Search Results - "Sun, Jim"

An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis by Näär, Anders M, Yang, Fajun, Vought, Bryan W, Satterlee, John S, Walker, Amy K, Jim Sun, Z.-Y, Watts, Jennifer L, DeBeaumont, Rosalie, Mako Saito, R, Hyberts, Sven G, Yang, Shaosong, Macol, Christine, Iyer, Lakshmanan, Tjian, Robert, van den Heuvel, Sander, Hart, Anne C, Wagner, Gerhard

“…The sterol regulatory element binding protein (SREBP) family of transcription activators are critical regulators of cholesterol and fatty acid homeostasis. We…”
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Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H+—ATPase to inhibit phagosome acidification by Wong, Dennis, Bach, Horacio, Sun, Jim, Hmama, Zakaria, Av-Gay, Yossef

“…Mycobacterium tuberculosis (Mtb) pathogenicity depends on its ability to inhibit phagosome acidification and maturation processes after engulfment by…”
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NAD+ Depletion Triggers Macrophage Necroptosis, a Cell Death Pathway Exploited by Mycobacterium tuberculosis by Pajuelo, David, Gonzalez-Juarbe, Norberto, Tak, Uday, Sun, Jim, Orihuela, Carlos J., Niederweis, Michael

“…Mycobacterium tuberculosis (Mtb) kills infected macrophages by inhibiting apoptosis and promoting necrosis. The tuberculosis necrotizing toxin (TNT) is a…”
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Protein Kinase R in Bacterial Infections: Friend or Foe? by Smyth, Robin, Sun, Jim

“…The global antimicrobial resistance crisis poses a significant threat to humankind in the coming decades. Challenges associated with the development of novel…”
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Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy by Jiang, Liwei, Wang, Yi-Jun, Zhao, Jing, Uehara, Mayuko, Hou, Qingming, Kasinath, Vivek, Ichimura, Takaharu, Banouni, Naima, Dai, Li, Li, Xiaofei, Greiner, Dale L., Shultz, Leonard D., Zhang, Xiaolong, Sun, Zhen-Yu Jim, Curtin, Ian, Vangos, Nicholas E., Yeoh, Zoe C., Geffken, Ezekiel A., Seo, Hyuk-Soo, Liu, Ze-Xian, Heffron, Gregory J., Shah, Khalid, Dhe-Paganon, Sirano, Abdi, Reza

“…Cancer therapies kill tumors either directly or indirectly by evoking immune responses and have been combined with varying levels of success. Here, we describe…”
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The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD by Sun, Jim, Siroy, Axel, Lokareddy, Ravi K, Speer, Alexander, Doornbos, Kathryn S, Cingolani, Gino, Niederweis, Michael

“…The Mycobacterium tuberculosis necrotizing toxin (TNT) is shown to cause toxicity by hydrolyzing NAD + in the host cell. The crystal structure of TNT bound to…”
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Mycobacterium tuberculosis Exploits Focal Adhesion Kinase to Induce Necrotic Cell Death and Inhibit Reactive Oxygen Species Production by Afriyie-Asante, Afrakoma, Dabla, Ankita, Dagenais, Amy, Berton, Stefania, Smyth, Robin, Sun, Jim

“…Tuberculosis is a deadly, contagious respiratory disease that is caused by the pathogenic bacterium (Mtb). Mtb is adept at manipulating and evading host…”
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Protein Kinase R Restricts the Intracellular Survival of Mycobacterium tuberculosis by Promoting Selective Autophagy by Smyth, Robin, Berton, Stefania, Rajabalee, Nusrah, Chan, Therese, Sun, Jim

“…Tuberculosis (TB) is a deadly infectious lung disease caused by the pathogenic bacterium (Mtb). The identification of macrophage signaling proteins exploited…”
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TREM2 Promotes Immune Evasion by Mycobacterium tuberculosis in Human Macrophages by Dabla, Ankita, Liang, Yi Chu, Rajabalee, Nusrah, Irwin, Courtney, Moonen, Carolyn G. J., Willis, Jessie V., Berton, Stefania, Sun, Jim

“…Macrophage surface receptors are critical for pathogen defense, as they are the gatekeepers for pathogen entry and sensing, which trigger robust immune…”
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Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophages by Speer, Alexander, Sun, Jim, Danilchanka, Olga, Meikle, Virginia, Rowland, Jennifer L., Walter, Kerstin, Buck, Bradford R., Pavlenok, Mikhail, Hölscher, Christoph, Ehrt, Sabine, Niederweis, Michael

“…Summary Sphingomyelinases secreted by pathogenic bacteria play important roles in host–pathogen interactions ranging from interfering with phagocytosis and…”
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An outer membrane channel protein of Mycobacterium tuberculosis with exotoxin activity by Danilchanka, Olga, Sun, Jim, Pavlenok, Mikhail, Maueröder, Christian, Speer, Alexander, Siroy, Axel, Marrero, Joeli, Trujillo, Carolina, Mayhew, David L., Doornbos, Kathryn S., Muñoz, Luis E., Herrmann, Martin, Ehrt, Sabine, Berens, Christian, Niederweis, Michael

“…The ability to control the timing and mode of host cell death plays a pivotal role in microbial infections. Many bacteria use toxins to kill host cells and…”
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The phosphatase PPM1A controls monocyte-to-macrophage differentiation by Smith, Samuel R., Schaaf, Kaitlyn, Rajabalee, Nusrah, Wagner, Frederic, Duverger, Alexandra, Kutsch, Olaf, Sun, Jim

“…Differentiation of circulating monocytes into tissue-bound or tissue-resident macrophages is a critical regulatory process affecting host defense and…”
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Mycobacterium tuberculosis nucleoside diphosphate kinase inactivates small GTPases leading to evasion of innate immunity by Sun, Jim, Singh, Vijender, Lau, Alice, Stokes, Richard W, Obregón-Henao, Andrés, Orme, Ian M, Wong, Dennis, Av-Gay, Yossef, Hmama, Zakaria

“…Defining the mechanisms of Mycobacterium tuberculosis (Mtb) persistence in the host macrophage and identifying mycobacterial factors responsible for it are…”
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Frequency-Scanning Phased-Array Feed Network Based on Composite Right/Left-Handed Transmission Lines by Choi, Jun H., Sun, Jim S., Itoh, Tatsuo

“…This paper presents an all-passive phased-array feed network based on composite right/left handed (CRLH) transmission lines (TLs). A CRLH TL enables systematic…”
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Mycobacterial nucleoside diphosphate kinase blocks phagosome maturation in murine RAW 264.7 macrophages by Sun, Jim, Wang, Xuetao, Lau, Alice, Liao, Ting-Yu Angela, Bucci, Cecilia, Hmama, Zakaria

“…Microorganisms capable of surviving within macrophages are rare, but represent very successful pathogens. One of them is Mycobacterium tuberculosis (Mtb) whose…”
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Mycobacterium tuberculosis exploits the PPM1A signaling pathway to block host macrophage apoptosis by Schaaf, Kaitlyn, Smith, Samuel R., Duverger, Alexandra, Wagner, Frederic, Wolschendorf, Frank, Westfall, Andrew O., Kutsch, Olaf, Sun, Jim

“…The ability to suppress host macrophage apoptosis is essential for M. tuberculosis ( Mtb ) to replicate intracellularly while protecting it from antibiotic…”
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An in vivo biosafety-level-2-compatible model of Mycobacterium tuberculosis infection for drug susceptibility testing by Liang, Yi Chu, Berton, Stefania, Reeks, Courtney, Sun, Jim

“…Available mouse models for tuberculosis drug susceptibility testing requires using virulent biosafety-level-3 (BSL-3) Mycobacterium tuberculosis (Mtb) strains,…”
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Cytomegalovirus promotes intestinal macrophage-mediated mucosal inflammation through induction of Smad7 by Dennis, Evida A., Smythies, Lesley E., Grabski, Robert, Li, Mao, Ballestas, Mary E., Shimamura, Masako, Sun, Jim J., Grams, Jayleen, Stahl, Richard, Niederweis, Michael E., Britt, William J., Smith, Phillip D.

“…Intestinal macrophages in healthy human mucosa are profoundly down-regulated for inflammatory responses (inflammation anergy) due to stromal TGF-β inactivation…”
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Ring-Resonator-Inspired Power Recycling Scheme for Gain-Enhanced Distributed Amplifier-Based CRLH-Transmission Line Leaky Wave Antennas by Wu, C-T M., Yuandan Dong, Sun, J. S., Itoh, T.

“…We propose a novel power recycling scheme for distributed amplifiers (DAs) integrated with composite-right/left handed transmission line leaky wave antennas…”
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Discovery of benzo[c]phenanthridine derivatives with potent activity against multidrug-resistant Mycobacterium tuberculosis by Liang, Yi Chu, Sun, Zhiqi, Lu, Chen, Lupien, Andréanne, Xu, Zhongliang, Berton, Stefania, Xu, Peng, Behr, Marcel A, Yang, Weibo, Sun, Jim

“…(Mtb), the pathogen responsible for tuberculosis (TB), is the leading cause of bacterial disease-related death worldwide. Current antibiotic regimens for the…”
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