Search Results - "Sun, Hui‐Chuan"

Emerging agents and regimens for hepatocellular carcinoma by Zhu, Xiao-Dong, Sun, Hui-Chuan

“…Liver cancer, mostly hepatocellular carcinoma (HCC), is the second leading cause of cancer mortality globally. Most patients need at least one systemic therapy…”
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Downstaging Conversion Therapy in Patients With Initially Unresectable Advanced Hepatocellular Carcinoma: An Overview by Sun, Hui-Chuan, Zhu, Xiao-Dong

“…The high mortality rate associated with hepatocellular carcinoma (HCC) is partly due to the high proportion of patients who present with advanced stage disease…”
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Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma by Sun, Yun-Fan, Wu, Liang, Liu, Shi-Ping, Jiang, Miao-Miao, Hu, Bo, Zhou, Kai-Qian, Guo, Wei, Xu, Yang, Zhong, Yu, Zhou, Xiao-Rui, Zhang, Ze-Fan, Liu, Geng, Liu, Sheng, Shi, Ying-Hong, Ji, Yuan, Du, Min, Li, Nan-Nan, Li, Gui-Bo, Zhao, Zhi-Kun, Huang, Xiao-Yun, Xu, Li-Qin, Yu, Qi-Chao, Peng, David H., Qiu, Shuang-Jian, Sun, Hui-Chuan, Dean, Michael, Wang, Xiang-Dong, Chung, Wen-Yuan, Dennison, Ashley R., Zhou, Jian, Hou, Yong, Fan, Jia, Yang, Xin-Rong

“…Little is known about the transcriptomic plasticity and adaptive mechanisms of circulating tumor cells (CTCs) during hematogeneous dissemination. Here we…”
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Integrated Metabolite and Gene Expression Profiles Identify Lipid Biomarkers Associated With Progression of Hepatocellular Carcinoma and Patient Outcomes by Budhu, Anuradha, Roessler, Stephanie, Zhao, Xuelian, Yu, Zhipeng, Forgues, Marshonna, Ji, Junfang, Karoly, Edward, Qin, Lun–Xiu, Ye, Qing–Hai, Jia, Hu–Liang, Fan, Jia, Sun, Hui–Chuan, Tang, Zhao–You, Wang, Xin Wei

“…Background & Aims We combined gene expression and metabolic profiling analyses to identify factors associated with outcomes of patients with hepatocellular…”
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Depletion of Tumor-Associated Macrophages Enhances the Effect of Sorafenib in Metastatic Liver Cancer Models by Antimetastatic and Antiangiogenic Effects by WEI ZHANG, ZHU, Xiao-Dong, SUN, Hui-Chuan, XIONG, Yu-Quan, ZHUANG, Peng-Yuan, XU, Hua-Xiang, KONG, Ling-Qun, LU WANG, WU, Wei-Zhong, TANG, Zhao-You

“…To investigate the role of macrophages in tumor progression under sorafenib treatment and to explore whether combination of drugs that deplete macrophages…”
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miR-182-5p promotes hepatocellular carcinoma progression by repressing FOXO3a by Cao, Man-Qing, You, A-Bin, Zhu, Xiao-Dong, Zhang, Wei, Zhang, Yuan-Yuan, Zhang, Shi-Zhe, Zhang, Ke-Wei, Cai, Hao, Shi, Wen-Kai, Li, Xiao-Long, Li, Kang-Shuai, Gao, Dong-Mei, Ma, De-Ning, Ye, Bo-Gen, Wang, Cheng-Hao, Qin, Cheng-Dong, Sun, Hui-Chuan, Zhang, Ti, Tang, Zhao-You

“…High frequency of recurrence is the major cause of the poor outcomes for patients with hepatocellular carcinoma (HCC). microRNA (miR)-182-5p emerged as a…”
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An Eastern Hepatobiliary Surgery Hospital Microvascular Invasion Scoring System in Predicting Prognosis of Patients with Hepatocellular Carcinoma and Microvascular Invasion After R0 Liver Resection: A Large‐Scale, Multicenter Study by Zhang, Xiu‐Ping, Wang, Kang, Wei, Xu‐Biao, Li, Le‐Qun, Sun, Hui‐Chuan, Wen, Tian‐Fu, Chai, Zong‐Tao, Chen, Zhen‐Hua, Shi, Jie, Guo, Wei‐Xing, Xie, Dong, Cong, Wen‐Ming, Wu, Meng‐Chao, Lau, Wan Yee, Cheng, Shu‐Qun

“…Background Microvascular invasion (MVI) is associated with poor postoperative survival outcomes in patients with hepatocellular carcinoma (HCC). An Eastern…”
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High Expression of Macrophage Colony-Stimulating Factor in Peritumoral Liver Tissue Is Associated With Poor Survival After Curative Resection of Hepatocellular Carcinoma by ZHU, Xiao-Dong, ZHANG, Ju-Bo, ZHUANG, Peng-Yuan, ZHU, Hong-Guang, WEI ZHANG, XIONG, Yu-Quan, WU, Wei-Zhong, LU WANG, TANG, Zhao-You, SUN, Hui-Chuan

“…To investigate prognostic values of the intratumoral and peritumoral expression of macrophage colony-stimulating factors (M-CSF) in hepatocellular carcinoma…”
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Lymphoid‐specific helicase promotes the growth and invasion of hepatocellular carcinoma by transcriptional regulation of centromere protein F expression by Yang, Xuan, Miao, Bi‐Si, Wei, Chuan‐Yuan, Dong, Rui‐Zhao, Gao, Ping‐Ting, Zhang, Xin‐Yu, Lu, Jia‐Cheng, Gao, Chao, Wang, Xiao‐Ying, Sun, Hui‐Chuan, Zhou, Jian, Fan, Jia, Ke, Ai‐Wu, Shi, Guo‐Ming, Cai, Jia‐Bin

“…Lymphoid‐specific helicase (LSH) is overexpressed in tumor tissues and its overexpression is associated with poor prognosis in several cancers. However, the…”
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Adjuvant therapies after curative treatments for hepatocellular carcinoma: Current status and prospects by Zhu, Xiao-Dong, Li, Kang-Shuai, Sun, Hui-Chuan

“…Tumor recurrence rate after surgery or ablation of hepatocellular carcinoma (HCC) is as high as 70%. However, there are no widely accepted adjuvant therapies;…”
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Downstaging and Resection of Initially Unresectable Hepatocellular Carcinoma with Tyrosine Kinase Inhibitor and Anti-PD-1 Antibody Combinations by Zhu, Xiao-Dong, Huang, Cheng, Shen, Ying-Hao, Ji, Yuan, Ge, Ning-Ling, Qu, Xu-Dong, Chen, Lingli, Shi, Wen-Kai, Li, Mei-Ling, Zhu, Jin-Jin, Tan, Chang-Jun, Tang, Zhao-You, Zhou, Jian, Fan, Jia, Sun, Hui-Chuan

“…Background: Combined therapy with tyrosine kinase inhibitors (TKIs) and anti-PD-1 antibodies has shown high tumor response rates for patients with unresectable…”
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Cross talk between oxidative stress and hypoxia via thioredoxin and HIF‐2α drives metastasis of hepatocellular carcinoma by Cao, Man‐Qing, You, A‐Bin, Cui, Wei, Zhang, Su, Guo, Zhi‐Gui, Chen, Lu, Zhu, Xiao‐Dong, Zhang, Wei, Zhu, Xiao‐Lin, Guo, Hua, Deng, Da‐Jun, Sun, Hui‐Chuan, Zhang, Ti

“…Oxidative stress and hypoxia are two opposite microenvironments involved in HCC metastasis. Thioredoxin (TXN) and hypoxia‐inducible factor 2α (HIF‐2α) are…”
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Sorafenib Down-regulates Expression of HTATIP2 to Promote Invasiveness and Metastasis of Orthotopic Hepatocellular Carcinoma Tumors in Mice by Zhang, Wei, Sun, Hui–Chuan, Wang, Wen–Quan, Zhang, Qiang–Bo, Zhuang, Peng–Yuan, Xiong, Yu–Quan, Zhu, Xiao–Dong, Xu, Hua–Xiang, Kong, Ling–Qun, Wu, Wei–Zhong, Wang, Lu, Song, Tian–Qiang, Li, Qiang, Tang, Zhao–You

“…Background & Aims Antiangiogenic agents can sometimes promote tumor invasiveness and metastasis, but little is known about the effects of the antiangiogenic…”
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Hazard rate for postoperative recurrence in patients with hepatocellular carcinoma at Barcelona Clinic Liver Cancer stage 0 or A1: A multicenter observational study by Xiang, Yan‐Jun, Wang, Kang, Yu, Hong‐Ming, Wang, Miao‐Miao, Li, Le‐Qun, Sun, Hui‐Chuan, Wen, Tian‐Fu, Zhang, Yu‐Qing, Shan, Yun‐Feng, Zhou, Li‐Ping, Cheng, Shu‐Qun

“…Aim Surgical treatment is the first‐line treatment for patients with Barcelona Clinic Liver Cancer (BCLC) stage 0 or A1 hepatocellular carcinoma (HCC), and…”
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Staging, prognostic factors and adjuvant therapy of intrahepatic cholangiocarcinoma after curative resection by Li, Tao, Qin, Lun-Xiu, Zhou, Jian, Sun, Hui-Chuan, Qiu, Shuang-Jian, Ye, Qing-Hai, Wang, Lu, Tang, Zhao-You, Fan, Jia

“…Background & Aims Prognostic factors and adjuvant therapy of intrahepatic cholangiocarcinoma (ICC) after curative resection were not clear. We aim to analyse…”
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miR-612 suppresses the invasive-metastatic cascade in hepatocellular carcinoma by Tao, Zhong-Hua, Wan, Jin-Liang, Zeng, Ling-Yao, Xie, Lu, Sun, Hui-Chuan, Qin, Lun-Xiu, Wang, Lu, Zhou, Jian, Ren, Zheng-Gang, Li, Yi-Xue, Fan, Jia, Wu, Wei-Zhong

“…MicroRNAs (miRNAs) play a critical role in tumor metastasis. In this study, we identified a set of 32 miRNAs involved in hepatocellular carcinoma (HCC)…”
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Toripalimab combined with lenvatinib and GEMOX is a promising regimen as first-line treatment for advanced intrahepatic cholangiocarcinoma: a single-center, single-arm, phase 2 study by Shi, Guo-Ming, Huang, Xiao-Yong, Wu, Dong, Sun, Hui-Chuan, Liang, Fei, Ji, Yuan, Chen, Yi, Yang, Guo-Huan, Lu, Jia-Cheng, Meng, Xian-Long, Wang, Xin-Ying, Sun, Lei, Ge, Ning-Ling, Huang, Xiao-Wu, Qiu, Shuang-Jian, Yang, Xin-Rong, Gao, Qiang, He, Yi-Feng, Xu, Yang, Sun, Jian, Ren, Zheng-Gang, Fan, Jia, Zhou, Jian

“…Advanced intrahepatic cholangiocarcinoma (ICC) has a dismal prognosis. Here, we report the efficacy and safety of combining toripalimab, lenvatinib, and…”
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MiR-146a enhances angiogenic activity of endothelial cells in hepatocellular carcinoma by promoting PDGFRA expression by Zhu, Kai, Pan, Qi, Zhang, Xin, Kong, Ling-Qun, Fan, Jia, Dai, Zhi, Wang, Lu, Yang, Xin-Rong, Hu, Jie, Wan, Jin-Liang, Zhao, Yi-Ming, Tao, Zhong-Hua, Chai, Zong-Tao, Zeng, Hai-Ying, Tang, Zhao-You, Sun, Hui-Chuan, Zhou, Jian

“…Endothelial cells (ECs) are critical for angiogenesis, and microRNAs play important roles in this process. We investigated the regulatory role of microRNAs in…”
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MicroRNA-26a inhibits angiogenesis by down-regulating VEGFA through the PIK3C2α/Akt/HIF-1α pathway in hepatocellular carcinoma by Chai, Zong-Tao, Kong, Jian, Zhu, Xiao-Dong, Zhang, Yuan-Yuan, Lu, Lu, Zhou, Jia-Min, Wang, Long-Rong, Zhang, Ke-Zhi, Zhang, Qiang-Bo, Ao, Jian-Yang, Wang, Miao, Wu, Wei-Zhong, Wang, Lu, Tang, Zhao-You, Sun, Hui-Chuan

“…microRNAs (miRNAs) have been reported to regulate angiogenesis by down-regulating the expression of pro-angiogenic or anti-angiogenic factors. The aims of this…”
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Immunotherapy in hepatocellular carcinoma: evaluation and management of adverse events associated with atezolizumab plus bevacizumab by Hsu, Chiun, Rimassa, Lorenza, Sun, Hui-Chuan, Vogel, Arndt, Kaseb, Ahmed O.

“…In light of positive efficacy and safety findings from the IMbrave150 trial of atezolizumab plus bevacizumab, this novel combination has become the preferred…”
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