Search Results - "Sun, Jixue"

Programming DNA origami patterning with non-canonical DNA-based metallization reactions by Jia, Sisi, Wang, Jianbang, Xie, Mo, Sun, Jixue, Liu, Huajie, Zhang, Yinan, Chao, Jie, Li, Jiang, Wang, Lihua, Lin, Jianping, Gothelf, Kurt V., Fan, Chunhai

“…The inherent specificity of DNA sequence hybridization has been extensively exploited to develop bioengineering applications. Nevertheless, the structural…”
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Mechanism of the Conformational Change of the Protein Methyltransferase SMYD3: A Molecular Dynamics Simulation Study by Sun, Jixue, Li, Zibin, Yang, Na

“…SMYD3 is a SET-domain-containing methyltransferase that catalyzes the transfer of methyl groups onto lysine residues of substrate proteins. Methylation of…”
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Mechanism studies of the activation of DNA methyltransferase DNMT1 triggered by histone H3 ubiquitination, revealed by multi-scale molecular dynamics simulations by Sun, Jixue, Liu, Fei, Yuan, Longxiao, Pang, Ning-Ning, Zhu, Bing, Yang, Na

“…DNMT1 is a DNA methyltransferase that catalyzes and maintains methylation in CpG dinucleotides. It blocks the entrance of DNA into the catalytic pocket via the…”
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Study of the mechanism of protonated histidine-induced conformational changes in the Zika virus dimeric envelope protein using accelerated molecular dynamic simulations by Sun, Jixue, Li, Yang, Liu, Pi, Lin, Jianping

“…[Display omitted] •The bilayer could lead to a curvature induced by the transmembrane region of the Zika virus envelope protein.•The low pH condition could…”
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Engineering catechol 1, 2-dioxygenase by design for improving the performance of the cis, cis-muconic acid synthetic pathway in Escherichia coli by Han, Li, Liu, Pi, Sun, Jixue, Wu, Yuanqing, Zhang, Yuanyuan, Chen, Wujiu, Lin, Jianping, Wang, Qinhong, Ma, Yanhe

“…Regulating and ameliorating enzyme expression and activity greatly affects the performance of a given synthetic pathway. In this study, a new synthetic pathway…”
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Exploration of the Substrate Preference of Lysine Methyltransferase SMYD3 by Molecular Dynamics Simulations by Sun, Jixue, Shi, Fandi, Yang, Na

“…SMYD3, a SET and MYND domain containing lysine methyltransferase, catalyzes the transfer of the methyl group from a methyl donor onto the Nε group of a lysine…”
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An integrated strategy of ultra-high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry and virtual screening for the identification of α-glucosidase inhibitors in acarviostatin-containing complex by Wang, Liqiang, Cui, Qingxin, Hou, Yuanyuan, Bai, Fang, Sun, Jixue, Cao, Xiaofang, Liu, Pi, Jiang, Min, Bai, Gang

“…•UPLC/Q-TOF-MS and virtual docking were integrated to identify inhibitors of multiple human α-glucosidases.•The system solved the issue of trace quantities…”
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Charge Neutralization Drives the Shape Reconfiguration of DNA Nanotubes by Liu, Pi, Zhao, Yan, Liu, Xiaoguo, Sun, Jixue, Xu, Dede, Li, Yang, Li, Qian, Wang, Lihua, Yang, Sichun, Fan, Chunhai, Lin, Jianping

“…Reconfiguration of membrane protein channels for gated transport is highly regulated under physiological conditions. However, a mechanistic understanding of…”
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The full activation mechanism of the adenosine A1 receptor revealed by GaMD and Su-GaMD simulations by Li, Yang, Sun, Jixue, Li, Dongmei, Lin, Jianping

“…The full activation process of G protein–coupled receptor (GPCR) plays an important role in cellular signal transduction. However, it remains challenging to…”
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Structural characterization of fungus-specific histone deacetylase Hos3 provides insights into developing selective inhibitors with antifungal activity by Pang, Ningning, Sun, Jixue, Che, Shiyou, Yang, Na

“…Fungal infection has long been a chronic and even life-threatening problem for humans. The demand for new antifungal drugs has increased dramatically as fungal…”
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The full activation mechanism of the adenosine A 1 receptor revealed by GaMD and Su-GaMD simulations by Li, Yang, Sun, Jixue, Li, Dongmei, Lin, Jianping

“…The full activation process of G protein-coupled receptor (GPCR) plays an important role in cellular signal transduction. However, it remains challenging to…”
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Insight into the origin of SARS-CoV-2 through structural analysis of receptor recognition: a molecular simulation study by Sun, Jixue, Liu, Meijiang, Yang, Na

“…Bats and pangolins are considered to be potential hosts of the new coronavirus SARS-CoV-2, based on its genome similarity to coronaviruses of these species…”
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Comprehensive Insights into the Catalytic Mechanism of Middle East Respiratory Syndrome 3C-Like Protease and Severe Acute Respiratory Syndrome 3C-Like Protease by Wang, Hao, He, Shuai, Deng, Weilong, Zhang, Ying, Li, Guobang, Sun, Jixue, Zhao, Wei, Guo, Yu, Yin, Zheng, Li, Dongmei, Shang, Luqing

“…Coronavirus 3C-like protease (3CLPro) is a highly conserved cysteine protease employing a catalytic dyad for its functions. 3CLPro is essential to the viral…”
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Structure specific DNA recognition by the SLX1–SLX4 endonuclease complex by Xu, Xiang, Wang, Mingzhu, Sun, Jixue, Yu, Zhenyu, Li, Guohong, Yang, Na, Xu, Rui-Ming

“…Abstract The SLX1–SLX4 structure-specific endonuclease complex is involved in processing diverse DNA damage intermediates, including resolution of Holliday…”
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Substrate binding and inhibition mechanism of norepinephrine transporter by Ji, Wenming, Miao, Anran, Liang, Kai, Liu, Jiameng, Qi, Yuhan, Zhou, Yue, Duan, Xinli, Sun, Jixue, Lai, Lipeng, Wu, Jing-Xiang

“…Norepinephrine transporter (NET; encoded by SLC6A2 ) reuptakes the majority of the released noradrenaline back to the presynaptic terminals, thereby affecting…”
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Activation and conformational dynamics of a class B G-protein-coupled glucagon receptor by Li, Yang, Sun, Jixue, Li, Dongmei, Lin, Jianping

“…The human glucagon receptor (GCGR) is a class B G-protein-coupled receptor (GPCR). The GCGR can be activated by glucagon and regulates the release of glucose…”
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Molecular architecture of the acetohydroxyacid synthase holoenzyme by Zhang, Yingying, Li, Yang, Liu, Xiao, Sun, Jixue, Li, Xin, Lin, Jianping, Yang, Xue, Xi, Zhen, Shen, Yuequan

“…The acetohydroxyacid synthase (AHAS) holoenzyme catalyzes the first step of branch-chain amino acid biosynthesis and is essential for plants and bacteria. It…”
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Studying the adsorption of DNA nanostructures on graphene in the aqueous phase using molecular dynamic simulations by Sun, Jixue, Li, Yang, Lin, Jianping

“…[Display omitted] •The single-stranded DNA could be easily adsorbed on the graphene.•DNA polymer could be adsorbed on the graphene by the flexible…”
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Crystal Structure of African Swine Fever Virus pS273R Protease and Implications for Inhibitor Design by Li, Guobang, Liu, Xiaoxia, Yang, Mengyuan, Zhang, Guangshun, Wang, Zhengyang, Guo, Kun, Gao, Yuxue, Jiao, Peng, Sun, Jixue, Chen, Cheng, Wang, Hao, Deng, Weilong, Xiao, Huihe, Li, Sizheng, Wu, Haoru, Wang, Ying, Cao, Lin, Jia, Zihan, Shang, Luqing, Yang, Cheng, Guo, Yu, Rao, Zihe

“…African swine fever (ASF) is a highly contagious hemorrhagic viral disease of domestic and wild pigs that is responsible for serious economic and production…”
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Charge Neutralization Drives the Shape Reconfiguration of DNA Nanotubes by Liu, Pi, Zhao, Yan, Liu, Xiaoguo, Sun, Jixue, Xu, Dede, Li, Yang, Li, Qian, Wang, Lihua, Yang, Sichun, Fan, Chunhai, Lin, Jianping

“…Reconfiguration of membrane protein channels for gated transport is highly regulated under physiological conditions. However, a mechanistic understanding of…”
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