Search Results - "Sun, Jinyao"
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Apigenin-Mn(II) loaded hyaluronic acid nanoparticles for ulcerative colitis therapy in mice
Published in Frontiers in chemistry (22-07-2022)“…Ulcerative colitis (UC) is a chronic idiopathic inflammatory bowel disease characterized by rapid progression and frequent comorbidities that make its…”
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Pharmacokinetic/pharmacodynamic evaluation of linezolid for the treatment of staphylococcal infections in critically ill patients
Published in International journal of antimicrobial agents (01-09-2016)“…Highlights • Factors influencing the efficacy of linezolid treatment were analysed. • The target for successful treatment in critically staphylococcal…”
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Inhibitory effect of ultrasonic stimulation on the voltage-dependent potassium currents in rat hippocampal CA1 neurons
Published in BMC neuroscience (05-01-2019)“…Transcranial ultrasonic stimulation is a novel noninvasive tool for neuromodulation, and has high spatial resolution and deep penetration. Although it can…”
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Antibiotic consumption versus the prevalence of carbapenem-resistant Gram-negative bacteria at a tertiary hospital in China from 2011 to 2017
Published in Journal of infection and public health (01-03-2019)“…China launched a 3-year rectification scheme on the clinical use of antibiotics in 2011, and a specific scheme on carbapenem use in February 2017. This study…”
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Clinical pharmacokinetic/pharmacodynamic profile of linezolid in severely ill Intensive Care Unit patients
Published in International journal of antimicrobial agents (01-10-2011)“…Abstract Severely ill Intensive Care Unit (ICU) patients have an increased risk of developing multiresistant Gram-positive infections, largely due to the…”
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Efficacy and safety of voriconazole and CYP2C19 polymorphism for optimised dosage regimens in patients with invasive fungal infections
Published in International journal of antimicrobial agents (01-11-2014)“…Highlights • Voriconazole Cmin of 1.5–4 mg/L will with appropriate clinical efficacy and safety. • CYP2C19 genetic status or Cmin / CN values will be help to…”
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Metabolic characteristics of voriconazole – Induced liver injury in rats
Published in Chemico-biological interactions (25-09-2023)“…Voriconazole (VOR) – induced liver injury is a common adverse reaction, and can lead to serious clinical outcomes. It is of great significance to describe the…”
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Anti-Inflammatory and Anti-Oxidant Impacts of Lentinan Combined with Probiotics in Ulcerative Colitis
Published in Molecular biotechnology (01-10-2024)“…Multi-methods have been developed to control ulcerative colitis. This research targeted to probe that lentinan combined with probiotics suppresses inflammation…”
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Population Pharmacokinetics of Tigecycline in Critically Ill Patients with Severe Infections
Published in Antimicrobial agents and chemotherapy (01-08-2017)“…We sought to describe the population pharmacokinetics of tigecycline in critically ill patients and to determine optimized dosing regimens of tigecycline for…”
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Colon-targeting mutual prodrugs of 5-aminosalicylic acid and butyrate for the treatment of ulcerative colitis
Published in RSC advances (01-01-2018)“…The aim of this study was to design and synthesize four colon-targeting mutual prodrugs of 5-aminosalicylic acid (5-ASA) and butyrate, and evaluate their…”
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Enhanced transdermal delivery of sinomenine hydrochloride by ethosomes for anti-inflammatory treatment
Published in Journal of drug delivery science and technology (01-12-2016)“…Sinomenine hydrochloride (SH) is a valuable anti-inflammatory drug. However, the application of SH is limited by its short half-life and side effects. The aim…”
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Ameliorative effects of 3,4-oxo-isopropylidene-shikimic acid on experimental colitis and their mechanisms in rats
Published in International immunopharmacology (01-03-2013)“…The aim of the present study was to investigate the therapeutic effect and mechanism of 3,4-oxo-isopropylidene-shikimic acid (ISA) on…”
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Optimal tigecycline dosage regimen is urgently needed: results from a pharmacokinetic/pharmacodynamic analysis of tigecycline by Monte Carlo simulation
Published in International journal of infectious diseases (01-01-2014)“…Summary Background The number of reported cases of resistance to tigecycline is increasing. The aim of this study was to evaluate the current standard…”
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Improvement of side-effects and treatment on the experimental colitis in mice of a resin microcapsule-loading hydrocortisone sodium succinate
Published in Drug development and industrial pharmacy (04-03-2017)“…Context: Extensive or long-time use of corticosteroids often causes many toxic side-effects. The ion exchange resins and the coating material, Eudragit, can be…”
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Proteomic analysis of the proteins that are associated with the resistance to paclitaxel in human breast cancer cells
Published in Molecular bioSystems (01-02-2014)“…Cancers frequently develop resistance to paclitaxel but the underlying molecular mechanisms remain to be determined. We have investigated the proteins that are…”
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Anti-Inflammatory Effect of 3,4-Oxo-isopropylidene-shikimic Acid on Acetic Acid-Induced Colitis in Rats
Published in Inflammation (01-12-2012)“…The present work was done to investigate the possible effects of 3,4-oxo-isopropylidene-shikimic acid (ISA) on acetic acid (AA)-induced colitis in rats…”
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Investigation of the colon-targeting, improvement on the side-effects and therapy on the experimental colitis in mouse of a resin microcapsule loading dexamethasone sodium phosphate
Published in Drug delivery (23-07-2016)“…Dexamethasone is the major drug in the treatment of ulcerative colitis (UC). However, the extensive or long-time use of dexamethasone causes many toxic…”
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