Search Results - "Sun, Duxin"

Why 90% of clinical drug development fails and how to improve it? by Sun, Duxin, Gao, Wei, Hu, Hongxiang, Zhou, Simon

“…Ninety percent of clinical drug development fails despite implementation of many successful strategies, which raised the question whether certain aspects in…”
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Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer by Li, Wei, Tanikawa, Takashi, Kryczek, Ilona, Xia, Houjun, Li, Gaopeng, Wu, Ke, Wei, Shuang, Zhao, Lili, Vatan, Linda, Wen, Bo, Shu, Pan, Sun, Duxin, Kleer, Celina, Wicha, Max, Sabel, Michael, Tao, Kaixiong, Wang, Guobin, Zou, Weiping

“…Myeloid-derived suppressor cells (MDSCs) inhibit anti-tumor immunity. Aerobic glycolysis is a hallmark of cancer. However, the link between MDSCs and…”
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Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis by Das, Nupur K., Schwartz, Andrew J., Barthel, Gabrielle, Inohara, Naohiro, Liu, Qing, Sankar, Amanda, Hill, David R., Ma, Xiaoya, Lamberg, Olivia, Schnizlein, Matthew K., Arqués, Juan L., Spence, Jason R., Nunez, Gabriel, Patterson, Andrew D., Sun, Duxin, Young, Vincent B., Shah, Yatrik M.

“…Iron is a central micronutrient needed by all living organisms. Competition for iron in the intestinal tract is essential for the maintenance of indigenous…”
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Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression by Qin, Chong, Hu, Yang, Zhou, Bing, Fernandez-Salas, Ester, Yang, Chao-Yie, Liu, Liu, McEachern, Donna, Przybranowski, Sally, Wang, Mi, Stuckey, Jeanne, Meagher, Jennifer, Bai, Longchuan, Chen, Zhuo, Lin, Mei, Yang, Jiuling, Ziazadeh, Danya N, Xu, Fuming, Hu, Jiantao, Xiang, Weiguo, Huang, Liyue, Li, Siwei, Wen, Bo, Sun, Duxin, Wang, Shaomeng

“…Proteins of the bromodomain and extra-terminal (BET) family are epigenetics “readers” and promising therapeutic targets for cancer and other human diseases. We…”
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Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein by Zhou, Haibin, Bai, Longchuan, Xu, Renqi, Zhao, Yujun, Chen, Jianyong, McEachern, Donna, Chinnaswamy, Krishnapriya, Wen, Bo, Dai, Lipeng, Kumar, Praveen, Yang, Chao-Yie, Liu, Zhaomin, Wang, Mi, Liu, Liu, Meagher, Jennifer L, Yi, Han, Sun, Duxin, Stuckey, Jeanne A, Wang, Shaomeng

“…Signal transducer and activator of transcription 3 (STAT3) is a transcription factor and an attractive therapeutic target for cancer and other human diseases…”
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Tumor-derived exosomes: Nanovesicles made by cancer cells to promote cancer metastasis by Chen, Hongwei, Chengalvala, Venkata, Hu, Hongxiang, Sun, Duxin

“…Nanomedicine usually refers to nanoparticles that deliver the functional drugs and siRNAs to treat cancer. Recent research has suggested that cancer cells can…”
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Multiparameter Optimization of Oxidative Phosphorylation Inhibitors for the Treatment of Pancreatic Cancer by Xue, Ding, Xu, Yibin, Kyani, Armita, Roy, Joyeeta, Dai, Lipeng, Sun, Duxin, Neamati, Nouri

“…Targeting oxidative phosphorylation (OXPHOS) complexes is an emerging strategy to disrupt the metabolism of select cancer subtypes and to overcome resistance…”
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Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer by Bai, Longchuan, Zhou, Bing, Yang, Chao-Yie, Ji, Jiao, McEachern, Donna, Przybranowski, Sally, Jiang, Hui, Hu, Jiantao, Xu, Fuming, Zhao, Yujun, Liu, Liu, Fernandez-Salas, Ester, Xu, Jing, Dou, Yali, Wen, Bo, Sun, Duxin, Meagher, Jennifer, Stuckey, Jeanne, Hayes, Daniel F, Li, Shunqiang, Ellis, Matthew J, Wang, Shaomeng

“…Triple-negative breast cancers (TNBC) remain clinically challenging with a lack of options for targeted therapy. In this study, we report the development of a…”
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Discovery and Lead Optimization of Benzene-1,4-disulfonamides as Oxidative Phosphorylation Inhibitors by Xue, Ding, Xu, Yibin, Kyani, Armita, Roy, Joyeeta, Dai, Lipeng, Sun, Duxin, Neamati, Nouri

“…Inhibition of oxidative phosphorylation (OXPHOS) is a promising therapeutic strategy for select cancers that are dependent on aerobic metabolism. Here, we…”
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Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome by Rom, Oren, Liu, Yuhao, Liu, Zhipeng, Zhao, Ying, Wu, Jianfeng, Ghrayeb, Alia, Villacorta, Luis, Fan, Yanbo, Chang, Lin, Wang, Lu, Liu, Cai, Yang, Dongshan, Song, Jun, Rech, Jason C, Guo, Yanhong, Wang, Huilun, Zhao, Guizhen, Liang, Wenying, Koike, Yui, Lu, Haocheng, Koike, Tomonari, Hayek, Tony, Pennathur, Subramaniam, Xi, Chuanwu, Wen, Bo, Sun, Duxin, Garcia-Barrio, Minerva T, Aviram, Michael, Gottlieb, Eyal, Mor, Inbal, Liu, Wanqing, Zhang, Jifeng, Chen, Y Eugene

“…Nonalcoholic fatty liver disease (NAFLD) including nonalcoholic steatohepatitis (NASH) has reached epidemic proportions with no pharmacological therapy…”
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A Potent Small-Molecule Inhibitor of the MDM2–p53 Interaction (MI-888) Achieved Complete and Durable Tumor Regression in Mice by Zhao, Yujun, Yu, Shanghai, Sun, Wei, Liu, Liu, Lu, Jianfeng, McEachern, Donna, Shargary, Sanjeev, Bernard, Denzil, Li, Xiaoqin, Zhao, Ting, Zou, Peng, Sun, Duxin, Wang, Shaomeng

“…We previously reported the discovery of a class of spirooxindoles as potent and selective small-molecule inhibitors of the MDM2–p53 interaction (MDM2…”
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ASGARD is A Single-cell Guided Pipeline to Aid Repurposing of Drugs by He, Bing, Xiao, Yao, Liang, Haodong, Huang, Qianhui, Du, Yuheng, Li, Yijun, Garmire, David, Sun, Duxin, Garmire, Lana X.

“…Single-cell RNA sequencing technology has enabled in-depth analysis of intercellular heterogeneity in various diseases. However, its full potential for…”
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Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells by YANYAN LI, TAO ZHANG, DUXIN SUN, KORKAYA, Hasan, SULING LIU, LEE, Hsiu-Fang, NEWMAN, Bryan, YANKE YU, CLOUTHIER, Shawn G, SCHWARTZ, Steven J, WICHA, Max S

“…The existence of cancer stem cells (CSCs) in breast cancer has profound implications for cancer prevention. In this study, we evaluated sulforaphane, a natural…”
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Sulforaphane Enhances the Anticancer Activity of Taxanes against Triple Negative Breast Cancer by Killing Cancer Stem Cells by Burnett, Joseph P, Lim, Gi, Li, Yanyan, Shah, Ronak B, Lim, Rebekah, Paholak, Hayley J, McDermott, Sean P, Sun, Lichao, Tsume, Yasuhiro, Bai, Shuhua, Wicha, Max S, Sun, Duxin, Zhang, Tao

“…Abstract Triple negative breast cancer (TNBC) typically exhibits rapid progression, high mortality and faster relapse rates relative to other breast cancer…”
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Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo by Borkin, Dmitry, He, Shihan, Miao, Hongzhi, Kempinska, Katarzyna, Pollock, Jonathan, Chase, Jennifer, Purohit, Trupta, Malik, Bhavna, Zhao, Ting, Wang, Jingya, Wen, Bo, Zong, Hongliang, Jones, Morgan, Danet-Desnoyers, Gwenn, Guzman, Monica L., Talpaz, Moshe, Bixby, Dale L., Sun, Duxin, Hess, Jay L., Muntean, Andrew G., Maillard, Ivan, Cierpicki, Tomasz, Grembecka, Jolanta

“…Chromosomal translocations affecting mixed lineage leukemia gene (MLL) result in acute leukemias resistant to therapy. The leukemogenic activity of MLL fusion…”
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Therapeutic targeting of TP53-mutated acute myeloid leukemia by inhibiting HIF-1α with echinomycin by Wang, Yin, Liu, Yan, Bailey, Christopher, Zhang, Huixia, He, Miao, Sun, Duxin, Zhang, Peng, Parkin, Brian, Baer, Maria R., Zheng, Pan, Malek, Sami N., Liu, Yang

“…TP53 mutation in acute myeloid leukemia (AML) is associated with poor prognosis. Since no targeted therapy is available to restore p53 function, it is of great…”
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Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity by Rogawski, David S., Deng, Jing, Li, Hao, Miao, Hongzhi, Borkin, Dmitry, Purohit, Trupta, Song, Jiho, Chase, Jennifer, Li, Shuangjiang, Ndoj, Juliano, Klossowski, Szymon, Kim, EunGi, Mao, Fengbiao, Zhou, Bo, Ropa, James, Krotoska, Marta Z., Jin, Zhuang, Ernst, Patricia, Feng, Xiaomin, Huang, Gang, Nishioka, Kenichi, Kelly, Samantha, He, Miao, Wen, Bo, Sun, Duxin, Muntean, Andrew, Dou, Yali, Maillard, Ivan, Cierpicki, Tomasz, Grembecka, Jolanta

“…ASH1L histone methyltransferase plays a crucial role in the pathogenesis of different diseases, including acute leukemia. While ASH1L represents an attractive…”
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Characterization of Celastrol to Inhibit Hsp90 and Cdc37 Interaction by Zhang, Tao, Li, Yanyan, Yu, Yanke, Zou, Peng, Jiang, Yiqun, Sun, Duxin

“…The molecular chaperone heat shock protein 90 (Hsp90) is required for the stabilization and conformational maturation of various oncogenic proteins in cancer…”
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Engineering exosomes as refined biological nanoplatforms for drug delivery by Luan, Xin, Sansanaphongpricha, Kanokwan, Myers, Ila, Chen, Hongwei, Yuan, Hebao, Sun, Duxin

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A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo by Abulwerdi, Fardokht, Liao, Chenzhong, Liu, Meilan, Azmi, Asfar S, Aboukameel, Amro, Mady, Ahmed S A, Gulappa, Thippeswamy, Cierpicki, Tomasz, Owens, Scott, Zhang, Tao, Sun, Duxin, Stuckey, Jeanne A, Mohammad, Ramzi M, Nikolovska-Coleska, Zaneta

“…Using a high-throughput screening (HTS) approach, we have identified and validated several small-molecule Mcl-1 inhibitors (SMI). Here, we describe a novel…”
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