Search Results - "Summy, Justin M."

Development and characterization of gemcitabine-resistant pancreatic tumor cells by Shah, Ami N, Summy, Justin M, Zhang, Jing, Park, Serk In, Parikh, Nila U, Gallick, Gary E

“…Pancreatic cancer is an exceptionally lethal disease with an annual mortality nearly equivalent to its annual incidence. This dismal rate of survival is due to…”
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Treatment for advanced tumors: SRC reclaims center stage by Summy, Justin M, Gallick, Gary E

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Inhibition of Src Expression and Activity Inhibits Tumor Progression and Metastasis of Human Pancreatic Adenocarcinoma Cells in an Orthotopic Nude Mouse Model by Trevino, Jose G., Summy, Justin M., Lesslie, Donald P., Parikh, Nila U., Hong, David S., Lee, Francis Y., Donato, Nicholas J., Abbruzzese, James L., Baker, Cheryl H., Gallick, Gary E.

“…The nonreceptor protein tyrosine kinase Src is overexpressed in 70% of pancreatic adenocarcinomas. Here, we describe the effect of molecular and…”
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Src activation regulates anoikis in human colon tumor cell lines by WINDHAM, T. Christopher, PARIKH, Nila U, SIWAK, Doris R, SUMMY, Justin M, MCCONKEY, David J, KRAKER, Alan J, GALLICK, Gary E

“…Src is a non-receptor protein tyrosine kinase, the expression and activity of which is increased in >80% of human colon cancers with respect to normal colonic…”
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Expression and activity of src regulate interleukin-8 expression in pancreatic adenocarcinoma cells : Implications for angiogenesis by TREVINO, Jose G, SUMMY, Justin M, GRAY, Michael J, NILSSON, Monique B, LESSLIE, Donald P, BAKER, Cheryl H, GALLICK, Gary E

“…Interleukin-8 (IL-8) is an angiogenic factor that promotes growth of pancreatic tumors. The purpose of this study was to determine if c-Src, a protein tyrosine…”
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AFAP-110 is overexpressed in prostate cancer and contributes to tumorigenic growth by regulating focal contacts by Zhang, Jing, Park, Serk In, Artime, Marlene C, Summy, Justin M, Shah, Ami N, Bomser, Joshua A, Dorfleutner, Andrea, Flynn, Daniel C, Gallick, Gary E

“…The actin filament-associated protein AFAP-110 is an actin cross-linking protein first identified as a substrate of the viral oncogene v-Src. AFAP-110…”
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AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes by Summy, Justin M, Trevino, Jose G, Lesslie, Donald P, Baker, Cheryl H, Shakespeare, William C, Wang, Yihan, Sundaramoorthi, Raji, Metcalf, 3rd, Chester A, Keats, Jeffrey A, Sawyer, Tomi K, Gallick, Gary E

“…c-Src is frequently activated in human malignancies, including colon, breast, and pancreatic carcinomas. Several recent studies have shown that activation of…”
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Src family kinases in tumor progression and metastasis by Summy, Justin M, Gallick, Gary E

“…The Src family of non-receptor protein tyrosine kinases plays critical roles in a variety of cellular signal transduction pathways, regulating such diverse…”
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c-Src regulates constitutive and EGF-mediated VEGF expression in pancreatic tumor cells through activation of phosphatidyl inositol-3 kinase and p38 MAPK by Summy, Justin M, Trevino, Jose G, Baker, Cheryl H, Gallick, Gary E

“…Multiple signaling proteins may be aberrantly activated and/or overexpressed in pancreatic tumors, including the nonreceptor protein tyrosine kinase Src. The…”
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Loss of tyrosine phosphatase-dependent inhibition promotes activation of tyrosine kinase c-Src in detached pancreatic cells by Connelly, Sarah F., Isley, Beth A., Baker, Cheryl H., Gallick, Gary E., Summy, Justin M.

“…Despite an intense focus on novel therapeutic strategies, pancreatic adenocarcinoma remains one of the deadliest human malignancies. The frequent and rapid…”
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Targeting the yin and the yang: combined inhibition of the tyrosine kinase c-Src and the tyrosine phosphatase SHP-2 disrupts pancreatic cancer signaling and biology in vitro and tumor formation in vivo by Gomes, Evan G, Connelly, Sarah F, Summy, Justin M

“…Although c-Src (Src) has emerged as a potential pancreatic cancer target in preclinical studies, Src inhibitors have not demonstrated a significant therapeutic…”
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PKC Phosphorylation Increases the Ability of AFAP-110 to Cross-link Actin Filaments by Qian, Yong, Baisden, Joseph M., Cherezova, Lidia, Summy, Justin M., Guappone-Koay, Anne, Shi, Xianglin, Mast, Tom, Pustula, Jennifer, Zot, Henry G., Mazloum, Nayef, Lee, Marietta Y., Flynn, Daniel C.

“…The actin filament-associated protein and Src-binding partner, AFAP-110, is an adaptor protein that links signaling molecules to actin filaments. AFAP-110…”
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SRC inhibitors as potential therapeutic agents for human cancers by Trevino, Jose G, Summy, Justin M, Gallick, Gary E

“…Selective inhibitors of the Src family of protein tyrosine kinases have been developed as therapeutic agents for human tumors, some of which are now in various…”
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Src activation of Stat3 is an independent requirement from NF-κB activation for constitutive IL-8 expression in human pancreatic adenocarcinoma cells by TREVINO, Jose G, GRAY, Michael J, MCCONKEY, David J, GALLICK, Gary E, NAWROCKI, Steffan T, SUMMY, Justin M, LESSLIE, Donald P, EVANS, Douglas B, SAWYER, Tomi K, SHAKESPEARE, William C, WATOWICH, Stephanie S, CHIAO, Paul J

“…Human pancreatic tumors often overexpress the angiogenesis-promoting factor Interleukin 8 (IL-8), in part due to overexpression of NF- Kappa B, a frequent…”
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Inhibition of PDGFR phosphorylation and Src and Akt activity by GN963 leads to therapy of human pancreatic cancer growing orthotopically in nude mice by BAKER, Cheryl H, TREVINO, Jose G, SUMMY, Justin M, FAHAO ZHANG, CARON, Alexis, NESBIT, Mark, GALLICK, Gary E, FIDLER, Isaiah J

“…GN963 is a tyrosine kinase inhibitor with activity against platelet-derived growth factor receptor (PDGFR) and Src kinases. We determined whether oral…”
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The SH4-Unique-SH3-SH2 domains dictate specificity in signaling that differentiate c-Yes from c-Src by Summy, Justin M, Qian, Yong, Jiang, Bing-Hua, Guappone-Koay, Anne, Gatesman, Amanda, Shi, Xianglin, Flynn, Daniel C

“…c-Src and c-Yes are highly homologous members of the Src family of non-receptor tyrosine kinases. The overall sequence similarity between c-Src and c-Yes…”
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PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments by Qian, Yong, Baisden, Joseph M, Cherezova, Lidia, Summy, Justin M, Guappone-Koay, Anne, Shi, Xianglin, Mast, Tom, Pustula, Jennifer, Zot, Henry G, Mazloum, Nayef, Lee, Marietta Y, Flynn, Daniel C

“…The actin filament-associated protein and Src-binding partner, AFAP-110, is an adaptor protein that links signaling molecules to actin filaments. AFAP-110…”
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Specificity in signaling by c-Yes by Summy, Justin M, Sudol, Marius, Eck, Michael J, Monteiro, Alvaro N, Gatesman, Amanda, Flynn, Daniel C

“…c-Yes and c-Src are the two most closely related members of the Src family of nonreceptor tyrosine kinases. Although there is much evidence to support…”
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The SH3 and SH2 domains are capable of directing specificity in protein interactions between the non-receptor tyrosine kinases cSrc and cYes by SUMMY, J. M, GUAPPONE, A. C, SUDOL, M, FLYNN, D. C

“…The c-src and c-yes proto-oncogenes encode 60 000 and 62 000 Dalton non-receptor tyrosine kinases of the Src family, pp60c-src and pp62c-yes, respectively…”
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Abstract 2859: Dual targeting of protein tyrosine kinase c-Src and protein tyrosine phosphatase SHP-2 is a novel therapeutic strategy that induces potent inhibition of pancreatic cancer cell viability in vitro and tumor progression in vivo by Gomes, Evan, Connelly, Sarah F., Summy, Justin M.

“…Abstract Pancreatic adenocarcinoma is a deadly human malignancy, with over 95% of patients succumbing within five years. The majority of pancreatic cancer…”
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