Search Results - "Summers, M F"

Targeting of Murine Leukemia Virus Gag to the Plasma Membrane Is Mediated by PI(4,5)P2/PS and a Polybasic Region in the Matrix by HAMARD-PERON, E, JUILLARD, F, SAAD, J. S, ROY, C, ROINGEARD, P, SUMMERS, M. F, DARLIX, J.-L, PICART, C, MURIAUX, D

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Structure of the HIV-1 Nucleocapsid Protein Bound to the SL3 ψ-RNA Recognition Element by de Guzman, Roberto N., Wu, Zheng Rong, Stalling, Chelsea C., Pappalardo, Lucia, Borer, Philip N., Summers, Michael F.

“…The three-dimensional structure of the human immunodeficiency virus-type 1 (HIV-1) nucleocapsid protein (NC) bound to the SL3 stem-loop recognition element of…”
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Structure of the Amino-Terminal Core Domain of the HIV-1 Capsid Protein by Gitti, Rossitza K., Lee, Brian M., Walker, Jill, Summers, Michael F., Yoo, Sanghee, Sundquist, Wesley I.

“…The three-dimensional structure of the amino-terminal core domain (residues 1 through 151) of the human immunodeficiency virus-type 1 (HIV-1) capsid protein…”
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Adaptive management of river flows in Europe: A transferable framework for implementation by Summers, M.F., Holman, I.P., Grabowski, R.C.

“…•We propose a new framework for implementing adaptive management of river flows.•The framework ensures compliance with Water Framework Directive…”
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A Mechanism for Plus-Strand Transfer Enhancement by the HIV-1 Nucleocapsid Protein during Reverse Transcription by Johnson, Philip E, Turner, Ryan B, Wu, Zheng Rong, Hairston, Lea, Guo, Jianhui, Levin, Judith G, Summers, Michael F

“…The HIV-1 nucleocapsid protein (NC) functions as a nucleic acid chaperone during the plus-strand transfer step in reverse transcription by facilitating…”
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Entropic Switch Regulates Myristate Exposure in the HIV-1 Matrix Protein by Tang, Chun, Loeliger, Erin, Luncsford, Paz, Kinde, Isaac, Beckett, Dorothy, Summers, Michael F.

“…The myristoylated matrix protein (myr-MA) of HIV functions as a regulator of intracellular localization, targeting the Gag precursor polyprotein to lipid rafts…”
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Structural biology of HIV by Turner, B G, Summers, M F

“…The human immunodeficiency virus (HIV) genome encodes a total of three structural proteins, two envelope proteins, three enzymes, and six accessory proteins…”
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Nucleocapsid zinc fingers detected in retroviruses: EXAFS studies of intact viruses and the solution‐state structure of the nucleocapsid protein from HIV‐1 by Summers, Michael F., Henderson, Louis E., Chance, Mark R., South, Terri L., Blake, Paul R., Perez‐Alvarado, Gabriela, Bess, Julian W., Sowder, Raymond C., Arthur, Larry O., Sagi, Irit, Hare, Dennis R.

“…All retroviral nucleocapsid (NC) proteins contain one or two copies of an invariant 3Cys‐1His array (CCHC = C‐X2‐C‐X4‐H‐X4‐C; C = Cys, H = His, X = variable…”
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High-resolution structure of an HIV zinc fingerlike domain via a new NMR-based distance geometry approach by Summers, Michael F, South, Terri L, Kim, Bo, Hare, Dennis R

“…A new method is described for determining molecular structures from NMR data. The approach utilizes 2D NOESY back-calculations to generate simulated spectra…”
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Inhibition of HIV-1 infectivity by zinc-ejecting aromatic C -nitroso compounds by Rice, William G, Schaeffer, Catherine A, Harten, Brad, Villinger, Francois, South, Terri L, Summers, Michael F, Henderson, Louis E, Bess, Julian W, Arthur, Larry O, McDougal, J. Steven, Orloff, Sherry L, Mendeleyev, Jerome, Kun, Ernest

“…Retroviral nucleocapsid and gag-precursor proteins from all known strains of retroviruses contain one or two copies of an invariant sequence,…”
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Structure of the N-terminal 283-residue fragment of the immature HIV-1 Gag polyprotein by Summers, Michael F, Tang, Chun, Ndassa, Yasmine

“…The capsid protein (CA) of the mature human immunodeficiency virus (HIV) contains an N-terminal beta-hairpin that is essential for formation of the capsid core…”
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Antiviral Inhibition of the HIV-1 Capsid Protein by Tang, Chun, Loeliger, Erin, Kinde, Isaac, Kyere, Samson, Mayo, Keith, Barklis, Eric, Sun, Yongnian, Huang, Mingjun, Summers, Michael F

“…During the assembly stage of the human immunodeficiency virus (HIV) replication cycle, several thousand copies of the viral Gag polyprotein associate at the…”
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NMR Structure of the 101-nucleotide Core Encapsidation Signal of the Moloney Murine Leukemia Virus by D'Souza, Victoria, Dey, Anwesha, Habib, Dina, Summers, Michael F.

“…The full length, positive-strand genome of the Moloney Murine Leukemia Virus contains a “core encapsidation signal” that is essential for efficient genome…”
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Evaluation of Selected Chemotypes in Coupled Cellular and Molecular Target-Based Screens Identifies Novel HIV-1 Zinc Finger Inhibitors by Rice, William G, Turpin, Jim A, Schaeffer, Catherine A, Graham, Lisa, Clanton, David, Buckheit, Robert W, Zaharevitz, Daniel, Summers, Michael F, Wallqvist, Anders, Covell, David G

“…Conservation of the Cys-Xaa2-Cys-Xaa4-His-Xaa4-Cys retroviral zinc finger sequences and their absolute requirement in both the early and late phases of…”
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NMR structure of the HIV-1 nucleocapsid protein bound to stem-loop SL2 of the psi-RNA packaging signal. Implications for genome recognition by Amarasinghe, G K, De Guzman, R N, Turner, R B, Chancellor, K J, Wu, Z R, Summers, M F

“…The RNA genome of the human immunodeficiency virus type-1 (HIV-1) contains a approximately 120 nucleotide Psi-packaging signal that is recognized by the…”
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Comparison of the backbone dynamics of the apo- and holo-carboxy-terminal domain of the biotin carboxyl carrier subunit of Escherichia coli acetyl-CoA carboxylase by YAO, XIANG, SODEN, CYLBURN, SUMMERS, MICHAEL F., BECKETT, DOROTHY

“…The biotin carboxyl carrier protein (BCCP) is a subunit of acetyl-CoA carboxylase, a biotin-dependent enzyme that catalyzes the first committed step of fatty…”
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Determinants of protein hyperthermostability: purification and amino acid sequence of rubredoxin from the hyperthermophilic archaebacterium Pyrococcus furiosus and secondary structure of the zinc adduct by NMR by Blake, Paul R, Park, Jae Bum, Bryant, Frank O, Aono, Shigetoshi, Magnuson, Jon K, Eccleston, Eric, Howard, James B, Summers, Michael F, Adams, Michael W. W

“…The purification, amino acid sequence, and two-dimensional 1H NMR results are reported for the rubredoxin (Rd) from the hyperthermophilic archaebacterium…”
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Comparison of the NMR and X‐ray structures of the HIV‐1 matrix protein: Evidence for conformational changes during viral assembly by Massiah, Michael A., Worthylake, David, Christensen, Allyson M., Sundquist, Wesley I., Hill, Christopher P., Summers, Michael F.

“…The three‐dimensional solution‐ and solid‐state structures of the human immunodeficiency virus type‐1 (HIV‐1) matrix protein have been determined recently in…”
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Zinc Ejection as a New Rationale for the Use of Cystamine and Related Disulfide-Containing Antiviral Agents in the Treatment of AIDS by McDonnell, Nazli B, De Guzman, Roberto N, Rice, William G, Turpin, Jim A, Summers, Michael F

“…The highly conserved and mutationally intolerant retroviral zinc finger motif of the HIV-1 nucleocapsid protein (NC) is an attractive target for drug therapy…”
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Zinc finger motif for single-stranded nucleic acids? Investigations by nuclear magnetic resonance by Summers, M F

“…Nuclear magnetic resonance (NMR) methods have been used to address issues regarding the relevance and feasibility of zinc binding to "zinc finger-like"…”
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