Experimental application of Holmium:yttrium-aluminum-garnet laser-induced shock wave as a drug delivery system
One of the possible applications of shock waves is enhancement of drug delivery in the central nervous system. To achieve such a goal, it is necessary to develop a suitable shock wave source with the ability to be integrated with an endoscope or a catheter. We have developed a shock wave generator u...
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| Published in: | The Journal of the Acoustical Society of America Vol. 120; no. 5_Supplement; p. 3066 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
01-11-2006
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| Online Access: | Get full text |
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| Summary: | One of the possible applications of shock waves is enhancement of drug delivery in the central nervous system. To achieve such a goal, it is necessary to develop a suitable shock wave source with the ability to be integrated with an endoscope or a catheter. We have developed a shock wave generator using a pulsed Ho:YAG laser as the energy source; this device is remarkable for its ability to expose shock wave to target tissue in a localized area. The physical feature and characteristics of the generator were clarified. The overpressures of Ho:YAG laser-induced cavitational shock waves were measured by using a PVDF needle hydrophone. Maximum overpressure of 19 MPa at 4-mm distance from tip of the device was obtained. As a preliminary experiment, the device was applied to evaluate the enhancement of chemotherapeutic effects of shock wave in vitro, using human gastric cancer cell (GCIY cell) line and an anticancer drug (Bleomycin: BLM). Proliferation rate of the cells decreased to 90% and 45%, after application of 4000 and 6000 shots of shock waves at the BLM concentration of 1 mic-g/ml. Inhibitions in proliferation rate were observed in accordance with the number of shock wave applications and BLM concentrations. |
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| Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Conference-1 ObjectType-Feature-3 content type line 23 SourceType-Conference Papers & Proceedings-2 |
| ISSN: | 0001-4966 1520-8524 |
| DOI: | 10.1121/1.4787348 |