Search Results - "Sun, Melody S."
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Prenatal alcohol exposure alters mRNA expression for stress peptides, glucocorticoid receptor function and immune factors in acutely stressed neonatal brain
Published in Frontiers in neuroscience (23-06-2023)“…The amygdala, hippocampus and hypothalamus are critical stress regulatory areas that undergo functional maturation for stress responding initially established…”
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Prenatal alcohol exposure dysregulates spinal and circulating immune cell circular RNA expression in adult female rats with chronic sciatic neuropathy
Published in Frontiers in neuroscience (09-06-2023)“…Alcohol consumption during pregnancy is associated with Fetal Alcohol Spectrum Disorders (FASD) that results in a continuum of central nervous system (CNS)…”
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Prenatal alcohol exposure potentiates chronic neuropathic pain, spinal glial and immune cell activation and alters sciatic nerve and DRG cytokine levels
Published in Brain, behavior, and immunity (01-03-2017)“…Highlights • Moderate prenatal alcohol exposure (PAE) potentiates chronic neuropathic pain. • PAE induces exaggerated spinal glial activation following…”
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Maternal alcohol drinking patterns predict offspring neurobehavioral outcomes
Published in Neuropharmacology (01-10-2024)“…The timing, rate, and quantity of gestational alcohol consumption, collectively referred to here as Maternal Drinking Patterns (MDPs), are of known importance…”
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The maternal-placental-fetal interface: Adaptations of the HPA axis and immune mediators following maternal stress and prenatal alcohol exposure
Published in Experimental neurology (01-09-2022)“…This review addresses underlying physiological, cellular, and molecular factors that alter the developing fetal brain stress circuits and responses of the…”
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Effects of spinal non-viral interleukin-10 gene therapy formulated with d-mannose in neuropathic interleukin-10 deficient mice: Behavioral characterization, mRNA and protein analysis in pain relevant tissues
Published in Brain, behavior, and immunity (01-03-2018)“…•Intrathecal non-viral IL-10/d-mannose gene therapy acts without endogenous IL-10.•Intrathecal IL-10 transgene is expressed in the DRG but not the lumbar…”
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Effects of prenatal opioid and alcohol exposures on immune and serotonin factors in human placenta
Published in Experimental neurology (01-07-2022)“…Opioids and alcohol impact critical serotonin (5-HT) function in the developing placenta and fetus through the actions of immune proinflammatory factors. Yet,…”
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The LFA-1 antagonist BIRT377 reverses neuropathic pain in prenatal alcohol-exposed female rats via actions on peripheral and central neuroimmune function in discrete pain-relevant tissue regions
Published in Brain, behavior, and immunity (01-07-2020)“…•Prenatal alcohol exposure (PAE) creates a risk of neuropathic pain in female rats.•Enhanced T cell proinflammatory factors are observed in PAE nerve-injured…”
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Chronic Sciatic Neuropathy in Rat Reduces Voluntary Wheel-Running Activity With Concurrent Chronic Mechanical Allodynia
Published in Anesthesia and analgesia (01-01-2017)“…BACKGROUND:Animal models of peripheral neuropathy produced by a number of manipulations are assessed for the presence of pathologic pain states such as…”
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