Fang, Annie, Fuiman, Joanne, McKay, John, Sun, Pengling, Rasko, John E.J., Rupon, Jeremy

“…In participants with hemophilia B, fidanacogene elaparvovec was superior to factor IX prophylaxis, with a lower bleeding rate and stable factor IX expression…”
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MiR-133a regarded as a potential biomarker for benzene toxicity through targeting Caspase-9 to inhibit apoptosis induced by benzene metabolite (1,4-Benzoquinone) by Chen, Yujiao, Sun, Pengling, Bai, Wenlin, Gao, Ai

“…Benzene is an environmental and industrial chemical which is widely utilized in various applications. Our previous study showed that miR-133a expression was…”
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Downregulation of B-cell lymphoma/leukemia-2 by overexpressed microRNA 34a enhanced titanium dioxide nanoparticle-induced autophagy in BEAS-2B cells by Bai, Wenlin, Chen, Yujiao, Sun, Pengling, Gao, Ai

“…Titanium dioxide (TiO2) nanoparticles (TNPs) are manufactured worldwide for a wide range of applications and the toxic effect of TNPs on biological systems is…”
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Extending the Mannose 6-Phosphate Glycoproteome by High Resolution/Accuracy Mass Spectrometry Analysis of Control and Acid Phosphatase 5-Deficient Mice by Sleat, David E., Sun, Pengling, Wiseman, Jennifer A., Huang, Ling, El-Banna, Mukarram, Zheng, Haiyan, Moore, Dirk F., Lobel, Peter

“…In mammals, most newly synthesized lumenal lysosomal proteins are delivered to the lysosome by the mannose 6-phosphate (Man6P) targeting pathway. Man6P…”
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STAT3 methylation in white blood cells as a novel sensitive biomarker for the toxic effect of low-dose benzene exposure by Liu, Di, Chen, Yujiao, Sun, Pengling, Bai, Wenlin, Gao, Ai

“…Alterations in DNA methylation patterns play an essential role in disease process and are associated with cancer risk. To explore the toxic effect and early…”
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Balancing Education and Service in Graduate Medical Education: Data From Pediatric Trainees and Program Directors by Kesselheim, Jennifer C, Sun, Pengling, Woolf, Alan D, London, Wendy B, Boyer, Debra

“…PURPOSETo measure pediatric program directors’ (PDs’) and trainees’ perceptions of and expectations for the balance of service and education in their training…”
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Activating Transcription Factor 4 Modulates BDNF Release from Microglial Cells by Sun, Pengling, Li, Xiangnan, Chen, Chengwen, Chen, Qianbo, Ouyang, Qing, Liu, Fangting, Xiang, Zhenghua, Yuan, Hongbin

“…Pathogenic pain is a common sign of many diseases. The mechanism is unclear. Activating transcription factor 4 (ATF4) plays a critical role in cell activation…”
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Predictors of neoplastic disease in children with isolated pituitary stalk thickening by Robison, Nathan J., Prabhu, Sanjay P., Sun, Pengling, Chi, Susan N., Kieran, Mark W., Manley, Peter E., Cohen, Laurie E., Goumnerova, Liliana, Smith, Edward R., Scott, R. Michael, London, Wendy B., Ullrich, Nicole J.

“…Background The significance of pituitary stalk thickening (PST) on magnetic resonance imaging (MRI) is often unclear. We evaluated presenting symptoms, MRI…”
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Sleep dysfunction in long term survivors of craniopharyngioma by Manley, Peter E., McKendrick, Kiera, McGillicudy, Megan, Chi, Susan N., Kieran, Mark W., Cohen, Laurie E., Kothare, Sanjeev, Michael Scott, R., Goumnerova, Liliana C., Sun, Pengling, London, Wendy, Marcus, Karen J., Pomeroy, Scott L., Ullrich, Nicole J.

“…Craniopharyngiomas are slow growing tumors of the sellar and parasellar region and may also involve the hypothalamus. Treatment involves maximal surgical…”
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Evaluation of the necessity of bilateral bone marrow aspirates and biopsies for the diagnosis of metastatic disease in pediatric patients with solid tumors by Abrantes, Fernanda L., Vergamini, Lucas B., Rodriguez-Galindo, Carlos, Hofmann, Inga, London, Wendy B., Ribeiro, Karina Braga, Frazier, A. Lindsay, Sun, Pengling

“…Abstract only 10054 Background: Standard practice for staging solid tumors has been to perform bilateral bone marrow aspirates (BMA) and biopsies (BMB)…”
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