Search Results - "Sumner, Neil F."

New Non-Peptide Endothelin-A Receptor Antagonists:  Synthesis, Biological Properties, and Structure−Activity Relationships of 5-(Dimethylamino)-N-pyridyl-, -N-pyrimidinyl-, -N-pyridazinyl-, and -N-pyrazinyl-1-naphthalenesulfonamides by Bradbury, Robert H, Bath, Colin, Butlin, Roger J, Dennis, Michael, Heys, Christine, Hunt, Sarah J, James, Roger, Mortlock, Andrew A, Sumner, Neil F, Tang, Eric K, Telford, Berwick, Whiting, Elaine, Wilson, Campbell

“…Use of automated synthesis led to the discovery of several 6-membered nitrogen heterocycles as replacements for the N-isoxazolyl substituent present in the…”
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N-methyl-2-[4-(2-methylpropyl)phenyl]-3-(3-methoxy-5-methylpyrazin-2-ylsulfamoyl)benzamide ; One of a class of novel benzenesulphonamides which are orally-active, ETA-Selective endothelin antagonists by MORTLOCK, A. A, BATH, C, WRIGHT, N. D, BUTLIN, R. J, HEYS, C, HUNT, S. J, REID, A. C, SUMNER, N. F, TANG, E. K, WHITING, E, WILSON, C

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N-Methyl-2-[4-(2-methylpropyl)phenyl]-3-(3-methoxy-5-methylpyrazin-2-ylsulfamoyl)benzamide; one of a class of novel benzenesulphonamides which are orally-active, ET A-selective endothelin antagonists by Mortlock, Andrew A., Bath, Colin, Butlin, Roger J., Heys, Christine, Hunt, Sarah J., Reid, Alan C., Sumner, Neil F., Tang, Eric K., Whiting, Elaine, Wilson, Campbell, Wright, Nicola D.

“…A series of novel sulphonamides have been discovered which show high affinity and selectivity for the endothelin ET A receptor…”
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