Search Results - "Sun, Hui B"

Mechanical loading, cartilage degradation, and arthritis by Sun, Hui B.

“…Joint tissues are exquisitely sensitive to their mechanical environment, and mechanical loading may be the most important external factor regulating the…”
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Mesenchymal stem cells in tendon repair and regeneration: basic understanding and translational challenges by Leong, Daniel J., Sun, Hui B.

“…Tendon injuries are common and present a clinical challenge because they often respond poorly to treatment and require prolonged rehabilitation. Current…”
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Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model by Zhang, Zhuo, Leong, Daniel J, Xu, Lin, He, Zhiyong, Wang, Angela, Navati, Mahantesh, Kim, Sun J, Hirsh, David M, Hardin, John A, Cobelli, Neil J, Friedman, Joel M, Sun, Hui B

“…Curcumin has been shown to have chondroprotective potential in vitro. However, its effect on disease and symptom modification in osteoarthritis (OA) is largely…”
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Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations by Kennedy, Oran D, Herman, Brad C, Laudier, Damien M, Majeska, Robert J, Sun, Hui B, Schaffler, Mitchell B

“…Abstract Osteocyte apoptosis is required to initiate osteoclastic bone resorption following fatigue-induced microdamage in vivo; however, it is unclear whether…”
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Osteocyte apoptosis is required for production of osteoclastogenic signals following bone fatigue in vivo by Kennedy, Oran D, Laudier, Damien M, Majeska, Robert J, Sun, Hui B, Schaffler, Mitchell B

“…Abstract Osteocyte apoptosis is spatially, temporally and functionally linked to the removal and replacement of microdamage in the bone. Recently we showed…”
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BMP-12 treatment of adult mesenchymal stem cells in vitro augments tendon-like tissue formation and defect repair in vivo by Lee, Jonathan Y, Zhou, Zuping, Taub, Peter J, Ramcharan, Melissa, Li, Yonghui, Akinbiyi, Takintope, Maharam, Edward R, Leong, Daniel J, Laudier, Damien M, Ruike, Takuya, Torina, Phillip J, Zaidi, Mone, Majeska, Robert J, Schaffler, Mitchell B, Flatow, Evan L, Sun, Hui B

“…We characterized the differentiation of rat bone marrow-derived mesenchymal stem cells (BM-MSCs) into tenocyte-like cells in response to bone morphogenetic…”
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The Role of Scleraxis in Fate Determination of Mesenchymal Stem Cells for Tenocyte Differentiation by Li, Yonghui, Ramcharan, Melissa, Zhou, Zuping, Leong, Daniel J., Akinbiyi, Takintope, Majeska, Robert J., Sun, Hui B.

“…Mesenchymal stem cells (MSCs) are pluripotent cells that primarily differentiate into osteocytes, chondrocytes and adipocytes. Recent studies indicate that…”
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Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model by Leong, Daniel J, Choudhury, Marwa, Hanstein, Regina, Hirsh, David M, Kim, Sun Jin, Majeska, Robert J, Schaffler, Mitchell B, Hardin, John A, Spray, David C, Goldring, Mary B, Cobelli, Neil J, Sun, Hui B

“…Abstract Introduction Epigallocatechin 3-gallate (EGCG), a polyphenol present in green tea, was shown to exert chondroprotective effects in vitro . In this…”
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Tendon‐derived stem/progenitor cell aging: defective self‐renewal and altered fate by Zhou, Zuping, Akinbiyi, Takintope, Xu, Lili, Ramcharan, Melissa, Leong, Daniel J., Ros, Stephen J., Colvin, Alexis C., Schaffler, Mitchell B., Majeska, Robert J., Flatow, Evan L., Sun, Hui B.

“…Summary Aging is a major risk factor for tendon injury and impaired tendon healing, but the basis for these relationships remains poorly understood. Here we…”
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Rho/Rock signal transduction pathway is required for MSC tenogenic differentiation by Maharam, Edward, Yaport, Miguel, Villanueva, Nathaniel L, Akinyibi, Takintope, Laudier, Damien, He, Zhiyong, Leong, Daniel J, Sun, Hui B

“…Mesenchymal stem cell （MSC）-based treatments have shown promise for improving tendon healing and repair. MSCs have the potential to differentiate into multiple…”
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Nutraceuticals: potential for chondroprotection and molecular targeting of osteoarthritis by Leong, Daniel J, Choudhury, Marwa, Hirsh, David M, Hardin, John A, Cobelli, Neil J, Sun, Hui B

“…Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult disability. There is no cure for OA, and no effective treatments which arrest…”
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CITED2 mechanoregulation of matrix metalloproteinases by Sun, Hui B.

“…Joint tissues are exquisitely sensitive to their mechanical environment. Indeed, mechanical loading may be the most important external factor regulating the…”
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Mechanical Loading: Bone Remodeling and Cartilage Maintenance by Yokota, Hiroki, Leong, Daniel J., Sun, Hui B.

“…Bone remodeling and cartilage maintenance are strongly influenced by biomechanical signals generated by mechanical loading. Although moderate loading is…”
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Advances of stem cell based-therapeutic approaches for tendon repair by Liu, Lidi, Hindieh, Jennifer, Leong, Daniel J., Sun, Hui B.

“…Tendon injuries are significant clinical problems. Current treatments often result in incomplete repair or healing, which may lead to reduced function and…”
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Physiological loading of joints prevents cartilage degradation through CITED2 by Leong, Daniel J, Li, Yong H, Gu, Xiang I, Sun, Li, Zhou, Zuping, Nasser, Philip, Laudier, Damien M, Iqbal, Jameel, Majeska, Robert J, Schaffler, Mitchell B, Goldring, Mary B, Cardoso, Luis, Zaidi, Mone, Sun, Hui B

“…Both overuse and disuse of joints up-regulate matrix metalloproteinases (MMPs) in articular cartilage and cause tissue degradation; however, moderate…”
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Procyanidins Mitigate Osteoarthritis Pathogenesis by, at Least in Part, Suppressing Vascular Endothelial Growth Factor Signaling by Wang, Angela, Leong, Daniel J, He, Zhiyong, Xu, Lin, Liu, Lidi, Kim, Sun Jin, Hirsh, David M, Hardin, John A, Cobelli, Neil J, Sun, Hui B

“…Procyanidins are a family of plant metabolites that have been suggested to mitigate osteoarthritis pathogenesis in mice. However, the underlying mechanism is…”
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Correction to: Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model by Leong, Daniel J, Choudhury, Marwa, Hanstein, Regina, Hirsh, David M, Kim, Sun Jin, Majeska, Robert J, Schaffler, Mitchell B, Hardin, John A, Spray, David C, Goldring, Mary B, Cobelli, Neil J, Sun, Hui B

“…Following publication of the original article [1], the authors reported an error in Figs. 2C and 5C…”
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Acid ceramidase maintains the chondrogenic phenotype of expanded primary chondrocytes and improves the chondrogenic differentiation of bone marrow-derived mesenchymal stem cells by Simonaro, Calogera M, Sachot, Sylvain, Ge, Yi, He, Xingxuan, Deangelis, Victor A, Eliyahu, Efrat, Leong, Daniel J, Sun, Hui B, Mason, Jeffrey B, Haskins, Mark E, Richardson, Dean W, Schuchman, Edward H

“…Acid ceramidase is required to maintain the metabolic balance of several important bioactive lipids, including ceramide, sphingosine and…”
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Matrix metalloproteinase-3 in articular cartilage is upregulated by joint immobilization and suppressed by passive joint motion by Leong, Daniel J., Gu, Xiang I., Li, Yonghui, Lee, Jonathan Y., Laudier, Damien M., Majeska, Robert J., Schaffler, Mitchell B., Cardoso, Luis, Sun, Hui B.

“…Both underloading and overloading of joints can lead to articular cartilage degradation, a process mediated in part by matrix metalloproteinases (MMPs). Here…”
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Moderate joint loading reduces degenerative actions of matrix metalloproteinases in the articular cartilage of mouse ulnae by Sun, Hui B, Zhao, Liming, Tanaka, Shigeo, Yokota, Hiroki

“…Joint loading is a recently developed loading modality, which can enhance bone formation and accelerate healing of bone fracture. Since mechanical stimulation…”
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