Search Results - "Sumner, S C"

Fecal metabolomics reveals products of dysregulated proteolysis and altered microbial metabolism in obesity-related osteoarthritis by Rushing, B.R., McRitchie, S., Arbeeva, L., Nelson, A.E., Azcarate-Peril, M.A., Li, Y.-Y., Qian, Y., Pathmasiri, W., Sumner, S.C.J., Loeser, R.F.

“…The objective of this exploratory study was to determine if perturbations in gut microbial composition and the gut metabolome could be linked to individuals…”
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Metabolism and disposition of 1-bromopropane in rats and mice following inhalation or intravenous administration by Garner, C.E., Sumner, S.C.J., Davis, J.G., Burgess, J.P., Yueh, Y., Demeter, J., Zhan, Q., Valentine, J., Jeffcoat, A.R., Burka, L.T., Mathews, J.M.

“…Workplace exposure to 1-bromopropane (1-BrP) can potentially occur during its use in spray adhesives, fats, waxes, and resins. 1-BrP may be used to replace…”
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CYP2E1-Catalyzed Oxidation Contributes to the Sperm Toxicity of 1-Bromopropane in Mice by Garner, C. Edwin, Sloan, C, Sumner, S.C.J, Burgess, J, Davis, J, Etheridge, A, Parham, A, Ghanayem, B.I

“…1-Bromopropane (1-BrP) induces dose- and time-dependent reproductive organ toxicity and reduced sperm motility in rodents. The contribution of cytochrome…”
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Integrating metabolomic signatures and psychosocial parameters in responsivity to an immersion treatment model for adolescent obesity by Pathmasiri, W., Pratt, K. J., Collier, D. N., Lutes, L. D., McRitchie, S., Sumner, S. C. J.

“…With childhood obesity tripling in the past two decades alone, developing effective treatment to promote long-term weight loss and maintenance is critical…”
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Glutathione conjugation of 1,2:3,4-diepoxybutane in human liver and rat and mouse liver and lung in vitro by BOOGAARD, P. J, SUMNER, S. C.-J, BOND, J. A

“…1,3-Butadiene (BD) has been classified as a probable human carcinogen based on sufficient evidence of a carcinogenic response in B6C3F1 mice and Sprague-Dawley…”
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Acrylamide: A Comparison of Metabolism and Hemoglobin Adducts in Rodents following Dermal, Intraperitoneal, Oral, or Inhalation Exposure by Sumner, Susan C. J., Williams, Carla C., Snyder, Rodney W., Krol, Wojciech L., Asgharian, Bahman, Fennell, Timothy R.

“…Acrylamide (AM), which is used to manufacture polymers, is carcinogenic and a reproductive and neurological toxicant. The objective of this study was to…”
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Disposition of [ring-U-14C]styrene in rats and mice exposed by recirculating nose-only inhalation by BOOGAARD, P. J, DE KLOE, K. P, SUMNER, S. C. J, VAN ELBURG, T. P. A, WONG, B. A

“…The disposition of styrene was studied in a group of 12 Sprague Dawley rats and two groups of 30 CD1 mice exposed separately to 160 ppm [ring-U-(14)C]styrene…”
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A physiological model for tert-amyl methyl ether and tert-amyl alcohol : Hypothesis testing of model structures by COLLINS, A. S, SUMNER, S. C. J, BORGHOFF, S. J, MEDINSKY, M. A

“…The oxygenate tert-amyl methyl ether (TAME) is a gasoline fuel additive used to reduce carbon monoxide in automobile emissions. To evaluate the relative health…”
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A model for the formation and removal of hemoglobin adducts by Fennell, T R, Sumner, S C, Walker, V E

“…Hemoglobin adducts formed by chemical carcinogens can be used as biomarkers of exposure. The kinetics of adduct formation and removal is complex and depends on…”
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Safety study of a subgingival delivery system by Dunkin, R T, Sumner, 3rd, C S, Hughes, W R

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An effectiveness study of a subgingival delivery system by Dunkin, R T, Sumner, 3rd, C S, Hughes, W R

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Characterization of phosphodiester adducts produced by the reaction of cyanoethylene oxide with nucleotides by Yates, J M, Fennell, T R, Turner, Jr, M J, Recio, L, Sumner, S C

“…Cyanoethylene oxide (CEO), a putative toxic and carcinogenic metabolite of acrylonitrile, is a direct-acting mutagen. The focus of this study was to elucidate…”
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Hepatic and pulmonary glutathione conjugation of 1,2:3,4-diepoxybutane in human, rat, and mouse in vitro by Boogaard, Pieter J., Sumner, Susan C.-J., Turner, Max J., Bond, James A.

“…1,3-Butadiene (BD) is a carcinogen in rats and mice. Previous in vitro studies showed that mouse liver microsomes formed 1,2-epoxy-3-butene (BMO) from BD and…”
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Identification of metabolites of carcinogens by 13C NMR spectroscopy by Fennell, T R, Sumner, S C

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Role of Cytochrome P450 2E1 in the Metabolism of Acrylamide and Acrylonitrile in Mice by Sumner, Susan C. J, Fennell, Timothy R, Moore, Timothy A, Chanas, Brian, Gonzalez, Frank, Ghanayem, Burhan I

“…Acrylonitrile (AN) and acrylamide (AM) are commonly used in the synthesis of plastics and polymers. In rodents, AM and AN are metabolized to the epoxides…”
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Characterization and quantitation of urinary metabolites of [1,2,3-13C]acrylamide in rats and mice using 13C nuclear magnetic resonance spectroscopy by SUMNER, S. C. J, MACNEELA, J. P, FENNELL, T. R

“…Acrylamide, widely used for the production of polymers and as a grouting agent, causes neurotoxic effects in humans and neurotoxic, genotoxic, reproductive,…”
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Characterization of urinary metabolites from [1,2,methoxy-13C]-2-methoxyethanol in mice using 13C nuclear magnetic resonance spectroscopy by SUMNER, S. C. J, STEDMAN, D. B, CLARKE, D. O, WELSCH, F, FENNELL, T. R

“…2-Methoxyethanol (2-ME) is an industrial solvent that induces developmental and testicular toxicity in laboratory animals. Oxidation of 2-ME to 2-methoxyacetic…”
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Metabolism and Disposition of Bisphenol A in Female Rats by Snyder, Rodney W., Maness, Susan C., Gaido, Kevin W., Welsch, Frank, Sumner, Susan C.J., Fennell, Timothy R.

“…Bisphenol A (BPA), which is used in the manufacture of polycarbonates, elicits weak estrogenic activity in in vitro and in vivo test systems. The objectives of…”
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Conformational behavior of the linear hexapeptide senktide: A receptor specific tachykinin analog by Sumner, Susan C.J., Ferretti, James A.

“…A receptor selective linear hexapeptide tachykinin analog, senktide, is shown to be highly ordered in solution. The conformational restriction is attributed to…”
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Conformational analysis of receptor selective tachykinin analogs: senktide and septide by Sumner, S C, Jiang, S P, Jernigan, R L, Ferretti, J A

“…The conformational behavior in solution of two receptor selective tachykinin agonists, senktide (succinyl-D-F-MeF-G-L-M-NH2) and septide (pQ-F-F-P-L-M-NH2) is…”
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