Search Results - "Summers, Kelly"

A Structural Chemistry Perspective on the Antimalarial Properties of Thiosemicarbazone Metal Complexes by Summers, Kelly L

“…Malaria is a potentially life-threatening disease, affecting approx. 214 million people worldwide. Malaria is caused by a protozoan, Plasmodium falciparum,…”
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'I'm being pulled in too many different directions': academic identity tensions at regional public universities in challenging economic times by Dugas, Daryl, Stich, Amy E., Harris, Lindsay N., Summers, Kelly H.

“…Faculty (N = 205) at regional public universities (RPUs) in the United States were surveyed for self-reports of their primary academic identity (teacher,…”
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Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial by Joy, Tisha R, McKenzie, Charles A, Tirona, Rommel G, Summers, Kelly, Seney, Shannon, Chakrabarti, Subrata, Malhotra, Neel, Beaton, Melanie D

“…AIM To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of nonalcoholic steatohepatitis(NASH).METHODS Twelve patients…”
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A Multimodal Spectroscopic Imaging Method To Characterize the Metal and Macromolecular Content of Proteinaceous Aggregates (“Amyloid Plaques”) by Summers, Kelly L, Fimognari, Nicholas, Hollings, Ashley, Kiernan, Mitchell, Lam, Virginie, Tidy, Rebecca J, Paterson, David, Tobin, Mark J, Takechi, Ryu, George, Graham N, Pickering, Ingrid J, Mamo, John C, Harris, Hugh H, Hackett, Mark J

“…Alzheimer’s disease (AD) is a major international health and economic concern. A key pathological feature of AD is so-called “amyloid-β-plaques”, or…”
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Deconstructing bullying roles: A longitudinal latent profile analysis of bullying participant behaviors for students in grades 4 through 12 by Demaray, Michelle K., Malecki, Christine K., Ryoo, Ji Hoon, Summers, Kelly H.

“…Bullying behavior is understood as a complex social phenomenon that includes many, and sometimes overlapping, bullying participant behaviors. The current study…”
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Chronic stress physically spares but functionally impairs innate-like invariant T cells by Rudak, Patrick T., Choi, Joshua, Parkins, Katie M., Summers, Kelly L., Jackson, Dwayne N., Foster, Paula J., Skaro, Anton I., Leslie, Ken, McAlister, Vivian C., Kuchroo, Vijay K., Inoue, Wataru, Lantz, Olivier, Haeryfar, S.M. Mansour

“…The deleterious effects of psychological stress on mainstream T lymphocytes are well documented. However, how stress impacts innate-like T cells is unclear. We…”
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Bimodal Nickel-Binding Site on Escherichia coli [NiFe]-Hydrogenase Metallochaperone HypA by Lacasse, Michael J, Summers, Kelly L, Khorasani-Motlagh, Mozhgan, George, Graham N, Zamble, Deborah B

“…[NiFe]-hydrogenase enzymes catalyze the reversible oxidation of hydrogen at a bimetallic cluster and are used by bacteria and archaea for anaerobic growth and…”
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Alzheimer’s Drug PBT2 Interacts with the Amyloid β 1–42 Peptide Differently than Other 8‑Hydroxyquinoline Chelating Drugs by Summers, Kelly L., Roseman, Graham, Schilling, Kevin M., Dolgova, Natalia V., Pushie, M. Jake, Sokaras, Dimosthenis, Kroll, Thomas, Harris, Hugh H., Millhauser, Glenn L., Pickering, Ingrid J., George, Graham N.

“…Although Alzheimer’s disease (AD) was first described over a century ago, it remains the leading cause of age-related dementia. Innumerable changes have been…”
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Novel regulatory Th17 cells and regulatory B cells in modulating autoimmune diseases by Singh, Bhagirath, Summers, Kelly L., Kerfoot, Steven M.

“…•Regulatory B and T lymphocytes contribute to the prevention and modulation of autoimmune diseases.•IL-17 producing regulatory Th17 cells, termed as Treg17…”
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Copper(II) Binding to PBT2 Differs from That of Other 8‑Hydroxyquinoline Chelators: Implications for the Treatment of Neurodegenerative Protein Misfolding Diseases by Summers, Kelly L, Roseman, Graham P, Sopasis, George J, Millhauser, Glenn L, Harris, Hugh H, Pickering, Ingrid J, George, Graham N

“…PBT2 (5,7-dichloro-2-[(dimethylamino)­methyl]-8-hydroxyquinoline) is a small Cu­(II)-binding drug that has been investigated in the treatment of…”
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X‑ray Absorption Spectroscopy Investigations of Copper(II) Coordination in the Human Amyloid β Peptide by Summers, Kelly L, Schilling, Kevin M, Roseman, Graham, Markham, Kate A, Dolgova, Natalia V, Kroll, Thomas, Sokaras, Dimosthenis, Millhauser, Glenn L, Pickering, Ingrid J, George, Graham N

“…Alzheimer’s disease (AD) is the main cause of age-related dementia and currently affects approximately 5.7 million Americans. Major brain changes associated…”
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Structural Characterization of the Solution Chemistry of Zirconium(IV) Desferrioxamine: A Coordination Sphere Completed by Hydroxides by Summers, Kelly L, Sarbisheh, Elaheh Khozeimeh, Zimmerling, Amanda, Cotelesage, Julien J. H, Pickering, Ingrid J, George, Graham N, Price, Eric W

“…Positron emission tomography (PET) using radiolabeled, monoclonal antibodies has become an effective, noninvasive method for tumor detection and is a critical…”
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Atrial fibrillation detected after stroke is related to a low risk of ischemic stroke recurrence by Sposato, Luciano A, Cerasuolo, Joshua O, Cipriano, Lauren E, Fang, Jiming, Fridman, Sebastian, Paquet, Maryse, Saposnik, Gustavo

“…OBJECTIVETo compare the risk of 1-year ischemic stroke recurrence between atrial fibrillation (AF) diagnosed after stroke (AFDAS) and sinus rhythm (SR) and…”
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Radiochemical, Computational, and Spectroscopic Evaluation of High-Denticity Desferrioxamine Derivatives DFO2 and DFO2p toward an Ideal Zirconium-89 Chelate Platform by Khozeimeh Sarbisheh, Elaheh, Summers, Kelly L., Salih, Akam K., Cotelesage, Julien J. H., Zimmerling, Amanda, Pickering, Ingrid J., George, Graham N., Price, Eric W.

“…Desferrioxamine (DFO) has long been considered the gold standard chelator for incorporating [89Zr]­Zr4+ in radiopharmaceuticals for positron emission…”
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Human red blood cell uptake and sequestration of arsenite and selenite: Evidence of seleno-bis(S-glutathionyl) arsinium ion formation in human cells by Kaur, Gurnit, Javed, Warda, Ponomarenko, Olena, Shekh, Kamran, Swanlund, Diane P., Zhou, Janet R., Summers, Kelly L., Casini, Angela, Wenzel, Margot N., Casey, Joseph R., Cordat, Emmanuelle, Pickering, Ingrid J., George, Graham N., Leslie, Elaine M.

“…[Display omitted] Over 200 million people worldwide are exposed to the human carcinogen, arsenic, in contaminated drinking water. In laboratory animals,…”
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Stress-elicited glucocorticoid receptor signaling upregulates TIGIT in innate-like invariant T lymphocytes by Rudak, Patrick T., Gangireddy, Rakshith, Choi, Joshua, Burhan, Amer M., Summers, Kelly L., Jackson, Dwayne N., Inoue, Wataru, Haeryfar, S.M. Mansour

“…•Prolonged or chronic stress induces TIGIT upregulation by invariant T cells.•Stress-induced TIGIT expression is mediated by endogenous glucocorticoids.•TIGIT…”
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Imatinib in active diffuse cutaneous systemic sclerosis: Results of a six‐month, randomized, double‐blind, placebo‐controlled, proof‐of‐concept pilot study at a single center by Pope, Janet, McBain, Donna, Petrlich, Lisa, Watson, Sharon, Vanderhoek, Louise, de Leon, Faye, Seney, Shannon, Summers, Kelly

“…Objective To better understand the feasibility of using imatinib, a tyrosine kinase inhibitor, to treat active diffuse cutaneous systemic sclerosis (dcSSc)…”
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Solution Chemistry of Copper(II) Binding to Substituted 8‑Hydroxyquinolines by Summers, Kelly L, Pushie, M. Jake, Sopasis, George J, James, Ashley K, Dolgova, Natalia V, Sokaras, Dimosthenis, Kroll, Thomas, Harris, Hugh H, Pickering, Ingrid J, George, Graham N

“…8-Hydroxyquinolines (8HQs) are a family of lipophilic metal ion chelators that have been used in a range of analytical and pharmaceutical applications over the…”
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Cysteine accessibility during As3+ metalation of the α- and β-domains of recombinant human MT1a by Irvine, Gordon W., Summers, Kelly L., Stillman, Martin J.

“…[Display omitted] •ESI-mass spectral data provide key information about the As metalation mechanism of MT.•Arsenic binds to the isolated domain fragments to…”
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Studies of selenium and arsenic mutual protection in human HepG2 cells by Kaur, Gurnit, Ponomarenko, Olena, Zhou, Janet R., Swanlund, Diane P., Summers, Kelly L., Dolgova, Natalia V., Antipova, Olga, Pickering, Ingrid J., George, Graham N., Leslie, Elaine M.

“…Hundreds of millions of people worldwide are exposed to unacceptable levels of carcinogenic inorganic arsenic. Animal models have shown that selenium and…”
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