Search Results - "Sumner, Dale R"

The relative contribution of bone microarchitecture and matrix composition to implant fixation strength in rats by Anderson, Kyle D., Ko, Frank C., Fullam, Spencer, Virdi, Amarjit S., Wimmer, Markus A., Sumner, Dale R., Ross, Ryan D.

“…Bone microarchitectural parameters significantly contribute to implant fixation strength but the role of bone matrix composition is not well understood. To…”
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Sclerostin antibody prevents particle-induced implant loosening by stimulating bone formation and inhibiting bone resorption in a rat model by Liu, Shuo, Virdi, Amarjit S., Sena, Kotaro, Sumner, Dale R.

“…Objective To assess the ability of sclerostin antibody therapy to blunt the negative effects of polyethylene particles on implant fixation and peri‐implant…”
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Optimizing a micro‐computed tomography‐based surrogate measurement of bone‐implant contact by Meagher, Matthew J., Parwani, Rachna N., Virdi, Amarjit S., Sumner, Dale R.

“…ABSTRACT Histology and backscatter scanning electron microscopy (bSEM) are the current gold standard methods for quantifying bone‐implant contact (BIC), but…”
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Sclerostin Antibody Increases Bone Volume and Enhances Implant Fixation in a Rat Model by Virdi, Amarjit S, Liu, Min, Sena, Kotaro, Maletich, James, McNulty, Margaret, Ke, Hua Zhu, Sumner, Dale R

“…BACKGROUND:Previous studies have demonstrated that sclerostin blockade is anabolic for bone. This study examined whether systemic administration of sclerostin…”
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Combined Use of Low-Intensity Pulsed Ultrasound and rhBMP-2 to Enhance Bone Formation in a Rat Model of Critical Size Defect by Angle, Siddhesh R, Sena, Kotaro, Sumner, Dale R, Virkus, Walter W, Virdi, Amarjit S

“…BACKGROUND:Bone repair is regulated by biological factors and the local mechanical environment. We hypothesize that the combined use of low-intensity pulsed…”
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Normalization of joint moments during gait: a comparison of two techniques by Moisio, Kirsten C, Sumner, Dale R, Shott, Susan, Hurwitz, Debra E

“…Joint moments are commonly used to characterize gait. Factors like height and weight influence these moments. This study determined which of two commonly used…”
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Implant placement increases bone remodeling transiently in a rat model by Irish, John, Virdi, Amarjit S., Sena, Kotaro, McNulty, Margaret A., Sumner, Dale R.

“…To examine bone remodeling following implant placement, 88 female Sprague–Dawley rats underwent either sham ovariectomy (sham‐ovx) or ovariectomy (ovx) at 4.5…”
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Relationship between pain and medial knee joint loading in mild radiographic knee osteoarthritis by Thorp, Laura E., Sumner, Dale R., Wimmer, Markus A., Block, Joel A.

“…Objective The relationship between knee pain and radiographic evidence of knee osteoarthritis (OA) is notoriously imperfect. In particular, conditions that…”
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Early gene response to low-intensity pulsed ultrasound in rat osteoblastic cells by Sena, Kotaro, Leven, Robert M, Mazhar, Khurram, Sumner, Dale R, Virdi, Amarjit S

“…The aim of the current research was to quantify the changes in gene expression in rat bone marrow derived stromal cells (BMSC) to low intensity pulsed…”
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Low-intensity pulsed ultrasound (LIPUS) and cell-to-cell communication in bone marrow stromal cells by Sena, Kotaro, Angle, Siddhesh R., Kanaji, Arihiko, Aher, Chetan, Karwo, David G., Sumner, Dale R., Virdi, Amarjit S.

“…► LIPUS-stimulated intercellular calcein dye transfer in bone marrow stromal cells. ► 18β inhibits LIPUS-stimulated intercellular calcein dye transfer. ► 18β…”
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Osteoporosis Treatments Affect Bone Matrix Maturation in a Rat Model of Induced Cortical Remodeling by Ross, Ryan D, Anderson, Kyle, Davison, Reid, El‐Masri, Bilal M, Andreasen, Christina M, Andersen, Thomas L, Sumner, Dale R

“…ABSTRACT To test how osteoporosis drugs affect bone matrix maturation during cortical bone remodeling, 72 pregnant rats were switched from a 0.4% to a 0.01%…”
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Effect of recombinant human transforming growth factor-β2 dose on bone formation in rat femur titanium implant model by Sena, Kotaro, Sumner, Dale R., Virdi, Amarjit S.

“…Previously, we reported that application of 10 μg recombinant human TGF‐β2 (rhTGF‐β2) enhanced peri‐implant bone formation and bone‐implant contact in a rat…”
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Overexpression of DMP1 accelerates mineralization and alters cortical bone biomechanical properties in vivo by Bhatia, Ankush, Albazzaz, Michael, Espinoza Orías, Alejandro A., Inoue, Nozomu, Miller, Lisa M., Acerbo, Alvin, George, Anne, Sumner, Dale R.

“…Dentin matrix protein-1 (DMP1) is a key regulator of biomineralization. Here, we examine changes in structural, geometric, and material properties of cortical…”
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Dynamic knee loads during gait predict proximal tibial bone distribution by Hurwitz, Debra E, Sumner, Dale R, Andriacchi, Thomas P, Sugar, David A

“…This study tested the validity of the prediction of dynamic knee loads based on gait measurements. The relationship between the predicted loads at the knee and…”
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Peri-implant bone formation and implant integration strength of peptide-modified p(AAM-co-EG/AAC) interpenetrating polymer network-coated titanium implants by Barber, Thomas A., Ho, James E., De Ranieri, Aladino, Virdi, Amarjit S., Sumner, Dale R., Healy, Kevin E.

“…Interpenetrating polymer networks (IPNs) of poly (acrylamide‐co‐ethylene glycol/acrylic acid) functionalized with an ‐Arg‐Gly‐Asp‐ (RGD) containing 15 amino…”
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Sensitivity of periprosthetic stress-shielding to load and the bone density–modulus relationship in subject-specific finite element models by Weinans, Harrie, R. Sumner, Dale, Igloria, Ruben, Natarajan, Raghu N

“…Subject-specific finite element (FE) computer models of the proximal femur in hip replacement could potentially predict stress-shielding and subsequent bone…”
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Local application of rhTGF-β2 enhances peri-implant bone volume and bone-implant contact in a rat model by De Ranieri, Aladino, Virdi, Amarjit S., Kuroda, Shinji, Shott, Susan, Leven, Robert M., Hallab, Nadim J., Sumner, Dale R.

“…Orthopedic and dental implant fixation depends upon bone regeneration. Growth factors such as transforming growth factor-beta (TGF-β) have been shown to…”
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Sclerostin Antibody Treatment Improves Implant Fixation in a Model of Severe Osteoporosis by Virdi, Amarjit S, Irish, John, Sena, Kotaro, Liu, Min, Ke, Hua Zhu, McNulty, Margaret A, Sumner, Dale R

“…BACKGROUND:The mechanical fixation of orthopaedic and dental implants is compromised by diminished bone volume, such as with osteoporosis. Systemic…”
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Patterns and localization of gene expression during intramembranous bone regeneration in the rat femoral marrow ablation model by Kuroda, Shinji, Virdi, Amarjit S, Dai, Yang, Shott, Susan, Sumner, Dale R

“…Tissue formation and repair are dependent upon cascades of biological events, but the signals involved and the possible gene coexpression patterns during…”
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Modulation of VEGF Expression in Rat Bone Marrow Stromal Cells by GDF-5 by Sena, Kotaro, Sumner, Dale R., Virdi, Amarjit S.

“…Angiogenesis is essential for bone formation and several bone morphogenetic proteins (BMPs) have been shown to induce angiogenesis through osteoblast-derived…”
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