Search Results - "Summo, Luciana"

Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humans by van Eijk, Lucas T., John, Aaron S.E., Schwoebel, Frank, Summo, Luciana, Vauléon, Stéphanie, Zöllner, Stefan, Laarakkers, Coby M., Kox, Matthijs, van der Hoeven, Johannes G., Swinkels, Dorine W., Riecke, Kai, Pickkers, Peter

“…Increased hepcidin production is key to the development of anemia of inflammation. We investigated whether lexaptepid, an antihepcidin l-oligoribonucleotide,…”
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Identification of peripheral vascular function measures and circulating biomarkers of mitochondrial function in patients with mitochondrial disease by Kraaij, Sebastiaan J. W., Pereira, Diana R., Smal, Bastiaan, Summo, Luciana, Konkel, Anne, Lossie, Janine, Busjahn, Andreas, Grammatopoulos, Tom N., Klaassen, Erica, Fischer, Robert, Schunck, Wolf‐Hagen, Gal, Pim, Moerland, Matthijs

“…The development of pharmacological therapies for mitochondrial diseases is hampered by the lack of tissue‐level and circulating biomarkers reflecting effects…”
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Assessment of OMT-28, a synthetic analog of omega-3 epoxyeicosanoids, in patients with persistent atrial fibrillation: Rationale and design of the PROMISE-AF phase II study by Berlin, Sarah, Goette, Andreas, Summo, Luciana, Lossie, Janine, Gebauer, Alexander, Al-Saady, Naab, Calo, Leonardo, Naccarelli, Gerald, Schunck, Wolf-Hagen, Fischer, Robert, Camm, A.John, Dobrev, Dobromir

“…We designed a placebo controlled, double-blind, randomized, dose-finding phase II study on OMT-28 in the maintenance of sinus rhythm after electrical…”
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FP660PHARMACOKINETICS AND PHARMACODYNAMICS OF LEXAPTEPID, A NOVEL ANTI-HEPCIDIN MOLECULE, IN ESA-RESISTANT HAEMODIALYSIS PATIENTS by Macdougall, Iain C, Rumjon, Adam, Cinco, Jake, Goldstein, Leela, Summo, Luciana, Vauleon, Stéphanie, Riecke, Kai

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Abstract 3847: The anti-hepcidin Spiegelmer® Lexaptepid Pegol (NOX-H94) as treatment of anemia of chronic disease in patients with multiple myeloma, low grade lymphoma, and CLL: A phase II pilot study by Georgiev, Pencho, Lazaroiu, Mihaela, Ocroteala, Luminita, Grudeva-Popova, Janet, Gheorghita, Emanuil, Vasilica, Mariana, Popescu, Sanda M, Cucuianu, Andrei, Summo, Luciana, Schwoebel, Frank, Riecke, Kai, Ludwig, Heinz

“…Abstract Lexaptepid pegol (LP) is a PEGylated L-stereoisomer RNA aptamer that binds and neutralizes hepcidin. Hepcidin, a 25 amino acid peptide induced by…”
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Single and Repeated Dose First-in-Human Study with the Anti-Hepcidin Spiegelmer Nox-H94 by Riecke, Kai, Zöllner, Stefan, Boyce, Malcolm, Vauléon, Stephanie, Swinkels, Dorine W., Dümmler, Thomas, Summo, Luciana, Laarakkers, Coby, Schwoebel, Frank, Fliegert, Frank

“…Abstract 2342 NOX-H94, the first-in-class hepcidin inhibitor in development for treatment of anemia of chronic disease (ACD), is a PEGylated anti-hepcidin…”
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Randomized Double Blind Placebo Controlled PK/PD Study On the Effects of a Single Intravenous Dose of the Anti-Hepcidin Spiegelmer Nox-H94 On Serum Iron During Experimental Human Endotoxemia by van Eijk, Lucas, Swinkels, Dorine W., Aaron, John, Schwoebel, Frank, Fliegert, Frank, Summo, Luciana, Stéphanie, Vauleon, Laarakkers, Coby, Riecke, Kai, Pikkers, Peter

“…Abstract 3452 Anemia of chronic disease (ACD) is generally attributed to increased hepcidin production. The first-in-class hepcidin antagonist NOX-H94, a…”
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Lipophilicity Plays a Major Role in Modulating the Inhibition of Monoamine Oxidase B by 7-Substituted Coumarins by Carotti, Angelo, Altomare, Cosimo, Catto, Marco, Gnerre, Carmela, Summo, Luciana, De Marco, Agostino, Rose, Sarah, Jenner, Peter, Testa, Bernard

“…A series of coumarin derivatives (1–22), bearing at the 7‐position ether, ketone, ester, carbamate, or amide functions of varying size and lipophilicity, were…”
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Inhibition of Monoamine Oxidase-B by Condensed Pyridazines and Pyrimidines:  Effects of Lipophilicity and Structure−Activity Relationships by Altomare, Cosimo, Cellamare, Saverio, Summo, Luciana, Catto, Marco, Carotti, Angelo, Thull, Ulrike, Carrupt, Pierre-Alain, Testa, Bernard, Stoeckli-Evans, Helen

“…A number of condensed pyridazines and pyrimidines were synthesized and tested for their monoamine oxidase-A (MAO-A) and MAO-B inhibitory activity. Their…”
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Investigation of platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids by DE CANDIA, Modesto, SUMMO, Luciana, CARRIERI, Antonio, ALTOMARE, Cosimo, NARDECCHIA, Adele, CELLAMARE, Saverio, CAROTTI, Angelo

“…A series of anilides and phenyl esters of piperidine-3-carboxylic acid (nipecotic acid) were synthesized and tested for the ability to inhibit aggregation of…”
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