Search Results - "Sun, Hongyin"
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Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction
Published in Nature communications (14-04-2020)“…Small molecule inhibitor of the bromodomain and extraterminal domain (BET) family proteins is a promising option for cancer treatment. However, current BET…”
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CECR2 drives breast cancer metastasis by promoting NF-κB signaling and macrophage-mediated immune suppression
Published in Science translational medicine (02-02-2022)“…Metastasis is the major cause of cancer-related deaths due to the lack of effective therapies. Emerging evidence suggests that certain epigenetic and…”
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Discovery of WD-890: A novel allosteric TYK2 inhibitor for the treatment of multiple autoimmune diseases
Published in Biomedicine & pharmacotherapy (01-11-2023)“…Tyrosine kinase 2 (TYK2) as a member of Janus kinase (JAK) family, mainly mediates the signaling of type I interferons (IFN), interleukin-12 (IL-12) and…”
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Editorial: Epigenetic Regulation and Tumor Immunotherapy
Published in Frontiers in oncology (05-05-2022)Get full text
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eEF2K promotes PD-L1 stabilization through inactivating GSK3β in melanoma
Published in Journal for immunotherapy of cancer (01-03-2022)“…Immune checkpoint blockade (ICB) targeting programmed death ligand-1 (PD-L1)/programmed cell death protein-1 (PD-1) pathway has become an attractive strategy…”
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A Distributed SoC Balancing Control Method for Series-type Energy Storage System in Grid-connected Mode
Published in 2022 Asia Conference on Algorithms, Computing and Machine Learning (CACML) (01-03-2022)“…Energy storage system (ESS) equipped with power electronics plays an essential role in renewable energy integration. Series-type energy storage system (SESS)…”
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Conference Proceeding -
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Interleukin-1 receptor antagonist improves normoglycemia and insulin sensitivity in diabetic Goto-Kakizaki-rats
Published in European journal of pharmacology (15-02-2013)“…Type 2 diabetes mellitus has been considered as an auto-inflammatory syndrome. Interleukin-1 receptor antagonist (IL-1Ra) has attained considerable attention…”
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Tumour vasculature at single-cell resolution
Published in Nature (London) (08-08-2024)“…Tumours can obtain nutrients and oxygen required to progress and metastasize through the blood supply 1 . Inducing angiogenesis involves the sprouting of…”
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BRD4 inhibitor suppresses melanoma metastasis via the SPINK6/EGFR-EphA2 pathway
Published in Pharmacological research (01-01-2023)“…BET inhibition or BRD4 depletion is a promising and attractive therapy for metastatic melanoma; however, the mechanism is still unclear. Here, we indicated…”
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Single-Cell Profiling Reveals Sustained Immune Infiltration, Surveillance, and Tumor Heterogeneity in Infiltrative Basal Cell Carcinoma
Published in Journal of investigative dermatology (01-11-2023)“…Infiltrative basal cell carcinoma (iBCC) is a particularly aggressive subtype of basal cell carcinoma that tends to progress and recur after surgery, and its…”
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Combined BET and MEK Inhibition synergistically suppresses melanoma by targeting YAP1
Published in Theranostics (2024)“…The response rate to the MEK inhibitor trametinib in BRAF-mutated melanoma patients is less than 30%, and drug resistance develops rapidly, but the mechanism…”
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Speech enhancement using orthogonal matching pursuit algorithm
Published in 2014 International Conference on Orange Technologies (01-09-2014)“…This paper proposes a novel approach for speech enhancement based on compressed sensing (CS) theory. Each frame of noisy speech signal is sparsified firstly by…”
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Conference Proceeding