Search Results - "Sumner, Susan C J"

Metabolomics reveals biomarkers of opioid use disorder by Ghanbari, Reza, Li, Yuanyuan, Pathmasiri, Wimal, McRitchie, Susan, Etemadi, Arash, Pollock, Jonathan D., Poustchi, Hossein, Rahimi-Movaghar, Afarin, Amin-Esmaeili, Masoumeh, Roshandel, Gholamreza, Shayanrad, Amaneh, Abaei, Behrouz, Malekzadeh, Reza, Sumner, Susan C. J.

“…Opioid use disorder (OUD) is diagnosed using the qualitative criteria defined by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition…”
Get full text

Baseline Serum Biomarkers Predict Response to a Weight Loss Intervention in Older Adults with Obesity: A Pilot Study by Lynch, David H, Rushing, Blake R, Pathmasiri, Wimal, McRitchie, Susan, Batchek, Dakota J, Petersen, Curtis L, Gross, Danae C, Sumner, Susan C J, Batsis, John A

“…Caloric restriction and aerobic and resistance exercise are safe and effective lifestyle interventions for achieving weight loss in the obese older population…”
Get full text

Kinetics of Elimination of Urinary Metabolites of Acrylamide in Humans by Fennell, Timothy R., Sumner, Susan C. J., Snyder, Rodney W., Burgess, Jason, Friedman, Marvin A.

“…Acrylamide (AM), used in the manufacture of polyacrylamide and grouting agents, is produced during the cooking of foods. Workplace exposure to AM can occur…”
Get full text

Patterns of infant fecal metabolite concentrations and social behavioral development in toddlers by Laue, Hannah E., Bauer, Julia A., Pathmasiri, Wimal, Sumner, Susan C. J., McRitchie, Susan, Palys, Thomas J., Hoen, Anne G., Madan, Juliette C., Karagas, Margaret R.

“…Background Gut-derived metabolites, products of microbial and host co-metabolism, may inform mechanisms underlying children’s neurodevelopment. We investigated…”
Get full text

Blood type biochemistry and human disease by Ewald, D. Rose, Sumner, Susan C.J.

“…Associations between blood type and disease have been studied since the early 1900s when researchers determined that antibodies and antigens are inherited. In…”
Get full text

Obesity Increases Mortality and Modulates the Lung Metabolome during Pandemic H1N1 Influenza Virus Infection in Mice by Milner, J Justin, Rebeles, Jenny, Dhungana, Suraj, Stewart, Delisha A, Sumner, Susan C J, Meyers, Matthew H, Mancuso, Peter, Beck, Melinda A

“…Obese individuals are at greater risk for hospitalization and death from infection with the 2009 pandemic H1N1 influenza virus (pH1N1). In this study,…”
Get full text

Comparison of Lysis and Detachment Sample Preparation Methods for Cultured Triple-Negative Breast Cancer Cells Using UHPLC-HRMS-Based Metabolomics by Rushing, Blake R, Schroder, Madison, Sumner, Susan C J

“…Dysregulation of cellular metabolism is now a well-recognized hallmark of cancer. Studies investigating the metabolic features of cancer cells have shed new…”
Get full text

Human microbiota, blood group antigens, and disease by Ewald, D. Rose, Sumner, Susan C.J.

“…Far from being just “bugs in our guts,” the microbiota interacts with the body in previously unimagined ways. Research into the genome and the microbiome has…”
Get full text

Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer by Fennell, Emily M J, Aponte-Collazo, Lucas J, Pathmasiri, Wimal, Rushing, Blake R, Barker, Natalie K, Partridge, Megan C, Li, Yuan-Yuan, White, Cody A, Greer, Yoshimi E, Herring, Laura E, Lipkowitz, Stanley, Sumner, Susan C J, Iwanowicz, Edwin J, Graves, Lee M

“…ClpP activators ONC201 and related small molecules (TR compounds, Madera Therapeutics), have demonstrated significant anti-cancer potential in and studies,…”
Get full text

Pharmacokinetics of Dibutylphthalate in Pregnant Rats by Fennell, Timothy R., Krol, Wojciech L., Sumner, Susan C. J., Snyder, Rodney W.

“…Dibutylphthalate (DBP) can cause adverse effects on the developing male reproductive tract when administered late in gestation to pregnant rats. The objectives…”
Get full text

Untargeted metabolomics on first trimester serum implicates metabolic perturbations associated with BMI in development of hypertensive disorders: a discovery study by Li, Yuanyuan, Pan, Ke, McRitchie, Susan L, Harville, Emily W, Sumner, Susan C J

“…Body mass index (BMI) in early pregnancy is a critical risk factor for hypertensive disorders of pregnancy (HDP). The pathobiology of the interplay between BMI…”
Get full text

Untargeted Metabolomics: Biochemical Perturbations in Golestan Cohort Study Opium Users Inform Intervention Strategies by Li, Yuan-Yuan, Ghanbari, Reza, Pathmasiri, Wimal, McRitchie, Susan, Poustchi, Hossein, Shayanrad, Amaneh, Roshandel, Gholamreza, Etemadi, Arash, Pollock, Jonathan D, Malekzadeh, Reza, Sumner, Susan C J

“…Over 50 million people worldwide are estimated to use opioids, of which ~30 million use opiates (opium and its derivatives). Use of opiates has been associated…”
Get full text

Distribution of carbon-14 labeled C60 ([14C]C60) in the pregnant and in the lactating dam and the effect of C60 exposure on the biochemical profile of urine by Sumner, Susan C. J., Fennell, Timothy R., Snyder, Rodney W., Taylor, George F., Lewin, Anita H.

“…This study was conducted to determine the distribution of [14C]C60 in the pregnant rat and fetuses, and in the lactating rat and offspring. Pregnant rats were…”
Get full text

Metabolites as biomarkers of adverse reactions following vaccination: A pilot study using nuclear magnetic resonance metabolomics by McClenathan, Bruce M, Stewart, Delisha A, Spooner, Christina E, Pathmasiri, Wimal W, Burgess, Jason P, McRitchie, Susan L, Choi, Y. Sammy, Sumner, Susan C.J

“…Highlights • Metabolomics is the study of the small-molecule metabolite profile of an organism. • Metabolomics may help identify individuals predisposed to…”
Get full text

Disposition of intravenously or orally administered silver nanoparticles in pregnant rats and the effect on the biochemical profile in urine by Fennell, Timothy R., Mortensen, Ninell P., Black, Sherry R., Snyder, Rodney W., Levine, Keith E., Poitras, Eric, Harrington, James M., Wingard, Christopher J., Holland, Nathan A., Pathmasiri, Wimal, Sumner, Susan C. J.

“…Few investigations have been conducted on the disposition and fate of silver nanoparticles (AgNP) in pregnancy. The distribution of a single dose of…”
Get full text

Role of Cytochrome P450 2E1 in the Metabolism of Acrylamide and Acrylonitrile in Mice by Sumner, Susan C. J, Fennell, Timothy R, Moore, Timothy A, Chanas, Brian, Gonzalez, Frank, Ghanayem, Burhan I

“…Acrylonitrile (AN) and acrylamide (AM) are commonly used in the synthesis of plastics and polymers. In rodents, AM and AN are metabolized to the epoxides…”
Get full text

Acrylamide: A Comparison of Metabolism and Hemoglobin Adducts in Rodents following Dermal, Intraperitoneal, Oral, or Inhalation Exposure by Sumner, Susan C. J., Williams, Carla C., Snyder, Rodney W., Krol, Wojciech L., Asgharian, Bahman, Fennell, Timothy R.

“…Acrylamide (AM), which is used to manufacture polymers, is carcinogenic and a reproductive and neurological toxicant. The objective of this study was to…”
Get full text

Reconstructing exposures from small samples using physiologically based pharmacokinetic models and multiple biomarkers by Mosquin, Paul L, Licata, Amy Collins, Liu, Bing, Sumner, Susan C J, Okino, Miles S

“…This study examines the use of physiologically based pharmacokinetic (PBPK) models for inferring exposure when the number of biomarker observations per…”
Get full text

Transforming Big Data into AI‐ready data for nutrition and obesity research by Thomas, Diana M., Knight, Rob, Gilbert, Jack A., Cornelis, Marilyn C., Gantz, Marie G., Burdekin, Kate, Cummiskey, Kevin, Sumner, Susan C. J., Pathmasiri, Wimal, Sazonov, Edward, Gabriel, Kelley Pettee, Dooley, Erin E., Green, Mark A., Pfluger, Andrew, Kleinberg, Samantha

“…Objective Big Data are increasingly used in obesity and nutrition research to gain new insights and derive personalized guidance; however, this data in raw…”
Get full text

Comparison of the Hemoglobin Adducts Formed by Administration of N-Methylolacrylamide and Acrylamide to Rats by Fennell, Timothy R., Snyder, Rodney W., Krol, Wojciech L., Sumner, Susan C. J.

“…Acrylamide (AM) and N-methylolacrylamide (NMA) are used in the formulation of grouting materials. AM undergoes metabolism to a reactive epoxide, glycidamide…”
Get full text