Search Results - "Sun, Beicheng"

Targeting cancer-promoting inflammation — have anti-inflammatory therapies come of age? by Hou, Jiajie, Karin, Michael, Sun, Beicheng

“…The immune system has crucial roles in cancer development and treatment. Whereas adaptive immunity can prevent or constrain cancer through immunosurveillance,…”
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The immunobiology of hepatocellular carcinoma in humans and mice: Basic concepts and therapeutic implications by Hou, Jiajie, Zhang, Haiyan, Sun, Beicheng, Karin, Michael

“…Basic and clinical studies have demonstrated the efficacy of immunotherapy, a technical and conceptual breakthrough that has revolutionised cancer treatment…”
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IL-33/ST2 signaling in liver transplantation by Tan, Zhongming, Sun, Beicheng

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Listeria-based hepatocellular carcinoma vaccine facilitates anti-PD-1 therapy by regulating macrophage polarization by Xu, Guolong, Feng, Dongju, Yao, Yao, Li, Peipei, Sun, Hua, Yang, Hong, Li, Changxian, Jiang, Runqiu, Sun, Beicheng, Chen, Yun

“…Recently, patients with advanced cancers have been benefited greatly from immune checkpoint blockade immunotherapy. However, immune checkpoint blockade is…”
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YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma by Hou, Jiajie, Zhang, He, Liu, Jun, Zhao, Zhenjun, Wang, Jianye, Lu, Zhike, Hu, Bian, Zhou, Jiankui, Zhao, Zhicong, Feng, Mingxuan, Zhang, Haiyan, Shen, Bin, Huang, Xingxu, Sun, Beicheng, Smyth, Mark J, He, Chuan, Xia, Qiang

“…Dynamic N -methyladenosine (m A) modification was previously identified as a ubiquitous post-transcriptional regulation that affected mRNA homeostasis…”
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VersicanV1 promotes proliferation and metastasis of hepatocellular carcinoma through the activation of EGFR–PI3K–AKT pathway by Zhangyuan, Guangyan, Wang, Fei, Zhang, Haitian, Jiang, Runqiu, Tao, Xuewen, Yu, Decai, Jin, Kangpeng, Yu, WeiWei, Liu, Yang, Yin, Yin, Shen, Jintao, Xu, Qinfeng, Zhang, Wenjie, Sun, Beicheng

“…Versican has been reported to participate in carcinogenesis in several malignant tumors. However, the accurate role of VersicanV1, a predominant isoform of…”
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The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion by Jiang, Runqiu, Tang, Junwei, Chen, Yun, Deng, Lei, Ji, Jie, Xie, Yu, Wang, Ke, Jia, Wei, Chu, Wen-Ming, Sun, Beicheng

“…Long noncoding RNAs play a pivotal role in T-helper cell development but little is known about their roles in Treg differentiation and functions during the…”
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IL-17A plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation by Tan, Zhongming, Qian, Xiaofeng, Jiang, Runqiu, Liu, Qianghui, Wang, Youjing, Chen, Chen, Wang, Xuehao, Ryffel, Bernhard, Sun, Beicheng

“…Liver fibrosis is a severe, life-threatening clinical condition resulting from nonresolving hepatitis of different origins. IL-17A is critical in inflammation,…”
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HULC and Linc00152 Act as Novel Biomarkers in Predicting Diagnosis of Hepatocellular Carcinoma by Li, Jun, Wang, Xiaochen, Tang, Junwei, Jiang, Runqiu, Zhang, Wenjie, Ji, Jie, Sun, Beicheng

“…Background/Aims: The alterations of long non-coding RNAs (lncRNAs) are related to multiple diseases. They can be detected in plasma as biomarkers for the…”
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LINC00152 promotes proliferation in hepatocellular carcinoma by targeting EpCAM via the mTOR signaling pathway by Ji, Jie, Tang, Junwei, Deng, Lei, Xie, Yu, Jiang, Runqiu, Li, Guoqiang, Sun, Beicheng

“…Hepatocellular carcinoma (HCC) is well known as the sixth most common malignant tumor and the third leading cause of cancer-related deaths globally. LINC00152…”
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The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation by Zhang, Wenjie, Zhangyuan, Guangyan, Wang, Fei, Jin, Kangpeng, Shen, Haiyuan, Zhang, Liansheng, Yuan, Xiang, Wang, Jincheng, Zhang, Haitian, Yu, Weiwei, Huang, Ruyi, Xu, Xiaoliang, Yin, Yin, Zhong, Guisheng, Lin, Anning, Sun, Beicheng

“…Chronic inflammation plays a central role in hepatocellular carcinoma (HCC), but the contribution of hepatocytes to tumor-associated inflammation is not clear…”
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Plasma miRNAs as early biomarkers for detecting hepatocellular carcinoma by Wen, Yang, Han, Jing, Chen, Jianguo, Dong, Jing, Xia, Yongxiang, Liu, Jibin, Jiang, Yue, Dai, Juncheng, Lu, Jianhua, Jin, Guangfu, Han, Jiali, Wei, Qingyi, Shen, Hongbing, Sun, Beicheng, Hu, Zhibin

“…The early detection of hepatocellular carcinoma (HCC) presents a challenge because of the lack of specific biomarkers. Serum/plasma microRNAs (miRNAs) can…”
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Interleukin‐22 promotes human hepatocellular carcinoma by activation of STAT3 by Jiang, Runqiu, Tan, Zhongming, Deng, Lei, Chen, Yun, Xia, Yongxiang, Gao, Yun, Wang, Xuehao, Sun, Beicheng

“…Interleukin‐22 (IL‐22), one of the cytokines secreted by T helper 17 (Th17) cells, was recently reported to be a novel inflammation driver through STAT3…”
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NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly by He, Feng, Antonucci, Laura, Yamachika, Shinichiro, Zhang, Zechuan, Taniguchi, Koji, Umemura, Atsushi, Hatzivassiliou, Georgia, Roose-Girma, Merone, Reina-Campos, Miguel, Duran, Angeles, Diaz-Meco, Maria T., Moscat, Jorge, Sun, Beicheng, Karin, Michael

“…Hepatomegaly can be triggered by insulin and insulin-unrelated etiologies. Insulin acts via AKT, but how other challenges cause hepatomegaly is unknown. Since…”
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The aberrant expression of MEG3 regulated by UHRF1 predicts the prognosis of hepatocellular carcinoma by Zhuo, Han, Tang, Junwei, Lin, Zhe, Jiang, Runqiu, Zhang, Xudong, Ji, Jie, Wang, Ping, Sun, Beicheng

“…MEG3 as a tumor suppressor has been reported to be linked with pathogenesis of malignancies including hepatocellular carcinoma (HCC). However, the mechanism of…”
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Ursodeoxycholic acid accelerates bile acid enterohepatic circulation by Zhang, Yunjing, Jiang, Runqiu, Zheng, Xiaojiao, Lei, Sha, Huang, Fengjie, Xie, Guoxiang, Kwee, Sandi, Yu, Herbert, Farrar, Christine, Sun, Beicheng, Zhao, Aihua, Jia, Wei

“…Background and Purpose Ursodeoxycholic acid (UDCA) is the first‐line treatment for primary biliary cholangitis, but its effects on the enterohepatic…”
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NF-κB-p62-NRF2 survival signaling is associated with high ROR1 expression in chronic lymphocytic leukemia by Sanchez-Lopez, Elsa, Ghia, Emanuela M., Antonucci, Laura, Sharma, Natasha, Rassenti, Laura Z., Xu, Jinyi, Sun, Beicheng, Kipps, Thomas J., Karin, Michael

“…Progression of chronic lymphocytic leukemia (CLL) and resistance to therapy are affected by tumor microenvironmental factors. One such factor is B-cell…”
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CUG-binding protein 1 regulates HSC activation and liver fibrogenesis by Wu, Xingxin, Wu, Xudong, Ma, Yuxiang, Shao, Fenli, Tan, Yang, Tan, Tao, Gu, Liyun, Zhou, Yang, Sun, Beicheng, Sun, Yang, Wu, Xuefeng, Xu, Qiang

“…Excessive activation of hepatic stellate cells (HSCs) is a key step in liver fibrogenesis. Here we report that CUG-binding protein 1 (CUGBP1) expression is…”
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DCAF1 interacts with PARD3 to promote hepatocellular carcinoma progression and metastasis by activating the Akt signaling pathway by Zhang, Jinyao, Shi, Yuze, Ding, Ke, Yu, Weiwei, He, Jianbo, Sun, Beicheng

“…Hepatocellular carcinoma (HCC) is a fatal malignancy with poor prognosis due to lack of effective clinical interference. DCAF1 plays a vital role in regulating…”
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Down-Regulation of LncRNA DGCR5 Correlates with Poor Prognosis in Hepatocellular Carcinoma by Huang, Ruyi, Wang, Xiaochen, Zhang, Wenjie, Zhangyuan, Guangyan, Jin, Kangpeng, Yu, Weiwei, Xie, Yu, Xu, Xiaoliang, Wang, Hai, Sun, Beicheng

“…Background/Aims: Long non-coding RNAs (lncRNAs) have been reported to play pivotal roles in multiple tumors and can act as tumor biomarkers. In this study, we…”
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