Search Results - "Sun, Jenny J"
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Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals
Published in eLife (29-11-2022)“…Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1 has been proposed as a potential therapeutic strategy for hearing…”
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Generation of Two Noradrenergic-Specific Dopamine-Beta-Hydroxylase-FLPo Knock-In Mice Using CRISPR/Cas9-Mediated Targeting in Embryonic Stem Cells
Published in PloS one (21-07-2016)“…CRISPR/Cas9 mediated DNA double strand cutting is emerging as a powerful approach to increase rates of homologous recombination of large targeting vectors, but…”
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Off-Target Effects of Clozapine-N-Oxide on the Chemosensory Reflex Are Masked by High Stress Levels
Published in Frontiers in physiology (22-05-2019)“…Respiratory chemosensory circuits are implicated in several physiological and behavioral disorders ranging from sudden infant death syndrome to panic disorder…”
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A CRISPR toolbox for generating intersectional genetic mouse models for functional, molecular, and anatomical circuit mapping
Published in BMC biology (28-01-2022)“…The functional understanding of genetic interaction networks and cellular mechanisms governing health and disease requires the dissection, and multifaceted…”
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Embryonic hindbrain patterning genes delineate distinct cardio-respiratory and metabolic homeostatic populations in the adult
Published in Scientific reports (22-08-2017)“…Previous studies based on mouse genetic mutations suggest that proper partitioning of the hindbrain into transient, genetically-defined segments called…”
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Tg(Th-Cre)FI172Gsat ( Th-Cre ) defines neurons that are required for full hypercapnic and hypoxic reflexes
Published in Biology open (15-08-2017)“…The catecholaminergic (CA) system has been implicated in many facets of breathing control and offers an important target to better comprehend the underlying…”
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It’s not the heart: autonomic nervous system predisposition to lethal ventricular arrhythmias
Published in Heart rhythm (01-11-2015)Get full text
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Lethal lung hypoplasia and vascular defects in mice with conditional Foxf1 overexpression
Published in Biology open (15-11-2016)“…FOXF1 heterozygous point mutations and genomic deletions have been reported in newborns with the neonatally lethal lung developmental disorder, alveolar…”
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Respiratory Network Stability and Modulatory Response to Substance P Require Nalcn
Published in Neuron (Cambridge, Mass.) (19-04-2017)“…Respiration is a rhythmic activity as well as one that requires responsiveness to internal and external circumstances; both the rhythm and neuromodulatory…”
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A low cost, simplified, and scaleable pneumotachograph and face mask for neonatal mouse respiratory measurements
Published in Journal of pharmacological and toxicological methods (01-07-2017)“…Neonatal respiratory disorders are a leading cause of perinatal mortality due to complications resulting from premature births and prenatal exposure to drugs…”
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