Search Results - "Summers, Daniel W"

Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism by Gerdts, Josiah, Summers, Daniel W., Milbrandt, Jeffrey, DiAntonio, Aaron

“…Wallerian axon degeneration is a form of programmed subcellular death that promotes axon breakdown in disease and injury. Active degeneration requires SARM1…”
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TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes by Essuman, Kow, Summers, Daniel W., Sasaki, Yo, Mao, Xianrong, Yim, Aldrin Kay Yuen, DiAntonio, Aaron, Milbrandt, Jeffrey

“…The Toll/interleukin-1 receptor (TIR) domain is the signature signaling domain of Toll-like receptors (TLRs) and their adaptors, serving as a scaffold for the…”
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Sarm1-mediated axon degeneration requires both SAM and TIR interactions by Gerdts, Josiah, Summers, Daniel W, Sasaki, Yo, DiAntonio, Aaron, Milbrandt, Jeffrey

“…Axon degeneration is an evolutionarily conserved pathway that eliminates damaged or unneeded axons. Manipulation of this poorly understood pathway may allow…”
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Palmitoylation enables MAPK-dependent proteostasis of axon survival factors by Summers, Daniel W., Milbrandt, Jeffrey, DiAntonio, Aaron

“…Axon degeneration is a prominent event in many neurodegenerative disorders. Axon injury stimulates an intrinsic self-destruction program that culminates in…”
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SARM1-specific motifs in the TIR domain enable NAD⁺ loss and regulate injury-induced SARM1 activation by Summers, Daniel W., Gibson, Daniel A., DiAntonio, Aaron, Milbrandt, Jeffrey

“…Axon injury in response to trauma or disease stimulates a self-destruction program that promotes the localized clearance of damaged axon segments. Sterile…”
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Gene therapy targeting SARM1 blocks pathological axon degeneration in mice by Geisler, Stefanie, Huang, Shay X, Strickland, Amy, Doan, Ryan A, Summers, Daniel W, Mao, Xianrong, Park, Jiwoong, DiAntonio, Aaron, Milbrandt, Jeffrey

“…Axonal degeneration (AxD) following nerve injury, chemotherapy, and in several neurological disorders is an active process driven by SARM1, an injury-activated…”
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Microtubules, Membranes, and Movement: New Roles for Stathmin‐2 in Axon Integrity by Thornburg‐Suresh, Emma J. C., Summers, Daniel W.

“…ABSTRACT Neurons establish functional connections responsible for how we perceive and react to the world around us. Communication from a neuron to its target…”
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MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2 by Walker, Lauren J, Summers, Daniel W, Sasaki, Yo, Brace, E J, Milbrandt, Jeffrey, DiAntonio, Aaron

“…Injury-induced (Wallerian) axonal degeneration is regulated via the opposing actions of pro-degenerative factors such as SARM1 and a MAPK signal and…”
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The Type II Hsp40 Sis1 cooperates with Hsp70 and the E3 ligase Ubr1 to promote degradation of terminally misfolded cytosolic protein by Summers, Daniel W, Wolfe, Katie J, Ren, Hong Yu, Cyr, Douglas M

“…Mechanisms for cooperation between the cytosolic Hsp70 system and the ubiquitin proteasome system during protein triage are not clear. Herein, we identify new…”
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Loss of Sarm1 reduces retinal ganglion cell loss in chronic glaucoma by Zeng, Huilan, Mayberry, Jordan E, Wadkins, David, Chen, Nathan, Summers, Daniel W, Kuehn, Markus H

“…Glaucoma is one of the leading causes of irreversible blindness worldwide and vision loss in the disease results from the deterioration of retinal ganglion…”
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The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration by Essuman, Kow, Summers, Daniel W., Sasaki, Yo, Mao, Xianrong, DiAntonio, Aaron, Milbrandt, Jeffrey

“…Axonal degeneration is an early and prominent feature of many neurological disorders. SARM1 is the central executioner of the axonal degeneration pathway that…”
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Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons by Summers, Daniel W, DiAntonio, Aaron, Milbrandt, Jeffrey

“…Mitochondrial dysfunction is the underlying cause of many neurological disorders, including peripheral neuropathies. Mitochondria rely on a proton gradient to…”
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The Type I Hsp40 Ydj1 Utilizes a Farnesyl Moiety and Zinc Finger-like Region to Suppress Prion Toxicity by Summers, Daniel W., Douglas, Peter M., Ren, Hong-Yu, Cyr, Douglas M.

“…Type I Hsp40s are molecular chaperones that protect neurons from degeneration by modulating the aggregation state of amyloid-forming proteins. How Type I…”
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Identification of a consensus motif in substrates bound by a Type I Hsp40 by Kota, Pradeep, Summers, Daniel W, Ren, Hong-Yu, Cyr, Douglas M, Dokholyan, Nikolay V

“…Protein aggregation is a hallmark of a large and diverse number of conformational diseases. Molecular chaperones of the Hsp40 family (Escherichia coli DnaJ…”
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DLK Activation Synergizes with Mitochondrial Dysfunction to Downregulate Axon Survival Factors and Promote SARM1-Dependent Axon Degeneration by Summers, Daniel W., Frey, Erin, Walker, Lauren J., Milbrandt, Jeffrey, DiAntonio, Aaron

“…Axon degeneration is a prominent component of many neurological disorders. Identifying cellular pathways that contribute to axon vulnerability may identify new…”
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The Stathmin-2 membrane-targeting domain is required for axon protection and regulated degradation by DLK signaling by Thornburg-Suresh, Emma J.C., Richardson, Jerianne E., Summers, Daniel W.

“…Axon integrity is essential for functional connectivity in the nervous system. The degeneration of stressed or damaged axons is a common and sometimes…”
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Molecular chaperones antagonize proteotoxicity by differentially modulating protein aggregation pathways by Douglas, Peter M., Summers, Daniel W., Cyr, Douglas M.

“…The self-association of misfolded or damaged proteins into ordered amyloid-like aggregates characterizes numerous neurodegenerative disorders.  Insoluble…”
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Prion propagation by Hsp40 molecular chaperones by Summers, Daniel W., Douglas, Peter M., Cyr, Douglas M.

“…Molecular chaperones regulate essential steps in the propagation of yeast prions. Yeast prions possess domains enriched in glutamines and asparagines that act…”
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Transcription errors induce proteotoxic stress and shorten cellular lifespan by Vermulst, Marc, Denney, Ashley S., Lang, Michael J., Hung, Chao-Wei, Moore, Stephanie, Moseley, M. Arthur, Thompson, J. Will, Madden, Victoria, Gauer, Jacob, Wolfe, Katie J., Summers, Daniel W., Schleit, Jennifer, Sutphin, George L., Haroon, Suraiya, Holczbauer, Agnes, Caine, Joanne, Jorgenson, James, Cyr, Douglas, Kaeberlein, Matt, Strathern, Jeffrey N., Duncan, Mara C., Erie, Dorothy A.

“…Transcription errors occur in all living cells; however, it is unknown how these errors affect cellular health. To answer this question, we monitor yeast cells…”
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Polypeptide transfer from Hsp40 to Hsp70 molecular chaperones by Summers, Daniel W., Douglas, Peter M., Ramos, Carlos H.I., Cyr, Douglas M.

“…Heat shock protein 40 (Hsp40) co-chaperones assist in cellular protein folding and degradation through the binding and delivery of non-native proteins to heat…”
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