Search Results - "Sun, Linchong"

cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions by Sun, Linchong, Song, Libing, Wan, Qianfen, Wu, Gongwei, Li, Xinghua, Wang, Yinghui, Wang, Jin, Liu, Zhaoji, Zhong, Xiuying, He, Xiaoping, Shen, Shengqi, Pan, Xin, Li, Ailing, Wang, Yulan, Gao, Ping, Tang, Huiru, Zhang, Huafeng

“…Cancer cells are known to undergo metabolic reprogramming to sustain survival and rapid proliferation, however, it remains to be fully elucidated how oncogenic…”
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Small molecules remain on target for c-Myc by Sun, Linchong, Gao, Ping

“…Targeting the transcription factor c-Myc via one of its coactivator proteins is a promising strategy for cancer therapy…”
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HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression by Huang, De, Li, Tingting, Li, Xinghua, Zhang, Long, Sun, Linchong, He, Xiaoping, Zhong, Xiuying, Jia, Dongya, Song, Libing, Semenza, Gregg L., Gao, Ping, Zhang, Huafeng

“…Hypoxia-inducible factor 1 (HIF-1) mediates a metabolic switch that blocks the conversion of pyruvate to acetyl-CoA in cancer cells. Here, we report that…”
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Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1 by Ma, Xiaoyu, Li, Chenchen, Sun, Linchong, Huang, De, Li, Tingting, He, Xiaoping, Wu, Gongwei, Yang, Zheng, Zhong, Xiuying, Song, Libing, Gao, Ping, Zhang, Huafeng

“…Aberrant expression of Lin28 and let-7 has been observed in many human malignancies. However, its functions and underlying mechanisms remain largely elusive…”
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Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis by Xiang, Yan, Stine, Zachary E, Xia, Jinsong, Lu, Yunqi, O'Connor, Roddy S, Altman, Brian J, Hsieh, Annie L, Gouw, Arvin M, Thomas, Ajit G, Gao, Ping, Sun, Linchong, Song, Libing, Yan, Benedict, Slusher, Barbara S, Zhuo, Jingli, Ooi, London L, Lee, Caroline G L, Mancuso, Anthony, McCallion, Andrew S, Le, Anne, Milone, Michael C, Rayport, Stephen, Felsher, Dean W, Dang, Chi V

“…Glutaminase (GLS), which converts glutamine to glutamate, plays a key role in cancer cell metabolism, growth, and proliferation. GLS is being explored as a…”
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Itaconate promotes hepatocellular carcinoma progression by epigenetic induction of CD8+ T-cell exhaustion by Gu, Xuemei, Wei, Haoran, Suo, Caixia, Shen, Shengqi, Zhu, Chuxu, Chen, Liang, Yan, Kai, Li, Zhikun, Bian, Zhenhua, Zhang, Pinggen, Yuan, Mengqiu, Yu, Yingxuan, Du, Jinzhi, Zhang, Huafeng, Sun, Linchong, Gao, Ping

“…Itaconate is a well-known immunomodulatory metabolite; however, its role in hepatocellular carcinoma (HCC) remains unclear. Here, we find that…”
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Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway by Ma, Xiaoyu, Wang, Lin, Huang, De, Li, Yunyan, Yang, Dongdong, Li, Tingting, Li, Fudong, Sun, Linchong, Wei, Haoran, He, Kun, Yu, Fazhi, Zhao, Debiao, Hu, Lan, Xing, Songge, Liu, Zhaoji, Li, Kui, Guo, Jing, Yang, Zhenye, Pan, Xin, Li, Ailing, Shi, Yunyu, Wang, Junfeng, Gao, Ping, Zhang, Huafeng

“…Two hallmarks for cancer cells are the accelerated cell cycle progression as well as the altered metabolism, however, how these changes are coordinated to…”
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Secreted protease PRSS35 suppresses hepatocellular carcinoma by disabling CXCL2-mediated neutrophil extracellular traps by Wang, Ting, Zhou, Yingli, Zhou, Zilong, Zhang, Pinggen, Yan, Ronghui, Sun, Linchong, Ma, Wenhao, Zhang, Tong, Shen, Shengqi, Liu, Haiying, Lu, Hui, Ye, Ling, Feng, Junru, Chen, Zhaolin, Zhong, Xiuying, Wu, Gao, Cai, Yongping, Jia, Weidong, Gao, Ping, Zhang, Huafeng

“…Hepatocytes function largely through the secretion of proteins that regulate cell proliferation, metabolism, and intercellular communications. During the…”
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Citrullination modulation stabilizes HIF-1α to promote tumour progression by Chen, Rui, Lin, Zhiyuan, Shen, Shengqi, Zhu, Chuxu, Yan, Kai, Suo, Caixia, Liu, Rui, Wei, Haoran, Gao, Li, Fan, Kaixiang, Zhang, Huafeng, Sun, Linchong, Gao, Ping

“…Citrullination plays an essential role in various physiological or pathological processes, however, whether citrullination is involved in regulating tumour…”
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Metformin sensitises hepatocarcinoma cells to methotrexate by targeting dihydrofolate reductase by Wang, Yinghui, Lu, Hui, Sun, Linchong, Chen, Xin, Wei, Haoran, Suo, Caixia, Feng, Junru, Yuan, Mengqiu, Shen, Shengqi, Jia, Weidong, Wang, Ying, Zhang, Huafeng, Li, Zijun, Zhong, Xiuying, Gao, Ping

“…Metformin, the first-line drug for type II diabetes, has recently been considered an anticancer agent. However, the molecular target and underlying mechanism…”
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Menin enhances c-Myc-mediated transcription to promote cancer progression by Wu, Gongwei, Yuan, Mengqiu, Shen, Shengqi, Ma, Xiaoyu, Fang, Jingwen, Zhu, Lianbang, Sun, Linchong, Liu, Zhaoji, He, Xiaoping, Huang, De, Li, Tingting, Li, Chenchen, Wu, Jun, Hu, Xin, Li, Zhaoyong, Song, Libing, Qu, Kun, Zhang, Huafeng, Gao, Ping

“…Menin is an enigmatic protein that displays unique ability to either suppress or promote tumorigenesis in a context-dependent manner. The role for Menin to…”
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Mitochondrion-Localized SND1 Promotes Mitophagy and Liver Cancer Progression Through PGAM5 by Liang, Shiwei, Zhu, Chuxu, Suo, Caixia, Wei, Haoran, Yu, Yingxuan, Gu, Xuemei, Chen, Liang, Yuan, Mengqiu, Shen, Shengqi, Li, Shiting, Sun, Linchong, Gao, Ping

“…Staphylococcal nuclease domain-containing protein 1 (SND1) is an evolutionarily conserved multifunctional protein that functions mainly in the nucleus and…”
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MicroRNAs and the Warburg Effect: new players in an old arena by Gao, Ping, Sun, Linchong, He, Xiaoping, Cao, Yang, Zhang, Huafeng

“…It is known that tumor cells adapt characteristic metabolic phenotypes during cancer initiation and progression. The hallmark of tumor metabolism is aerobic…”
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KDELR2 promotes breast cancer proliferation via HDAC3‐mediated cell cycle progression by Wei, Haoran, Ma, Wenhao, Lu, Xiaofei, Liu, Haiying, Lin, Kashuai, Wang, Yinghui, Ye, Zijian, Sun, Linchong, Huang, Zhitong, Pan, Tingting, Zhou, Zilong, Cheng, Eric Y., Zhang, Huafeng, Gao, Ping, Zhong, Xiuying

“…Background Histone deacetylases (HDACs) engage in the regulation of various cellular processes by controlling global gene expression. The dysregulation of…”
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Correction: Author Correction: Menin enhances c-Myc-mediated transcription to promote cancer progression by Wu, Gongwei, Yuan, Mengqiu, Shen, Shengqi, Ma, Xiaoyu, Fang, Jingwen, Zhu, Lianbang, Sun, Linchong, Liu, Zhaoji, He, Xiaoping, Huang, De, Li, Tingting, Li, Chenchen, Wu, Jun, Hu, Xin, Li, Zhaoyong, Song, Libing, Qu, Kun, Zhang, Huafeng, Gao, Ping

“…Nature Communications 8: Article number: 15278 (2017); Published 5 May 2017; Updated 30 March 2018 The originally published version of this Article contained…”
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Metabolic reprogramming and epigenetic modifications on the path to cancer by Sun, Linchong, Zhang, Huafeng, Gao, Ping

“…Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally regulate each other, are among the well-known cancer hallmarks. Recent…”
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2-Oxonanonoidal Antibiotic Actinolactomycin Inhibits Cancer Progression by Suppressing HIF-1α by Cheng, Jiadong, Hu, Lan, Yang, Zheng, Suo, Caixia, Wang, Yueyang Jack, Gao, Ping, Cui, Chengbin, Sun, Linchong

“…HIF-1 serves as an important regulator in cell response to hypoxia. Due to its key role in promoting tumor survival and progression under hypoxia, HIF-1 has…”
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An idle PHGDH takes control of cell fate by Sun, Linchong, Gao, Ping

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Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect by Sun, Linchong, Suo, Caixia, Li, Shi-ting, Zhang, Huafeng, Gao, Ping

“…While metabolic reprogramming of cancer cells has long been considered from the standpoint of how and why cancer cells preferentially utilize glucose via…”
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Noncoding RNAs in Regulation of Cancer Metabolic Reprogramming by Yang, Dongdong, Sun, Linchong, Li, Zhaoyong, Gao, Ping

“…Since the description of the Warburg effect 90 years ago, metabolic reprogramming has been gradually recognized as a major hallmark of cancer cells. Mounting…”
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